ACS Biomaterials Science & Engineering
·
2023
·
IF 5.8
Ying Zhou,Min Tian,Ruichun Li,Yan Zhang,Guomei Zhang,Caihong Zhang,Shaomin Shuang
An electrochemical sensor applied for dopamine (DA) detection was constructed. An easy static way was used to synthesize bimetallic CoNi-MOF. Next, it was mixed with graphene oxide (GO) under ultrasound to get a uniform suspension. Subsequently, the solution was coated on the glassy carbon electrode (GCE) to form CoNi-MOF@ERGO/GCE by the electrochemical reduction method. The interaction between CoNi-MOF and electrochemically reduced graphene oxide (ERGO) enhances the electrocatalytic performance for DA detection. CoNi-MOF@ERGO/GCE has a wider linear range (0.1–400 μM) and a lower detection limit (0.086 μM) under optimum conditions. Furthermore, it has been applied to test DA in human serum samples. The results reveal that the DA sensor shows excellent performance, which will provide a novel idea for more sensitive and quicker DA detection.
研究领域:
生物化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2023
·
IF 4.3
Liang Zhang,Junhui Xu,Jing Qian,Yazhen Wang
Neohesperidin dihydrochalcone (NHDC), as a high-intensity sweetener, has been widely used to be a new food additive . In this study, zeolitic imidazolate framework (ZIF)− 8/electrochemical reduced graphene oxide (ErGO) composite materials were favorably constructed onto the glassy carbon electrode (GCE) by two simple steps without any dispersant , and an electrochemical sensing of NHDC was developed. The morphology and its structure of the composite materials were characterized by SEM and Raman. The two-electron two-step redox mechanism was investigated by cyclic voltammetry (CV). The first anodic peak current of NHDC at ZIF-8/ErGO electrode is about 3.8 times as much as that of ErGO GCE and 42 times of ZIF-8 GCE under the optimized conditions. The linear relationship between oxidation peak current of NHDC and its concentration is ranged from 0.08 to 80 μM by linear sweep voltammetry (LSV), with the detection limit of 31.5 nM (based on S/N = 3). Finally, the modified electrode was used to detect NHDC in milk samples with a recovery rate of 98.3∼106.3%, which implied its feasibility for the determination of NHDC in actual samples.
研究领域:
食品科学
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材料科学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CONTROL
·
2019
·
IF 4.248
Baoshan He,Dandan Yan
In this work, an electrode which comprises Au nanoparticles (AuNPs) and electrochemically reduced graphene oxide (ERGO) recombined Cu based metal-organic framework (Cu-TDPAT) was prepared for nitrite detection. The structure and constituent of the modified material were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD) and FT-IR. The electrochemical behavior of nitrite at the modified electrode was performed by cyclic voltammetry and electrochemical impedance spectroscopy. The results indicated that the oxidation process of nitrite happened at recommended electrode had a superior response. The proposed electrode showed high electrocatalytic capacity toward nitrite oxidation with a wide linear working range (0.001–1000 μmol·L −1 ) and a detection limit of 0.006 μmol·L −1 . Finally, the sensor was successfully applied to detect nitrite in real sample and achieved desirable recovery rate, showing its potential application in real-time detection of food .
研究领域:
分析化学
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材料科学
·
食品科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2023
·
IF 4.5
Yong Xu,Zhengjie Zhang,Yurong Wang
A sensitive electrochemical sensor composed of electrochemically reduced graphene oxide (ErGO) and glassy carbon electrode (GCE) was developed to detect fangchinoline (FAN) selectively. The electrochemical behavior of FAN at the ErGO/GCE was studied by cyclic voltammetry. The electroanalytical method for FAN detection was established using linear sweep voltammetry. Under optimized experimental conditions, the detection limit of 17 nM (S/N = 3) and a linear calibration range of 0.05 to 10 μM were obtained. The reproducibility and repeatability of the method were calculated to be 2.6 % and 4.7 %, respectively. The sensor showed good stability during seven weeks and good selectivity for FAN. It was successfully applied to detect FAN in urine and serum with a good recovery from 97.3 % to 109 % with tetrandrine (TET) and 93.0 % to 106 % without TET.
研究领域:
电化学
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分析化学
·
生物传感器
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2018
·Vol. 10
·期 27
·3380-3385
·
IF 2.073
Xionghui Ma,Jianping Li,Jinhui Luo,Chunhua Liu,Shuhuai Li
A three-dimensional Cu2O/electrochemically reduced graphene (ErGO)-modified electrode was developed for the determination of dimetridazole. Cu2O/GO was initially prepared using a modified solvothermal method, and the 3D structure was constructed by electrodepositing a Cu2O/GO dispersion on a glassy carbon electrode in the presence of lithium perchlorate. The enhanced electrocatalytic reduction of dimetridazole was confirmed, and the electrochemical reduction reaction was found to be a typical adsorption-controlled process. Our results revealed that the response to dimetridazole was linear in the concentration range of 30–150 nmol L−1 and the detection limit was 3.64 nmol L−1. The prepared electrode was also employed to detect dimetridazole in an egg sample, thereby indicating its potential practical application.
研究领域:
分析化学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Hao Zhou,Qing Lu
In this work, a facial electrochemical method was developed for the sensitive triclosan (TCS) detection. The Au nanoparticles-electrochemically reduced graphene oxide (Au-ErGO) composite was deposited on glassy carbon electrode (GCE) by electrochemical way. Dodecanethiol (DDT) monolayers further self-assembled on Au-ErGO by forming Au-S bond. SEM, AFM, EDS, Raman, contact angle test and electrochemical way were applied to characterize the composites. The wrinkled Au-ErGO film would provide more active sites for TCS oxidation. More importantly, DDT monolayers could reduce the non-faradic current derived from the electrolyte. Therefore, the electrochemical response of TCS was effectively amplified on DDT/Au-ErGO/GCE with low background current. Under optimal conditions, the linear response of TCS on the modified electrodes ranged from 0.500 nM to 20.0 µM. The detection limit was calculated to be 0.253 nM. The modified electrode presented a reliable, sensitive and selective determination of TCS. Moreover, the sensor exhibited favorable analytical performance in lake water and daily chemicals.
研究领域:
分析化学
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环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2018
·
IF 8.173
M.Z.H. Khan,Xiaoqiang Liu,J. Zhu,F. Ma,W. Hu,Xiuhua Liu
This work reports the development of a simple and cost-effective electrochemical sensor based on electrochemically reduced graphene oxide (ErGO) bound to the surface of indium tin oxide (ITO) electrode through 3-aminopropyltriethoxysilane (APTES) monolayer (ITO/APTES/ErGO) for selective and sensitive detection of tyramine . The features of the modified electrode were studied by scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance (EIS) methods. The analytical performance of the developed sensor was evaluated with respect to linear detection range, limit of detection, stability, coexistence interference and reproducibility. The modified device exhibited electrocatalytic activity toward tyramine oxidation within two linear concentration range of 1–100 nM, and 1–100 µM, with LOD of 0.1 nM. Finally, the sensor successfully detected tyramine in commercially available real samples with satisfactory recovery ranges. The proposed modified sensor offers distinct advantages including low cost, simple handling, good sensitivity and high selectivity.
研究领域:
分析化学
·
生物医学工程
·
电化学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2018
·Vol. 165
·期 16
·B893
·
IF 3.662
Jingfang Hu,Ye Liu,Guowei Gao,Xiaoping Zou
One-step electrochemical approach for synthesis of AuPdNPs/ERGO nanocomposite has been developed for Cr(VI) sensing in water. The bimetallic AuPd nanoparticles and electrochemical reduced graphene oxide (ERGO) composite (AuPdNPs/ERGO) were reduced from H2PdCl4, HAuCl4 and GO mixed solution and deposited onto glass carbon electrode (GCE) through cyclic voltammetry, simultaneously. The bimetallic AuPdNPs were homogeneously modified on graphene nanosheets and characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDX) technique. Based on the voltammetric results, the bimetallic AuPdNPs/ERGO/GCE had higher catalytic activity for Cr(VI) determination, compared with AuNPs/GCE, PdNPs/GCE and ERGO/GCE obtained by the same method. The fabricated AuPdNPs/ERGO/GCE shows good relationship in two concentration ranges from 0.05 μM to 5 μM and 5 μM to 1000 μM, with a detection of 0.013 μM (at S/N = 3). In addition, the proposed modified electrode presents high selectivity, sensitivity and stability for Cr(VI) detection and a high recovery of more than 95% was obtained towards real water application, which makes it favorable for the further practical field monitoring.
研究领域:
材料科学
·
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Min Zhao,Wenhao Shao,Jing Zhang,Yujie Xiao,Mingyang Xu,Chenmin Liu,Fanru Zhong,Xuehong Li,Min He,Lang Zhao,Xia Cui,Pengqi Guo
The usage of antineoplastic drugs and immunosuppressants, represented by methotrexate (MTX), has been increasing. However, their administration is characterized by significant inter-individual variability, often leading to ineffective treatment or severe adverse reactions, necessitating therapeutic drug monitoring (TDM). This study proposes a fabrication strategy for an electrochemical sensor, involving the electroreduction of graphene oxide (GO) followed by the deposition of zirconium dioxide nanoparticles (ZrO 2 NPs) to construct a ZrO 2 -decorated electrochemically reduced graphene oxide-modified glassy carbon electrode (ZrO 2 -ERGO/GCE). The developed electrochemical sensor was employed to detect MTX in phosphate-buffered saline (PBS) and diluted calf serum simulated samples. The ZrO 2 -ERGO/GCE sensor exhibited two segments of good linearity within a wide concentration range of 1 μmol/L - 600 μmol/L (with R 2 values of 0.9954 and 0.9936, respectively)， with a sensitivity of 7.09 μA/(μM·cm 2 ) and a low detection limit of 7.72 nmol/L. The platform achieved high sensitivity, a low detection limit, wide linear range, excellent reproducibility, long-term stability, and robust anti-interference capability against common biological species, demonstrating its promising potential for clinical TDM applications.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2021
·Vol. 25
·期 4
·1383-1391
·
IF 2.647
Yang Hongmei,Hu Peiyu,Tang Jing,Cheng Ying,Wang Fang,Chen Zilin
A simple and sensitive bifunctional electrochemical aptasensor for detection of adenosine and thrombin has been developed using gold nanoparticles–electrochemically reduced graphene oxide (AuNPs-ERGO) composite film-modified electrode. Firstly, the reduced graphene oxide film and AuNPs were sequentially immobilized on glassy carbon electrode (GCE) surface. Secondly, thrombin aptamer was immobilized on the modified electrode. Finally, adenosine aptamer was hybridized with it to serve as a recognition element and methylene blue (MB) as electrochemical signal indicator. In the presence of adenosine or thrombin, the sensor recognized it and a conformational change was induced in aptamer, resulting in decrease of the peak current of MB. The linear relation between concentration of adenosine or thrombin and peak current of MB allowed quantification of them. Thanks to the special electronic characteristic of AuNPs-ERGO composite film, sensitivity of sensor was greatly improved. Under optimal conditions, the proposed aptasensor presented an excellent performance in a linear range of 25 nM to 750 nM for adenosine and 0.5 nM to 10 nM for thrombin. Detection limits were estimated to be 8.3 nM for adenosine and 0.17 nM for thrombin, respectively. Moreover, dual-analyte detection of adenosine and thrombin was achieved without potentially increasing the complexity and cost of the assay.
研究领域:
分析化学
·
生物传感器
·
纳米技术
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2018
·
IF 8.173
Cong Li,Ruijun Wu,Juncheng Zou,Tingting Zhang,Sufang Zhang,Zhiquan Zhang,Xin Hu,Youqi Yan,Xiaomei Ling
Herein, the ternary composites, ultrasmall metal nanoparticles encapsulated in the anionic metal-organic frameworks/electrochemically reduced graphene oxide (MNPs@Y-1, 4-NDC-MOF/ERGO, M = Ag, Cu) are constructed by a cationic exchange strategy and an electrochemical reduction process for the electrochemical determination of H 2 O 2 . Both AgNPs@Y-1, 4-NDC-MOF/ERGO and CuNPs@Y-1, 4-NDC-MOF/ERGO display excellent electrocatalytic activity toward H 2 O 2 , but the former is superior to the latter. Such a difference in electrocatalytic activity can be explained by the characterization measurements, and the results manifest MNPs@Y-1, 4-NDC-MOF/ERGO (M = Ag, Cu) electrocatalysts have subequal MNPs sizes and electrochemical surface areas, but different electron transfer rate constants. The AgNPs@Y-1, 4-NDC-MOF/ERGO sensor shows a linear detection range from 4 to 11,000 μM with the detection limit of 0.18 μM. Moreover, MNPs@Y-1, 4-NDC-MOF/ERGO (M = Ag, Cu) exhibit excellent anti-interference performance and can be used for the detection of H 2 O 2 released from living cells. The proposed sensor takes full advantage of the catalytic property of MNPs, the size selectivity of Y-1, 4-NDC-MOF, and the fast electron transport effect of ERGO. Thus, the MNPs@Y-1, 4-NDC-MOF/ERGO/GCE (M = Ag, Cu) can be utilized to detect oxidase activities by monitoring H 2 O 2 produced in the presence of substrate and oxidase, and it is expected that composites with the molecular sieving effect and catalytic activity can be widely applied for catalysis, biomedicine , and biosensing fields.
研究领域:
生物传感
·
电化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sensors
·
2024
·
IF 8.2
Jiatao Chen,Fuyun Xia,Xiuting Ding,Dongdong Zhang
Highly selective and sensitive in vivo neurotransmitter dynamic monitoring of the central nervous system has long been a challenging endeavor. Here, an implantable and biocompatible microsensor with excellent performances was reported by electrodepositing poly(3,4-ethylenedioxythiophene)-electrochemically reduced graphene oxide (PEDOT-ERGO) nanocomposites and poly(tannic acid) (pTA) sequentially on the carbon fiber electrode (CFE) surface, and its feasibility in in vivo electrochemical sensing applications were demonstrated. Due to the synergistic electrocatalytic effect of PEDOT-ERGO nanocomposites with the negative-charged pTA on dopamine (DA) redox reaction, the microsensor exhibits high detection sensitivities of 1.1 and 0.37 nA μM–1 in the detection ranges of 0.02–0.5 and 0.5–20 μM with a low limit of detection of 9.2 nM. Also, the microsensor shows excellent selectivity, good sensing stability, repeatability, and reproducibility. In addition, the highly hydrophilic and negative-charged pTA inhibits the nonspecific adsorption of hydrophobic proteins, which endows the microsensor with good antifouling ability. Moreover, DA dynamics in rat brain were successfully monitored in real time, and the selective sensing ability of the microsensor in vivo was also demonstrated. The present study provides a new method for selective dynamics monitoring of DA in the brain, which would help to better understand the pathological and physiological functions of DA.
研究领域:
神经科学
·
生物传感器
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）