MedComm
·
2024
·Vol. 5
·期 11
·e688
·
IF 10.7
Yuejia Chen,Du Guo,Xin Wang,Changbin Zhang,Yatian Chen,Qinghua Luo,Yujiao Chen,Lili Yang,Zhibo Zhang,Tian Hong,Zhengyu Zhang,Haohao Dong,Shenghai Chang,Jianping Hu,Xiaodi Tang
The filamentous temperature-sensitive (Fts) protein FtsEX plays a pivotal role in Escherichia coli ( E. coli ) cell division by facilitating the activation of peptidoglycan hydrolysis through the adaptor EnvC. FtsEX belongs to the type VII ATP-binding cassette (ABC) transporter superfamily, which harnesses ATP energy to induce mechanical force, triggering a cascade of conformational changes that activate the pathway. However, the precise mechanism by which FtsEX initiates mechanotransmission remains elusive. Due to the inherent instability of this type of ABC transporter protein in vitro, the conformation of FtsEX has solely been determined in the stabilized ATP-bound state. To elucidate the dynamics of FtsEX, we characterized FtsEX and EnvC of various functional structures through cryo-electron microscopy (cryo-EM) and homology modeling. We validated the structures by molecular dynamics simulations. By site-directed mutagenesis and phenotype screening, we also identified the functional residues involved in allosteric communication between FtsE and FtsX as well as FtsX and EnvC. Additionally, we discovered a potential role of phospholipids in stabilizing the complex conformation during mechanotransmission. This comprehensive exploration significantly enhances our understanding of the intricate mechanisms governing bacterial cell division and unveils potential molecular targets for developing innovative antimicrobial drugs to combat antibiotic resistance.
研究领域:
微生物学
·
结构生物学
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Yihao Wang,Zaichun Sun,Bingchu Mei
Bismuth chalcohalides demonstrate tunable optical and electronic properties, offering new orientations for the material design and properties exploration. Recently, bismuth sulfide halides (Bi 13 S 18 X 2 , X═Cl, Br, I) have been regarded as a kind of potential infrared (IR) photoelectrical materials, owing to the narrow bandgap, small effective mass, and low toxicity. In this work, (310)-orientated Bi 13 S 18 Br 2 thin films are synthesized on the α-Al 2 O 3 (0001) single crystal via mist chemical vapor deposition at atmospheric pressure. Bi 13 S 18 Br 2 thin films possessed a narrow bandgap of ≈0.85 eV, suitable for harvesting the light from ultraviolet to the near-IR range. The conduction mechanism of Bi 13 S 18 Br 2 is discussed from 2 to 300 K. The Bi 13 S 18 Br 2 -based photodetector exhibited interesting near-IR photodetection performance, which is comparable and even superior to the well-investigated IR photodetectors. The responsivity reached up to 10.0 and 7.3 A W −1 under the illumination of 808 and 1064 nm light, respectively. This study is expected to contribute to the development of “mixed-anion electronics” and advance photodetection techniques.
研究领域:
材料科学
·
光电技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zihan Xiong,Jinrong Huang,Jianwen Chen,Zenghe Liu,Yutian Zhu,Guoxin Sui,Zunfeng Liu
Flexible piezoresistive pressure sensors with wide linear range, high sensitivity, low detection limit and fast response are highly desirable for wearable electronics, electronic skins, and human–machine interactions. Traditionally, achieving an optimal balance among sensitivity, detection limit, and linear range has been challenging, limiting practical applications of the sensors in various fields. Herein, a novel approach leveraging the synergy of hierarchical structures and multiple conduction mechanisms is available to overcome these limitations. The innovative sensor, composing of an interdigital electrode and a sandpaper-like pressure-sensitive layer with both ionic and electronic conduction, demonstrates an exceptional linear response (R 2 > 0.999) over a broad range of up to 1138 kPa. It combines high sensitivity (2.69 kPa −1 ) with a low detection limit (5.67 Pa) and exhibits rapid response/recovery times (13.77 ms and 18.73 ms, respectively), along with excellent long-term stability. These remarkable attributes make the sensor ideal for detecting full-range human physiological signals and supporting remote haptic interactions, showcasing its potential in personal health monitoring and interactive technologies.
研究领域:
材料科学
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电子皮肤技术
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2020
·
IF 7.094
Zixuan Zhou,Chunhua Qian,Weizhong Yuan
Flexible wearable sensors assembled from conductive hydrogels have received great attention due to their wide application in human-machine interfaces, medical and healthcare detection. However, the traditional conductive gel needs to be attached to the application surface with external force, and only respond to the single strain stimulus. Moreover, due to the existence of water, ordinary hydrogels cannot work at below zero temperatures, which severely limits the application of hydrogel-based flexible electronic devices. The flexible wearable epidermal sensors assembled by ultra-sensitive polyvinyl alcohol-tannic acid-eutectic gallium-indium (PVA-TA-EGaIn) hydrogels with adhesiveness, rapid self-healing, high electrical conductivity and mechanical properties , and temperature sensitivity. The rigid conductive hydrogel prepared by freeze-thaw cycles shows outstanding tensile/compressive strength (1.13 MPa/4.59 MPa) and toughness (1.9 MJ/m 3 ), and reveals excellent fatigue resistance . It also exhibited high conductivity (3.63 S m −1 ) and strain sensitivity (gauge factor = 2.59). In addition, the hydrogels maintained good flexibility and conductivity at −10 °C. Besides, the PVA-TA-EGaIn hydrogels shows remoldability, which greatly prolongs the service life of the gel. The composite hydrogels show the potential of building the next generation of multifunctional hydrogel-based flexible wearable sensors in human motion monitoring, voice recognition and medical diagnosis.
研究领域:
材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Yi Li,Hao Sun,Xinpeng Li,Baojun Lin,Hongyi Liu,Ce Liang
In response to the surface icing issues of infrastructure and industrial equipment in extreme low-temperature environments, this study overcomes the energy consumption and durability limitations of traditional anti-icing/de-icing technologies by developing a scalable photothermal-superhydrophobic dual-functional composite coating. The coating is constructed through a “surface-anchored assembly” strategy: graphene (Gr) with few layers is used as the photothermal conversion core, which is modified by polydopamine (PDA) and covalently bonded with octyltriethoxysilane (OTES)-modified titanium dioxide (TiO₂). This is then anchored onto a semi-cured epoxy resin matrix, achieving efficient enrichment and firm binding of functional particles on the surface. The resulting coating exhibits both broad-spectrum photothermal response and mechanically stable superhydrophobic properties (static contact angle >155°, − <5°), significantly enhancing anti-icing/de-icing performance. Density functional theory (DFT) calculations reveal the charge transfer mechanism driven by the work function difference (ΔΦ = 0.64 eV) at the Gr-TiO₂ interface, explaining the enhanced photothermal performance at the microscopic level. Moreover, the heat transfer mechanism during the anti-icing/de-icing process is analyzed through a thermal conduction model. This work provides an efficient, stable, and scalable solution for anti-icing/de-icing in extreme environments through a three-dimensional synergy of material design, process innovation, and mechanism analysis.
研究领域:
材料科学
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表面工程
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能源材料
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纳米科技
·
物理化学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Dingran Li,Huimin Zhang,Juntao Xie,Yaohua Li,Yang Ma,Aimin Chang
The La 1-x Ce x BaCo 2 O 5 (x = 0.05, 0.1, 0.15, 0.2) thermosensitive ceramics with negative temperature coefficient (NTC) were synthesized using a conventional solid-phase method. X-ray diffraction analysis (XRD) revealed that La 1-x Ce x BaCo 2 O 5 possesses an orthorhombic perovskite structure. Scanning electron microscopy (SEM) showed a uniform and dense ceramic microstructure, with grain size initially increasing and then decreasing as the Ce content rises. X-ray photoelectron spectroscopy (XPS) data reveal the presence of oxygen vacancies and Co 3+ /Co 2+ ion pairs within the material, showing concentrations that increase with Ce content. The resistance temperature profiles indicate the presence of a hybrid conductive mechanism in the material. In the temperature range of 2–20 K, the conductive mechanism of the material conforms to Mott's 3D VRH conduction model. When the temperature is 20–77 K, the conductive mechanism of the material is consistent with the small polariton conduction model. In addition, the mechanism of the mixed effect of oxygen vacancy concentration on the conductivity of the material is explained to elucidate the electron hopping transport conductivity mechanism of NTC thermal ceramics. First-principle calculations demonstrate that oxygen vacancies introduce new impurity energy levels and pathways for electron transport, enhancing the ceramics' electrical conductivity. These findings highlight the ceramic samples' favorable NTC characteristics and electrical conductivity across the temperature range 2–77 K, offering new possibilities for applications in extremely low-temperature NTC thermistors.
研究领域:
材料科学
·
凝聚态物理
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产品关联
DOI
高影响因子
Ceramics-Switzerland
·
2024
·Vol. 7
·期 3
·1043-1052
·
IF 2.7
Jianhua Wu,Tiantian Zhang,Xing Gao,Lei Ning,Yanhua Hu,Xiaojie Lou,Yunying Liu,Ningning Sun,Yong Li
Inorganic dielectric films have attracted extensive attention in the field of microelectronic and electrical devices because of their wide operating temperature range, small size, and easy integration. Here, we designed and prepared eco-friendly (1-x)Bi0.45Na0.45Ba0.1TiO3-xBi(Mg1/3Nb2/3)O3multifunctional ferroelectric thin films for energy storage and photovoltaic. The results show that Bi(Mg1/3Nb2/3)O3can effectively improve the energy storage performance. At x = 0.05, the energy storage density and efficiency are as high as 73.1 J/cm3and 86.2%, respectively, and can operate stably in a wide temperature range. The breakdown field strength of the thin films increased significantly, and the analysis showed that the addition of Bi(Mg1/3Nb2/3)O3caused a change in the internal conduction mechanism. At the same time, the generation of polar nanoregions increases the relaxation characteristics, thus improving the energy storage properties. In addition, the thin film material also has excellent ferroelectric photovoltaic properties. This work represents a new design paradigm that can serve as an effective strategy for developing advanced multi-functional materials.
研究领域:
材料科学
·
电子工程
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
Energy Storage Materials
·
2022
·
IF 20.831
Qiuyan Liu,Gaojing Yang,Xiaoyun Li,Simeng Zhang,Renjie Chen,Xuefeng Wang,Yurui Gao,Zhaoxiang Wang,Liquan Chen
Poly(vinylidene fluoride) (PVDF) is the most popular electrode binder in the current lithium ion batteries (LIBs). Depending on solvent content, polymer electrolytes are classified into solid polymer electrolyte (SPE; solvent-free) and gel polymer electrolytes (GPE; solvent-rich). PVDF-based electrolytes with high contents of solvent undisputedly belong to GPE. However, the affiliation (SPE or GPE) of the PVDF-based electrolyte with low content of “solvent” is in argument as its “solvent” cannot be eliminated till 80 °C in vacuum and its structure and ion transport mechanism remain unclear. By a series of studies, we demonstrate that this is actually a polymer electrolyte based on the interactions between the [solvent-Li + ] complex and the polymer in structure and in Li-ion transport mechanism. The “residual solvent” (N,N-dimethylformamide, DMF, for example) plays critical roles in constructing the polymer electrolyte and in determining its ion transport and therefore such electrolyte cannot be assigned to any of the known polymer electrolytes. The Li + -associated DMF becomes difficult to be eliminated while the DMF-dehydrofluorinated PVDF has a larger dielectric constant, enhances the dissociation of the lithium salt and interacts with the [DMF-Li + ] complex, the charge carrier of the electrolyte. These [solvent-Li + ] complex-based polymer electrolytes have high ionic conductivity (10 −4 S cm −1 at room temperature), Li-ion transference number (0.44) and Young's modulus (45.87 MPa) and will find important applications in the solid lithium batteries and as an ion-conducting binder for the electrodes. These findings will enrich the gallery and deepen the fundamental understandings of the polymer electrolytes, spurring designing of novel electrolytes.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）