Journal of Materials Chemistry B
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2020
·Vol. 8
·期 36
·8282-8293
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IF 5.344
Ruihua Cui,Fangping Chen,Yujiao Zhao,Wenjie Huang,Changsheng Liu
Hemorrhage remains one of the direct causes of high mortality. The development of ideal hemostatic materials with sound ability to deal with severe wound is urgent needed. Although starch-based hemostatic powder has been widely used, hydrous physiological environments severely hamper its binding to the target tissue, thereby limiting the effectiveness in hemostasis. Herein, inspired by mussel adhesive protein, a novel injectable tissue-adhesive hydrogel (St-Dopa hydrogel) composed of starch, succinic anhydride and dopamine was developed in situ by enzymatic crosslinking. The results show that St-Dopa hydrogels were intimately integrated with biological tissue and formed robust barriers to reduce blood loss. St-Dopa hydrogels exhibited superior capacity for in vitro and in vivo hemostasis as compared with chitin hydrogels. In addition to the ease of operation, St-Dopa hydrogels exhibited rapid sol–gel transition, porous microscopic morphology, good swelling ratio and biodegradability, tissue-like elastomeric mechanical properties and excellent cyto/hemo-compatibility. These results suggest that this newly developed St-Dopa hydrogel is a promising biological adhesive and hemostatic material.
研究领域:
生物医学工程
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材料科学
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创伤修复
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2020
·
IF 5.065
Cheng Yuan,Deng-Jing Chen,Qiu-Xiang Ye,Kai Xiao,Li-Sheng Hao,Yan-Qing Nan
The CO 2 /N 2 -triggered switchable sol–gel transition based on sodium deoxycholate (NaDC) and sodium chloride (NaCl) aqueous solutions has been investigated using both experiments and molecular dynamics (MD) simulations. The effects of CO 2 on the phase behavior, viscosity, pH, electrical conductivity, and microstructure of the NaDC/NaCl mixed system were explored. The mixed system exhibits a recycled CO 2 /N 2 response, and switching between solution state and gel state with six orders of magnitude variation in shear viscosity was achieved within a narrow pH range of 7.82–7.20. The FT-IR and 1 H NMR spectra of the mixed system before and after CO 2 bubbling were measured. The experimental results indicate that NaDC is not directly protonated to deoxycholic acid by the small amount of CO 2 present; instead, an acid salt structure with a strong hydrogen bond , that is, [RCOOH⋯OOCR] − , is formed. MD simulation results reveal that, in the aqueous mixed NaDC/NaCl/CO 2 system, three types of bridging hydrogen bonds between two deoxycholate (DC − ) anions and one H 3 O + or HCO 3 − ion are key factors for the formation of hydrogels. These bridging hydrogen bonds promote the formation of DC − pairs bridged by H 3 O + or HCO 3 − ions (including the acid salt structure) and are beneficial to the growth of micelles and formation of hydrogels. It is worth noting that the bridging hydrogen bond connected by HCO 3 − ions is an aspect of CO 2 -induced hydrogels that distinguishes them from acid-induced hydrogels. In addition, the results indicate that CO 2 and NaCl have a synergistic effect when inducing hydrogel formation. Based on experiments and MD simulations, a CO 2 /N 2 -switchable sol–gel transition mechanism for an aqueous mixed NaDC/NaCl system has been proposed.
研究领域:
化学
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材料科学
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2024
·
IF 8.3
Yong Liu,Kaiyuan Wang,Wenwen Ren,Nannan Gao,Juanjuan Li,Hao Wang
Hydrogel-based dressing materials offer significant potential in expediting skin wound healing. Nevertheless, they face several challenges: poor adhesion to wound tissues, difficulties in preservation under ambient conditions, and limited multifunctionality to support all wound healing stages. In this work, a dry patch is designed to address these persistent issues by featuring an in situ solid-to-gel transformation and Janus wet tissue adhesiveness. The HGP patch integrates a wet adhesive layer combining dopamine-conjugated hyaluronic acid (HD) and poly(acrylic acid) (PAA), a drug-loading layer comprising gelatin (Gel), and a nonadhesive gelation layer of poly(vinyl alcohol) (PVA) and sodium alginate (SA). This hierarchical structural design confers exceptional wound adhesion, hemostatic capabilities, and antibacterial and antioxidant activities, as well as immune regulatory properties. These attributes collectively support accelerated skin wound healing, particularly in cases complicated by bacterial infections. This research charts an approach to engineer hydrogel-based wound dressings through on-site hydrogel formation, thus advancing the treatment of wounds afflicted with complex infections.
研究领域:
生物材料学
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医学工程
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药剂学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
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2019
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IF 0
Peihong Li,Chunling Zhang,Rui Li,Lijie Qu,Xueyan Dai,Yanlong Sui,Jiazi Hou
Pluronic F127 is a thermosensitive polymer that has been extensively studied and utilized in biomedicine. To improve the gelation properties of F127, α-cyclodextrin was introduced by physical interactions, such as forming inclusion complexes, hydrogen bond self-assembly, and hydrophobic interactions, to prepare F127−α-CD hydrogels. This study explored the temperature-dependent sol–gel transition behavior, gelation mechanism, interior morphology, and controlled release of the anticancer drug 5-fluorouracil. Results showed that hydrogel could be obtained at 1.0%–8.0% weight content of F127. The cross-linking points in this system were PEO−α-CD microcrystalline region and micelle with poly(propylene oxide) as the core. The network inside F127−α-CD hydrogels made it stable and conducive for controlled release. Therefore, this hydrogel is a promising drug release system.
研究领域:
药剂学
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生物材料
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产品关联
DOI
PubMed
Polymers
·
2025
·Vol. 17
·期 8
·1065
·
IF 4.9
Qing Yang,Haiyang Yu,Xiaolu Wang,Yunze Li,Dan Li,Fu Guo
New 3D printing aerogel materials are environmentally friendly and could be used in environmental protection and biomedical fields. There is significant research interest in 3D printing cellulose-based aerogels since cellulose materials are biocompatible and are abundant in nature. The gel-like nature of the cellulose water suspension is suitable for 3D printing; however, the complexity and resolution of the geometry of aerogels are quite limited, mainly due to the inks’ low viscosity that fails to maintain the integrity of the shape after printing. To address this limitation, a carefully optimized formulation incorporating three key ingredients, i.e., nanofibrils (TEMPO-CNFs), 2,2,6,6-tetramethyl-1-piperidinyloxy modified cellulose nanocrystals (TEMPO-CNC), and sodium carboxymethyl cellulose (CMC), is utilized to enhance the viscosity and structural stability of the ink. This combination of cellulose derivatives utilizes the electrostatic repulsive forces between the negatively charged components to form a stable and uniformly distributed suspension of cellulose materials. Our ink formulations improve printability and shape retention during 3D printing and are optimal for DIW printing. We print by employing an all cellulose-based composite ink using a modified direct ink writing (DIW) 3D printing method, plus an in situ freezing stage to form a layer-by-layer structure, and then follow a freeze-drying process to obtain the well-aligned aerogels. We have investigated the rheological properties of the ink formulation by varying the concentration of these three cellulose materials. The obtained aerogels exhibit highly ordered microstructures in which the micropores are well-aligned along the freezing direction. This study demonstrates a strategy for overcoming the challenges of 3D printing cellulose-based aerogels by formulating a stable composite ink, optimizing its rheological properties, and employing a modified DIW printing process with in situ freezing, resulting in highly ordered, structurally robust aerogels with aligned microporous architectures.
研究领域:
材料科学
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环境科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2025
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IF 8.2
Nan Li,Zhaoqing Lu,Doudou Ning,Li Hua,Songfeng E
One-dimensional (1D) heterocyclic aramid nanofiber (HANF)-based films have garnered significant research interest due to their excellent mechanical, insulative, and high temperature resistance performances. In this study, we developed an innovative sol–gel transition strategy for fabricating continuous HANF films with highly aligned nanostructures and pronounced mechanical anisotropy via blade-coating. A bottom-up strategy of low-temperature solution polycondensation was used for the synthesis of polymeric precursors, which were self-assembled into nanofibers through hydrogen-bonding-induced aggregation. Notably, methoxy poly(ethylene glycol) (mPEG) was incorporated into the poly(p-phenylene-benzimidazole-terephthalamide) (PBIA) polymerization to modulate the self-assembly process. The resulting mPBIA nanofiber film demonstrated remarkable anisotropic behavior, which exhibited a tensile strength of 184 MPa with divergent rupture strains of 5.4% (parallel to coating direction), 33.2% (45°), and 50.6% (perpendicular) relative to the blade-coating orientation. Post-hot-pressing treatment, the mPBIA film achieved an impressive dielectric breakdown strength of 169.4 kV mm–1, coupled with exceptional thermal stability and efficient heat dissipation capability. This scalable manufacturing approach establishes HANF films as a promising platform for developing advanced composite materials with tailored functionalities.
研究领域:
材料科学
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纳米技术
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高分子化学
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电气工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
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2014
·Vol. 70
·期 3
·355-360
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IF 1.547
Gao Xiaoju,Cui Hongtao
Herein, addition reaction occurred between glycidol and partially hydrolyzed Ti 4+ complexes provides a opportunity to obtain dry anatase nanopowder with high redispersity in water. This property is considered to be originated from the two OH groups located in the two ends of glycidol resulted chlorinated propandiol molecules. In aqueous solution, the two OH groups are respectively connected with particle surface and external free water by the formation of hydrogen bonds, resulting in high water redispersity of nanoparticles. Due to the much less amount of chlorinated propandiol molecules than adsorbed molecule water on particle, the wide space between organic molecules facilitates the mutual physical surface touch of individual particles to form hydrogen bond between them. A novel property is then obtained for surface modified titania nanoparticles, which is the gelation of redispered nanoparticles in aqueous solution.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Hongyu Guo,Linfang Liang,Jiayi Guo,Liangbin Lin,Fafu Yang
The metal-coordination self-assemble system played an important role on constructing novel supramolecular smart-response materials. Although the single and double-response materials based on metal-induced self-assembly had been studied extensively, the triple responses for this kind of supramolecular material was seldom reported. In this work, the first metal-induced self-assemble system with triple responses on photophysical, liquid crystalline and gel properties was presented based on Hg 2+ -coordination tetraphenylene dimer ( Bis-TPE ). Bis-TPE was prepared by bridging two alkyl-substituted tetraphenylene with amido chain. It possessed the fluorescence response from the strong emission for Bis-TPE to the faint emission for Bis-TPE -Hg 2+ complex. The self-assemble mechanism of Bis-TPE -Hg 2+ was clarified as that Hg 2+ was located in the cavity of the amido-ether chain of Bis-TPE . The Hg 2+ -induced mesomorphic transition was also observed from smectic mesophase for Bis-TPE to hexagonal columnar mesophase for Bis-TPE -Hg 2+ complex. The unique Hg 2+ -induced gel transition was further distinguished from low-order spherical morphology for Bis-TPE to high-order fibrous morphology for Bis-TPE -Hg 2+ complex. The maximum fluorescence wavelength exhibited the giant shift from 494 nm for Bis-TPE in gel to 606 nm for Bis-TPE -Hg 2+ in gel. This kind of triple responses on photophysical, liquid crystalline and gel properties for metal-coordination self-assemble system was described for the first time, affording a new idea on design of new multiple-response materials with unique properties.
研究领域:
超分子化学
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材料科学
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配位化学
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Tingting Xia,Xueting Li,Youtong Wu,Xihua Lu
Thermally-induced in-situ gelation of polymers and nanogels is of significant importance for injectable non-invasive tissue engineering and delivery systems of drug delivery system . In this study, we for the first time demonstrated that the interpenetrating (IPN) nanogel with two networks of poly (N-isopropylacrylamide) (PNIPAM) and poly (N-Acryloyl- l -phenylalanine) (PAphe) underwent a reversible temperature-triggered sol-gel transition and formed a structural color gel above the phase transition temperature (Tp). Dynamic light scattering (DLS) studies confirmed that the Tp of IPN nanogels are the same as that of PNIPAM, independent of Aphe content of the IPN nanogels at pH of 6.5 ∼ 7.4. The rheological and optical properties of IPN nanogels during sol-gel transition were studied by rheometer and optical fiber spectroscopy. The results showed that the gelation time of the hydrogel photonic crystals assembled by IPN nanogel was affected by temperature, PAphe composition, concentration, and sequence of interpenetration. As the temperature rose above the Tp, the Bragg reflection peak of IPN nanogels exhibited blue shift due to the shrinkage of IPN nanogels. In addition, these colored IPN nanogels demonstrated good injectability and had no obvious cytotoxicity. These IPN nanogels will open an avenue to the preparation and thermally-induced in-situ gelation of novel NIPAM-based nanogel system.
研究领域:
材料科学
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生物医学工程
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组织工程
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产品关联
DOI
PubMed
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2019
·
IF 7.279
Lijun Geng,Xudong Yu,Yanqiu Wang,Yajuan Li,Fengjuan Shen,Jujie Ren
Herein, instant and precise control of fluorescent emission color and transmittance could be carried out by ultrasound-promoted gel-to-gel transition of naphthalimide derivatives containing C N unit. It is proved that ultrasound triggered an irreversible and efficient configuration transformation of N1 from “trans to cis” form in gel state, which is stabilized by intermolecular hydrogen bonding interaction and not observed in the solution state.
研究领域:
材料科学
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化学
·
生物学
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产品关联
DOI
PubMed
高影响因子
POLYMER TESTING
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2021
·
IF 4.282
Ziyuan Fang,Kun Qiao,Yansen Wang,Yudong Zheng,Wei He,Yajie Xie,Huiyi Yang
Alginate hydrogels have the most extensively explored injection system among natural molecular. The injectable alginate hydrogel has special physical and biological properties without toxicity, therefore, it has been served as minimally invasive treatments to treat various irregular defects. However, the inconvenient truth is low formability and poor mechanical properties of injectable alginate hydrogels; besides, there are little relevant studies about controlling, measurement and analysis of the sol-gel transition and degradation process. We synthesized an injectable nanocomposite alginate hydrogel, used specific methods and equipment to regulate and evaluate the sol-gel transition of the hydrogel, moreover, we researched the degradation behaviour using scanning electron microscope, nano-indenter and titration analysis. The results showed that gelation time and mechanical properties could be regulated and effectively described. Compression properties of the hydrogels increased to 150%–300% compared with common alginate hydrogels, in addition, the degradation behaviour with ions release could be regulated by the formula. The results will be propitious to solve problems in quality control of hydrogel manufacturing engineering and the nanocomposite hydrogels with good biocompatibility will have great potential for multifunctional biological scaffolds and tissue engineering.
研究领域:
生物材料学
·
组织工程学
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Haotian Shi,Teng Qiu,H. Daniel Ou-Yang,Huangbing Xu,Qingchuan Lu,Ying Zheng,Kexin Liu,Lifan He,Longhai Guo,Xiaoyu Li
A temperature sensitive sol-gel transition induced by the self-assembly of amphiphilic copolymers and its application in industry have been the objects of increasing study. We demonstrate here a two-step, reversible addition-fragmentation chain transfer (RAFT) polymerization of an ABA-type copolymer consisting of poly( N,N -dimethylacrylamide)- b -poly(diacetone acrylamide)- b -poly( N,N -dimethylacrylamide) (PDMAA- b -PDAAM- b -PDMAA). This copolymer can be easily dispersed in water, and this dispersion is critical for its lower critical solution temperature (LCST)-type sol-gel transition, which was monitored using dynamic light scattering (DLS), transmission electron microscopy (TEM), and rheology analysis, in addition to temperature-dependent 1 H nuclear magnetic resonance ( 1 H NMR) and Fourier transform infrared spectroscopy (FTIR). Results revealed an abnormal sphere-to-worm micellar transition of this ABA copolymer at the LCST point, which could be affected by the length of the PDAAM block (B-block), the length as well as the distribution of the PDMAA block (A-block), and the concentration of the copolymer dispersion. Thus, copolymer dispersion could be feasibly used for drug loading at a low temperature, which could then be transformed into a gel at an elevated temperature. The loading and controllable release of the model drug of paracetamol into and out of a copolymer gel was further determined. The sustained release behavior was also studied using the Rigter-Peppas model.
研究领域:
材料科学
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生物医学工程
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高分子化学
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DOI
高影响因子
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