Biomedicines
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2021
·Vol. 9
·期 9
·1138
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IF 6.081
Xiaofeng Cao,Wufei Ge,Yihu Wang,Ming Ma,Ying Wang,Bing Zhang,Jianing Wang,Yanchuan Guo
Although bone repair scaffolds are required to possess high radiopacity to be distinguished from natural bone tissues in clinical applications, the intrinsic radiopacity of them is usually insufficient. For improving the radiopacity, combining X-ray contrast agents with bone repair scaffolds is an effective method. In the present research, MgNH4PO4·H2O/SrHPO43D porous composite scaffolds with improved radiopacity were fabricated via the 3D printing technique. Here, SrHPO4was firstly used as a radiopaque agent to improve the radiopacity of magnesium phosphate scaffolds. X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS) were used to characterize the phases, morphologies, and element compositions of the 3D porous composite scaffolds. The radiography image showed that greater SrHPO4contents corresponded to higher radiopacity. When the SrHPO4content reached 9.34%, the radiopacity of the composite scaffolds was equal to that of a 6.8 mm Al ladder. The porosity and in vitro degradation of the porous composite scaffolds were studied in detail. The results show that magnesium phosphate scaffolds with various Sr contents could sustainably degrade and release the Mg, Sr, and P elements during the experiment period of 28 days. In addition, the cytotoxicity on MC3T3-E1 osteoblast precursor cells was evaluated, and the results show that the porous composite scaffolds with a SrHPO4content of 9.34% possessed superior cytocompatibility compared to that of the pure MgNH4PO4·H2O scaffolds when the extract concentration was 0.1 g/mL. Cell adhesion experiments showed that all of the scaffolds could support MC3T3-E1 cellular attachment well. This research indicates that MgNH4PO4·H2O/SrHPO4porous composite scaffolds have potential applications in the bone repair fields.Keywords:magnesium phosphate;strontium hydrogen phosphate;3D printing;scaffolds;radiopacity
研究领域:
生物医学工程
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材料科学
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组织工程
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
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IF 4.4
Weihong Xue,Bo Dai,Kuan Zhai,Haipeng Song,Wen Wen,Shuangmeng Zhai
The Raman spectra and thermal expansion of MgP 2 O 6 metaphosphate were investigated at various temperatures up to 1073 K at ambient pressure. No temperature-induced phase transition was observed in this study. The effect of temperature on the Raman active vibrations and unit cell parameters was determined. All the observed Raman active bands of MgP 2 O 6 showed linear temperature dependences in the range of −2.61 × 10 −2 ∼ −0.49 × 10 −2 cm −1 K −1 . The thermal expansion coefficient of MgP 2 O 6 was estimated to be 3.21(2) × 10 −5 K −1 . An axial anisotropic thermal expansion exists and the c -axis shows the smallest thermal expansion. The isobaric mode Grüneisen parameters of MgP 2 O 6 were calculated. The obtained results were compared with other compounds in the MgO-P 2 O 5 system.
研究领域:
材料科学
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物理学
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DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
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2020
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IF 3.83
Yufei Tang,Cong Wu,Ping Zhang,Kang Zhao,Zixiang Wu
A sintering-free magnesium phosphate cement (MPC) with an arbitrary shape is potentially used as a bone implant material , especially with complex shapes. However, the high degradation rate of MPC may lead to the degradation of mechanical properties . In this study, graphene (G)/barium titanate (BT)/MPC composites were fabricated by introducing the piezoelectric phase BT and conductive phase G into MPC, which exhibited the piezoelectric effect after polarisation. The negative surface of the composite may attract Ca 2+ and Mg 2+ to mineralise rapidly, thereby reducing and improving its degradation rate and mechanical properties, respectively. The contents of additional G and BT were optimised. When BT and G contents were 50 mol% and 0.5 wt%, respectively, the piezoelectric coefficient of the composites increased to 6.31 pC/N, which is an increase of 421% without the addition of G. The results of in vitro degradation and mineralisation in simulated body fluids (SBF) showed that introducing BT and G could effectively slow down the degradation rate, promote mineralisation on the composite surface, and enhance the impact on bone integration.
研究领域:
生物材料学
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医学工程
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DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
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2021
·Vol. 27
·期 41
·10666-10676
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IF 5.236
Peng Zhang,Shaonan Xu,Yan Wang,Wei Zhang,Wenqing Li,Cundi Wei,Peiping Zhang,Shiding Miao
Graphical One man‘s trash is another man‘s treasure : A novel template strategy allows fibrous struvite—a composite Pd/Mg 2 P 2 O 7 with a mesoporous structure and an ultrahigh surface area—to be synthesized from wastewater. The prepared Pd/Mg 2 P 2 O 7 nanowires showed excellent performance in the selective hydrogenation of nitrobenzenes. This strategy provided a new pathway for synthesizing highly efficient catalysts as well as a solution for alleviate eutrophic pollution caused by N- and P-containing substances in wastewater. A highly efficient heterogeneous catalyst Pd/Mg 2 P 2 O 7 was fabricated by combining palladium nanoparticles (PdNPs) and mesoporous Mg 2 P 2 O 7 fibers/rods. Mg 2 P 2 O 7 fibers with ultra-high specific surface area were prepared from struvite as templates, which were synthesized from waste water containing N- and P-containing pollutants. This strategy provided a novel pathway for developing advanced catalysts from eutrophication-polluted water. The composite Pd/Mg 2 P 2 O 7 showed brilliant performance in selective hydrogenation of nitro aromatics to give anilines. As an example of nitrobenzene hydrogenation, the conversion to aniline and selectivity were found to reach almost 100 % at a temperature of T =90 °C and under a pressure of P =2.0 MPa. The superior performance was found to originate from PdNPs, which were boosted by electron transfer afforded by the nanofiber Mg 2 P 2 O 7 supports. The favorable adsorption of withdrawing groups (−NO 2 ) was realized by synergistic effects between Pd and oxygen vacancies provided by pyrolysis of struvite. The catalyst remained stable after cycles of reuse with little degradation in catalytic performance.
研究领域:
环境科学
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催化化学
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DOI
PubMed
高影响因子
MATERIALS & DESIGN
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2022
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IF 9.417
Bocheng Lei,Xiaobo Gao,Ran Zhang,Xin Yi,Qing Zhou
The development of a scaffold that can be quickly prepared and used to repair maxillofacial bone defects is an urgent clinical need. 3D printing technology can prepare personalized bone defect substitutes according to the computed tomography (CT) data of the patient's defect location. Magnesium is a bioactive molecule that plays an important role in the process of bone repair. In this study, different contents of magnesium phosphate (Mg 3 (PO 4 ) 2 ) were incorporated into polycaprolactone (PCL), and a bone defect repair scaffold was prepared using 3D printing technology. In vitro results showed that PCL scaffolds containing 20 % Mg 3 (PO 4 ) 2 (PCL#20MgP) had the strongest ability to promote osteogenic differentiation. Micro-CT and histological staining results of the repair of tibial defects in rats also further proved that the PCL#20MgP scaffold had strong bone formation ability in vivo . The PCL#20MgP scaffold was used to repair the rabbit maxillofacial bone defect. The Micro-CT results also confirmed that PCL#20MgP had a better osteogenesis effect than the PCL scaffold. The PCL#20MgP scaffold has good clinical application prospects in the field of maxillofacial bone defect repair.
研究领域:
生物医学工程
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组织工程
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骨科
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DOI
高影响因子
ADVANCED ENGINEERING MATERIALS
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2025
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IF 3.3
Qiaoyun Liu,Yifeng Yu,Yuhang Liu,Liangjie Yuan,Zheng Wang,Baiwen Qi,Aixi Yu
As the most abundant rare earth element, cerium (Ce) can endow implanted bone repair materials with excellent performance. With magnesium phosphate composite material (MPC) as models, Ce is introduced to improve the osteogenic induction of MPC. A series of Ce-doped MPC (CMPC) with Ce molar ratios of 1, 3, and 5% can be successfully synthesized by the precursor method. The obtained results indicate that CMPC has advantages such as reliable biosafety, excellent osteogenic activity, and excellent mechanical properties. When the content of Ce is 1%, the synergistic effect of Ce 4+ and Mg 2+ released from CMPC-1 is more conducive to promoting cell proliferation and enhancing osteogenic activity, which can accelerate the deposition of calcium junctions and promote the repair of bone defects. These results will provide new routes to improve the bioactivity of CMPC, thereby promoting its clinical application research.
研究领域:
生物材料
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生物医学工程
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组织工程
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材料科学
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产品关联
DOI
高影响因子
International Journal of Applied Ceramic Technology
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2024
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IF 1.8
Junying Chen,Xingze Duan,Jing Wen,Tingting Ma,Jianguo Liao
Magnesium phosphate bone cement (MPBC) is a bone repair material that has been extensively studied. For better availability of clinical medicine, its degradation rate needs to be effectively controlled. Hydroxypropyl methylcellulose (HPMC) has often been used as a drug carrier for controlled drug release. This property was utilized to influence the release kinetics of MPBC. This work investigated the degradation mechanism of MPBC controlled by HPMC. It was found that MPBC samples with 3 wt. % HPMC had the optimal properties. In this case, the setting time was 11 min and the maximum strength was 63.9 ± 2.5 MPa. The study found HPMC primarily controlled the degradation of MPBC hydration products via the combined actions of gradual diffusion, and release of MPBC hydration products, which subsequently caused the swelling, corrosion, and dissolution of the HPMC skeleton. Besides, the results showed that HPMC-modified MPBC has good bioactivity, which is beneficial to bone repair. This bioactive HPMC-modified MPBC showed a controllable degradation rate and proper mechanic properties, which may be applied to bone repair.
研究领域:
材料科学
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医学工程
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生物医学
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产品关联
DOI
高影响因子
CORROSION SCIENCE
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2020
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IF 6.479
Yufei Tang,Lixia Zhu,Ping Zhang,Kang Zhao,Zixiang Wu
The surface of a medical magnesium alloy treated by micro-arc oxidation was coated with magnesium phosphate-based bio-piezoelectric bone cement. The high tensile adhesive strength of the obtained composite coating was 6.83 MPa due to mechanical locking and its chemical reaction. The corrosion degradation property of the bio-piezoelectric composite coating in simulated body fluid improved because the negative surface charge after polarization led to the balance between degradation and deposition rates during apatite deposition. After the coating was soaked in simulated body fluid (SBF) for 7days, the weight loss rate of the sample considerably decreased to 1.03%, and the average corrosion rate decreased to 3.33 mm/year.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Dongping Song,Tao Huang,Kai Chen,Jialin Cui,Qingyang Xu,Chengyu Yan,Chengzhe Yang,Shaohang Wan,Minfeng Tao
In this study, the magnesium phosphate cement (MPC) coupling with graphene nanosheets (GNP) was employed to solidify municipal solid waste incineration fly ashes (MSWI-FA) and stabilize the contaminants of heavy metals (HMs) and chloride salts in the matrix. The maximum compressive strength of 45.62 MPa and the minimum leaching concentration of 0.012, 0.0064, 0.00079, 0.0045, and 0.048 mg/L for Zn, Cu, Cd, Pb, and total Cr and 0.86 g/L for chloride were obtained from the GNP-MPC-MSWI-FA-cemented matrix in the orthogonal tests and toxicity-leaching experiments, respectively. MSWI-FA significantly changed the MPC hydration process. The influence of MPC on the speciation transformation of HMs was more prominent than that of GNP. Fick's theory model was appropriate in fitting the whole leaching process of HMs and dissolvable chloride species from the matrix under acid-immersion conditions. Both K-struvite and Phase-5 were formed in the matrix in mineral analysis, verifying the formation of both MPC and magnesium oxychloride cement (MOC). The chloride salts in the MSWI-FA facilitated the self-cementation of MOC from light-burnt magnesia in MPC. The mechanisms including the formation of phosphate precipitation, gelation encapsulation, and chemical hydration brought by MPC attributed to effective solidification/stabilization of HMs and chloride in the MSWI-FA.
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高影响因子
Frontiers in Materials
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2022
·
IF 3.985
Mao Qiuyi,Zhu Bowen,Zhuang Hai,Bu Shoushan
A new prototype of hybrid silk fibroin and sodium alginate (SF-SA) based osteogenic hydrogel scaffold with a concentration of 2.5% magnesium phosphate (MgP) based gel was prepared with the assistance of an extrusion-based three-dimensional (3D) printing machine in this study. To determine the optimum ratio of MgP-based gel in the hydrogel, a series of physical and biochemical experiments were performed to determine the proper concentration of MgP in two-dimensional hydrogel films, as well as the cell compatibility with these materials in sequence. The SF-SA hydrogel with 2.5wt% magnesium phosphate (SF-SA/MgP) stood out and then was used to fabricate 3D hydrogel scaffolds according to the consequences of the experiments, with SF-SA hydrogel as a control. Then the morphology and osteogenic activity of the scaffolds were further characterized by field emission scanning electron microscope (SEM), calcium mineralization staining, and reverse transcription-polymerase chain reaction (rt-PCR). The SF-SA/MgP hydrogel scaffold promoted the adhesion of rat mesenchymal stem cells with higher degrees of efficiency under dynamic culture conditions. After co-culturing in an osteogenic differentiation medium, cells seeded on SF-SA/MgP hydrogel scaffold were shown to have better performance on osteogenesis in the early stage than the control group. This work illustrates that the 3D structures of hybrid SF-SA/MgP hydrogel are promising headstones for osteogenic tissue engineering.
研究领域:
生物医学工程
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组织工程
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材料科学
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细胞生物学
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2020
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IF 3.573
Kai Ge,Yuanhui Ji,Shuai Tang
The influence of various factors (e.g., temperature, stirring speed, pH, and alginic acid concentration) on the crystallization kinetics of magnesium ammonium phosphate hexahydrate (MAP) was evaluated. The chemical potential gradient models were used to analyze the MAP crystallization mechanism and predict MAP crystallization kinetics. It was found that the temperature and stirring speed mainly influenced the kinetic rate constant, while alginic acid additives mainly influenced the thermodynamic driving force of MAP. The pH mainly influenced both the rate constant and the thermodynamic driving force, which is the key influencing factor of the crystallization rate and performance of MAP. The theoretical modeling indicated that the MAP crystallization mechanism was dominated by the adhesive-type growth mechanism. Furthermore, the crystallization kinetics of MAP was successfully predicted as a function of alginic acid concentration with high accuracy. This work is expected to provide important information for selecting appropriate operating parameters to control the performance of MAP in practical applications.
研究领域:
化学工程
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材料科学
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物理化学
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产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Long Zhang,Mingqi Zhao,Siyu Yang,Siyu Li,Tingbin Zhang,Hongze Zhang,Yiqian Gong,Mingjun Li,Huan Zhou,Huipeng Li,Lei Yang
Intervertebral disc degeneration (IVDD) is recognized as a major cause of back pain, yet the underlying mechanism of degeneration remains unclear. Although hydrogels have been explored to replace the nucleus pulposus (NP) to delay IVDD, mechanical incompatibility may exacerbate the degeneration. Moreover, a single mechanical support cannot effectively address the vicious cycle between damaged NP cells and the pathological microenvironment. To address these challenges, a mineralized liposome inspired by natural diatoms was developed. Liposome loading melatonin (MT) was utilized to mimic the core of diatoms, while the mineralized magnesium pyrophosphate shell incorporated with epigallocatechin gallate (EGCG), which decorated the liposome surface, was utilized to mimic the frustules of diatoms. After that, a mechanically matched hydrogel named PGB was prepared and acted as storage for loading the mineralized liposome. The mineralized layer of the liposome could be rapidly disintegrated in the IVDD acidic microenvironment, and the quickly released magnesium ions (Mg2+) could maintain NP cells active while the released EGCG could scavenge reactive oxygen species (ROS) in the NP microenvironment. Meanwhile, the continuously released liposome encapsulated with MT could adjust extracellular matrix (ECM) synthesis after cellular up by NP cells, achieving NP repair by an inside-out cooperation strategy. The hydrogel platform provides insight into the treatment of IVDD.
研究领域:
生物医学工程
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生物材料
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组织工程
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骨科
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药物递送
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）