Green Analytical Chemistry
·
2025
·
IF 6.2
Shuang Sun,Yijie Fu,Xinming Huo,Mi Luo,Quan Yu
Analysis of psychotropic drugs in blood is a suitable method to assess the effectiveness of patient treatment and the safety of drug dosage. Direct analysis of whole blood using mass spectrometry (MS) faces challenges due to the complex matrix and components in the sample. In this study, we developed a practical analytical strategy based on a miniature MS instrument for on-site detection of psychotropic drugs in blood. In particular, samples were first treated through a simplified and optimized extraction process and then analyzed by a miniature MS mounted with a capillary self-aspirating electrospray ionization source. This method reduced the consumption of samples and reagents while offering high accuracy and sensitivity, with a limit of detection as low as 0.1 ng/mL. We subsequently implemented the detection of venlafaxine and O-desmethyl venlafaxine in some whole blood samples. The results showed good agreement with those obtained by HPLC-MS, demonstrating the accuracy and practicality of the proposed analytical protocol.
研究领域:
分析化学
·
生物医学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yifei Sun,Hang Su,Wei Xiong,Luhong Wen
Water is essential for maintaining human health and ecosystem stability, as it forms the foundation for biological processes. Monitoring pesticides in environmental water remains a critical area of research due to the significant importance of water quality. In this study, a lab-made thermal desorption split-type dielectric barrier discharge ionization source (TD-ST-DBDI) platform was developed, enabling the rapid and effective detection of surface water contaminants, such as amides, triazines, and carbamate pesticides, under environmental conditions without the need for complex pretreatment. Compared to conventional laboratory methods, this approach offered enhanced convenience and efficiency in analysis. Using the established quantitative method, we achieved limit of detections (LODs) ranging from 0.03 to 3 μg/L, limit of quantifications (LOQs) ranging from 0.10 to 10 μg/L, with relative standard deviations (RSDs) of less than 9 %, and linear correlation coefficients (R 2 ) of 0.99 for these pesticides. To track contamination trends over time, a multi-indicator risk assessment model incorporating various factors was developed to evaluate the potential ecological and human health risks of water pollution, revealing that pesticide pollution risks fluctuated over time. This finding provides new insights on monitoring large-scale surface water and exploring the impact of exposure to chemical pollutants on human health.
研究领域:
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 9
·期 7
·3976-3984
·
IF 11.301
Zhongliang Huang,LongLong Fan,Bin Chen,Shu-feng Zhou,Jiale Huang,Qingbiao Li,Guowu Zhan
The controlled growth of MOF crystals in a confined space has long been a challenge. In this contribution, we present a facile strategy for the confined growth of MOF crystals in a mesoporous silica shell by pre-installing a metal stock inside the cavity while transporting organic linkers through the permeable shell. Remarkably, the size and shape of the confined MOF crystals could be controlled effectively by adjusting the synthesis parameters. The obtained MOF@mSiO2 composites could further be functionalized with a range of surfactant-free metal nanoparticles (MNPs, e.g., Au, Pd, and Ag) via galvanic replacement reactions on the encapsulated Cu2O surface during a one-pot preparation. This led to ultrafine MNPs embedded within the MOF matrix. The construction of the MOF and the galvanic replacement reaction occurred on similar time scales, and the Cu2O cores are believed to play dual roles in the synthesis: (i) providing a source of copper ions for building MOFs, and (ii) serving as a reductant to form noble MNPs which in turn significantly accelerated the formation kinetics of MOF crystals (to within 1 minute). Furthermore, it was also demonstrated that the encapsulated MOFs/MNPs within the mSiO2 shells were highly accessible to the general gas/liquid molecules and exhibited excellent catalytic activity for several oxidation reactions.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
JOURNAL OF PHYSICS D-APPLIED PHYSICS
·
2022
·Vol. 55
·期 48
·485202
·
IF 3.409
Kun Liu,Xiaohan Zhang,Xiongfeng Zhou,Xinming Huo,Xiaohao Wang,Kostya (Ken) Ostrikov
This work reported an air atmospheric pressure plasma jet served as an ion source for nonvolatile solid analysis, which allows a unique capability to achieve thermal desorption and ionization simultaneously without complex devices, inert gas, or solvents. Owing to precise amount of heat generated by plasma jet, nonvolatile analytes were thermally released from solid surfaces without the assistance of secondary desorption equipment. According to the mass spectra and Fourier transform infrared spectrum, [M + H]+ and [M + NO3]− ions were the major analyte ions in the positive-ion and negative-ion modes, respectively. The applied voltages, discharge currents, and gas temperatures of plasma jet were measured, and found to be positively correlated with the mass spectra signal intensity of the samples, while the added resistances and gas flow rate were negatively correlated with the signal intensity. The influence mechanisms of analytes natures coupling physical parameters of plasma jet on detection performance were revealed. The prospect of quantitative testing was confirmed by the linear relationship between the peak intensity and sample mass.
研究领域:
分析化学
·
质谱技术
·
等离子体科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2016
·
IF 3.926
Haiyang Zhang,Junjie Ou,Yinmao Wei,Hongwei Wang,Zhongshan Liu,Hanfa Zou
A hybrid fluorous monolithic column was simply prepared via photo-initiated free radical polymerization of an acrylopropyl polyhedral oligomeric silsesquioxane (acryl-POSS) and a perfluorous monomer (2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptyl acrylate) in UV-transparent fused-silica capillaries within 5 min. The physical characterization of hybrid fluorous monolith, including scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, mercury intrusion porosimetry (MIP) and nitrogen adsorption/desorption measurement was performed. Chromatographic performance was also evaluated by capillary liquid chromatography (cLC). Due to the fluorous–fluorous interaction between fluorous monolith and analytes, fluorobenzenes could well be separated, and the column efficiencies reached 86,600–92,500 plates/m at the velocity of 0.87 mm/s for alkylbenzenes and 51,900–76,000 plates/m at the velocity of 1.10 mm/s for fluorobenzenes. Meanwhile, an approach to integrate nanoelectrospray ionization (ESI) emitter with hybrid fluorous monolithic column was developed for quantitative determination of perfluoroalkyl acids by nanoHPLC–ESI-MS/MS. The integration design could minimize extracolumn volume, thus excluding undesirable peak broadening and improving separation performance.
研究领域:
分析化学
·
环境科学
·
质谱分析
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF MASS SPECTROMETRY
·
2012
·
IF 1.207
Changjuan Guo,Wei Gao,Zhengxu Huang,Hui Zhu,Zhong Fu,Junguo Dong,Ping Cheng,Zhen Zhou
We have described a home-made desktop orthogonal-injection time-of-flight (O-ToF) mass spectrometer combining a collisional cooling system. This O-ToF consists of a simple electrospray ion source, an atmosphere–vacuum interface, an area of transmission, including a radio-frequency only quadrupole (RF-only quadrupole, RFQ) as a collisional cooling cell and an orthogonal ToF mass analyzer. In order to detect ions of small m/z value, such as small metal ions, the RFQ has been improved to weaken the mass discrimination effect against low mass ions. Metal salt solutions were used in the experiment. The system has shown a satisfactory resolving power in the spectra (m/Am = 3500), a good mass stability, a limit of detection of 80 fg and a mass accuracy of 48 ppm. The dynamic range is found to be from 10−8 mol L−1 to 10−5 mol L−1, allowing the semi-quantitative analysis of metal ions.
研究领域:
分析化学
·
质谱技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CONTROL
·
2025
·
IF 6.3
Zhengchao Shen,Xiuli Xu,Xiujuan Wang,Zhenxia Du,Tong Liu,Feng Zhang
Macrolides are widely-used antibiotics that have raised continuous concerns due to their potential toxicity to humans. Determination of macrolides in complex food matrices by ambient mass spectrometry (AMS) remains a challenge because the lack of selectivity of AMS ion source. Herein, we proposed a novel boronic acid-functionalized covalent organic frameworks coated steel sheet (SSS@COF@BA) serving both as an extraction substrate and an AMS ion source for macrolide determination. The boronic groups on SSS@COF@BA surface can specifically capture the macrolides containing cis-diols via boronate affinity and thereby greatly enhance the extraction selectivity. The adsorption studies revealed that SSS@COF@BA exhibited high selectivity with enrichment factors of 62.26-191.11 compared to bare SSS and satisfactory recoveries for macrolide extraction (>80%) in the presence of interfering antibiotics, large adsorption capacities (6.18-28.58 μg/piece), and good reusability (≥six cycles). The SSS@COF@BA after extraction process was directly subjected to high voltages for electrospray ionization mass spectrometry (ESI-MS) detection. The proposed SSS@COF@BA-ESI-MS method was validated, and proven to be rapid (analysis time < 1 min), sensitive (limits of detection: 0.01-0.09 μg/kg) and accurate (recoveries: 81.84-110.23%) for trace macrolide determination in milk. Overall, this study introduces an efficient approach for the rapid detection of trace food contaminants by the self-developed selective AMS ion source.
研究领域:
分析化学
·
质谱学
·
食品安全
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Su-zhen Zhu,Li Zhang,Jing Zhang,Yin-long Guo
Fingerprinting mass spectrometric analysis at atmospheric conditions has been realized using an arc plasma-based dissociation (APD) device. Because of its high energy, high temperature, and unique chemical reactivity, the thermal plasma can induce dissociation of neutral molecules or ions produced by atmospheric ion sources. Both even/odd electron (fragment) ions would be generated to provide fingerprinting structural information and molecular weight of the compounds simultaneously. Meanwhile, elimination and aromatization were observed as special dissociation patterns in this device, which can be applied in the differentiation of isomers. The good compatibility with atmospheric ion sources is demonstrated by coupling the device with nanoelectrospray ionization (nano-ESI) and zero volt paper spray ionization (PSI), respectively. With erythromycin as the tuning standard, informative dissociation spectra of various compounds can be reproducible, making it possible to establish an arc plasma-based dissociation spectra database. This device allows fingerprinting mass spectrometric analysis, with no need for harsh vacuum conditions and is promising for making a breakthrough in making up the deficiency of atmospheric ionization techniques.
研究领域:
分析化学
·
质谱学
·
等离子体科学
·
大气离子化技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）