SCIENCE OF THE TOTAL ENVIRONMENT
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2025
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IF 8
Wenju Zhu,Shuang Xu,Xiaokang Yang,Kai Song,Shuixia Liu,Shuolong Wang,Wei Peng,Zhao Dai,Chunlei Jiang
Phytic acid's high-efficiency flame retardant and N-halamine antibacterial were synergistically applied to cotton fibers for durable antibacterial and flame retardancy. Antimicrobial flame retardant structures were characterized by H Nuclear Magnetic Resonance Spectra (NMR) and Fourier Transform Infrared Spectrometer (FT-IR). FT-IR, X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscope (SEM), Thermogravimetric (TG), Vertical Flammability Test (VFT), and Limiting Oxygen Index (LOI) were utilized to test and characterize the prepared cotton fibers. The results showed that the antibacterial flame retardant could be durably grafted on the surface of cotton fibers for a long time, and it still maintained its self-extinguishing property after 50 washing cycles, with an LOI value of 32.2 % and a damaged length of 67 mm. The N Cl bond was formed by simple bleaching treatment, which exhibited excellent bacteriostatic effect, and had a significant inhibitory effect on Escherichia coli and Staphylococcus aureus , and chlorine oxide, as an antibacterial factor, could be reactivated after long-term storage and washing. Through the systematic analysis of cone calorimetry and carbon residue, it was concluded that the flame retardant mechanism of antibacterial flame retardant was mainly condensed phase. The results of the physical property analysis of cotton fibers showed that the whiteness, air permeability, flexibility, and other physical properties of cotton fibers had no obvious change, while the hydrophilicity of the finished fibers were enhanced.
研究领域:
材料科学
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纺织工程
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生物学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jie Li,Maoli Yin,Xi Wang,Lei Chen,Yangfeng Wang,Wei Li,Xun Zhang,Zhenzhen Xu,Xiaojuan Li
To address the clinical challenge of wound infection and secondary injury caused by frequent dressing changes during wound healing, this study aims to develop a chitosan-based aerogel dressing with on-demand dissoluble and efficient antibacterial functionality. A low-temperature alkaline urea dissolution strategy enabled the fabrication of chitosan aerogels (CS) through thermally induced gelation, solvent exchange, and freeze-drying. Subsequent ultrasonic-assisted adsorption of N-halamine 1,3-dichloro-5,5-dimethylhydantoin (MC) yielded functionalized N-halamine-loaded chitosan aerogels (CS-MC). Systematic optimization established 2.0 % CS (based on apparent density, porosity, and ethanol adsorption) and 1.5 % MC loading (determined via swelling kinetics, chlorine release profiles, and antibacterial efficacy) as optimal parameters. 2.0 % CS-1.5 % MC had high effective antibacterial effect. The killing rates of E. coli and S. aureus were 78.57 % and 80.30 % at 1 min, respectively, and the killing rates of both bacterial reached 100 % within 5 min. CS-MC dressings were completely dissolved in a dilute acetic acid solution within 20 min. CS-MC aerogels maintain high fibroblast viability, above the 70 % defined by ISO 10993-5 cytotoxicity threshold, achieving an optimal balance between efficient bactericide and histocompatibility. In summary, CS-MC exhibit high antibacterial efficacy and on-demand dissoluble properties, making them suitable for medical dressings.
研究领域:
生物医学工程
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材料科学
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医学
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2015
·Vol. 132
·期 43
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IF 1.768
Xiaoqin Chen,Zuliang Liu,Weiwei Cao,Chunyan Yong,Xiaodong Xing
A viable method for coating of cellulose fiber with quaternarized N-halamine is reported in this article. The use of quaternary ammonium salt group in combination with N-halamine group can reinforce the antibacterial activity. The chemical structure of as-synthesized N-halamine precursor 4-(Bromo-acetic acid methylester)-4-ethyl-2- oxazolidinone (BEO) was characterized by 1 H-NMR. The cellulose fibers were characterized by Fourier transform infrared spectra and X-ray photoelectron spectra. The spectra data confirmed that the quaternarized N-halamine-grafted cellulose fibers were successfully obtained. The antibacterial properties of functional fibers were challenged with both Gram positive and Gram negative bacteria. The antibacterial tests and showed that the as-prepared antibacterial cellulose fibers exhibited powerful and rapid bactericidal performance against both Gram negative E. coli and Gram positive S. aureus . © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42702.
研究领域:
材料科学
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微生物学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
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2014
·Vol. 49
·期 9
·3391-3399
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IF 2.305
Jie Zhiqiang,Zhang Bing,Zhao Lianhong,Yan Xiufang,Liang Jie
A novel regenerable antimicrobial silica gel was prepared by a dehydration between silanols of silica gel and hydrolyzed 3-chloropropyltrimethoxysilane, a quaternization between grafted hydrolyzed 3-chloropropyltrimethoxysilane and (5,5-dimethylhydantoinyl-3-ylethyl)-dimethylamine (DHEDA), and a chlorination of amide groups of DHEDA. The as-prepared antimicrobial silica gel was characterized by FT-IR and X-ray photoelectron spectroscopy. Antimicrobial tests showed that the as-prepared antimicrobial silica gel was capable of about a 6-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 10 min of contact. Interestingly, more than 2 × 10 4 CFU/mL of Escherichia coli O157:H7 could be almost inactivated under flowing water condition. Furthermore, the as-prepared antimicrobial silica gel exhibits good regenerability and storage stability.
研究领域:
材料科学
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微生物学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Yingfeng Wang,Kaizhun Li,Wenjing Xue,Huang Hu,Ming Huang,Maoli Yin
Environmental contamination can cause serious problems in water cycling systems. In this study, mesoporous composite-supported N-halamines (MCSNs) were synthesized and characterized, where the surface area retention rate of the MCSNs was over 70 % higher than MCM-41. The reaction between organic N-halamines and formaldehyde was examined in aqueous phase. The monomeric N-halamines (MCDMH) rapidly reacted with formaldehyde (10 ppm, 10 mL), and finished completely within 10 min. The MCSNs only reacted with formaldehyde in the high molar ratio (Cl + to formaldehyde, 40:1) and alkaline conditions (pH higher than 10), and approximately 60 % of formaldehyde can be degraded within 10 min. The reaction kinetics were studied and the kinetic parameters were investigated. The MCSNs were highly effective against S. aureus (7.94 logs) and E. coli O157:H7 (8.0 logs) with 1 min of contact time, demonstrating impressive antibacterial properties in aqueous conditions. As a type of antibacterial material, MCSNs introduce a new direction for the application of N-halamine-based materials in formaldehyde decontamination , indicating their potential to be utilized as novel water treatment materials.
研究领域:
环境科学
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材料科学
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微生物学
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DOI
高影响因子
CARBOHYDRATE POLYMERS
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2025
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IF 12.5
Chenghao Li,Saren Gerile,Nan Du,Liang Zou,Zhiqiang Wang,Yanfang Liu,Jili Hou,Kuntong Song,Yuanhao Xiao,Hui Ren,Jing Kang,Alideertu Dong,Run Xu
Antibacterial hydrogels have attracted much attention in skin tissue engineering due to their superior ability to prevent infection. In this study, we developed an antibacterial hydrogel using a multi-active site N- halamine - modified dopamine-hyaluronic acid hydrogel. The in vitro antibacterial efficacy of the hydrogel exhibited 99.99 % against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus , while also demonstrating excellent biocompatibility. Furthermore, in Escherichia coli- infected skin wounds, the hydrogels effectively suppressed infection and significantly accelerated wound healing. These findings suggest that N -halamine-modified dopamine-hyaluronic acid antibacterial hydrogels have great potential as wound dressings for preventing infection and promoting the healing of infected wounds.
研究领域:
生物材料
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皮肤组织工程
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感染预防
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2019
·
IF 3.973
Yong Chen,Chunyan Feng,Qiang Zhang,Meimei Luo,Jingwen Xu,Qiuxia Han
A biocidal composite unit with improved synergism, using one cationic quaternary ammonia salt (QAS) site to attract electronegative bacteria to three highly biocidal N-halamine sites, was designed for the first time and attached onto surface of magnetic silica coated Fe 3 O 4 nanoparticles (silica@Fe 3 O 4 NPs) for superior biocidability, large killing area, and easy recyclability. Briefly, a compound containing one imide and two amide N H bonds, 2-(2,5-dioxoimidazolidin-4-yl)-N-(4-hydroxyphenyl)acetamide (DHPA), was prepared by amidation of hydantoin acetic acid with p-aminophenol. A biocidal precursor of one QAS site and three N-halamine sites was then constructed by alcoholysis of 3-triethoxysilylpropyl succinic anhydride with 2-(dimethylamino)ethan-1-ol to introduce a tertiary amine and subsequent esterification with DHPA to introduce three N H bonds. The triethoxysilyl groups in the precursor were hydrolyzed to silanol groups to condense with their counterparts on silica@Fe 3 O 4 NPs. The surface of resultant NPs carried units each contains one QAS site and three N-halamine sites after quaternization and chlorination. The biocidal surface showed superior biocidability against Escherichia coli and Staphylococcus aureus than reported systems due to the improved synergism between multiple antibacterial groups of different types and was stable towards quenching-chlorinating process and storage. The successful design opens insight in the syntheses of more powerful biocides.
研究领域:
材料科学
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生物学
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化学工程
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DOI
PubMed
高影响因子
Materials Research Express
·
2020
·Vol. 7
·期 5
·055307
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IF 1.929
Xiaomei Liang,Xin Chen,Jianli Zhu,Lixian Liu,Wei Wang,Xu Wang,Chunsheng Qu
Macromolecules incorporating N-halamines have shown significant antibacterial properties and can be regenerated by chlorination. In this work, a new type of regenerable material made of nano-sized latex particles having N-H groups was prepared via the emulsion polymerization of methacrylamide and dodecafluoroheptyl methacrylate with divinylbenzene as a crosslinker. The N-H moieties in this polymer were subsequently transformed into N-Cl groups by chlorination with an aqueous sodium hypochlorite solution, and films were prepared by casting on substrates previously coated with a self-adhesive silicone rubber. The nanoparticles and the films were characterized by Fourier transform infrared (FTIR) spectroscopy, x-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), contact angle measurements, scanning electron microscopy (SEM) and microbiological tests. The results showed that F and Cl were successfully incorporated in the nanoparticles, that the films were thermally stable and hydrophobic (with a contact angle of 152°), and that these materials exhibited antimicrobial properties. The N-Cl groups killed bacteria by releasing active chlorine as they transitioned to N-H groups, and could be re-chlorinated with a methanol solution of isocyanuric chloride. FTIR and XPS analyses confirmed this regeneration, while SEM image showed that the morphology of the original microspheres was maintained after re-chlorination. The re-chlorinated films also maintained superhydrophobic and bactericidal characteristics.
研究领域:
材料科学
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生物学
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DOI
高影响因子
CELLULOSE
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2019
·Vol. 26
·期 9
·5621-5633
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IF 3.917
Zhang Shengli,Kai Chengcheng,Liu Bofang,Zhang Silue,Wei Wei,Xu Xiaoling,Zhou Zuowan
Abstract Polyethylenimine (PEI), a type of water-soluble chain polymer containing a great number of primary, secondary and tertiary amine groups in the molecule, was used as an N-halamine precursor. It was grafted onto dialdehyde cellulose membrane (DCM) followed by chlorination to prepare a novel N-halamine antibacterial cellulose membrane (Cl–PEI–DCM). The appropriate conditions affecting the aldehyde content of DCM and the active chlorine (Cl + ) content of Cl–PEI–DCM were systematically studied at oxidation, grafting and chlorination stages, respectively. The structure and properties of the samples were investigated by SEM, ATR–FTIR, XRD, XPS, light transmittance measurements and tensile tests. The stability and rechargeability of the Cl–PEI–DCM were evaluated, and its antibacterial activity was tested against S. aureus and E. coli . Results showed that the Cl + content of the chlorinated samples was strongly dependent on the aldehyde content of DCM and PEI concentration. Under the optimum testing condition, the Cl + content of the Cl–PEI–DCM reached 1.30 wt%. The hydroxyl groups on the cellulose membrane were changed to aldehyde groups and the successful introduction of PEI and N–Cl bond were confirmed. The 1.30 wt% Cl–PEI–DCM exhibited high antibacterial activity against both S. aureus and E. coli , which can completely inactivate two bacterial pathogens within 5 min even after 15 days of storage. Moreover, the Cl–PEI–DCM membrane displayed good stability, rechargeability, transparency and high mechanical strength. These results demonstrated that the Cl–PEI–DCM can be considered as a visualized wound dressing material or antibacterial shoe insole. Graphical abstract
研究领域:
材料科学
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生物学
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医学
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DOI
高影响因子
RSC Advances
·
2013
·Vol. 4
·期 12
·6048-6054
·
IF 2.562
Zhiqiang Jie,Xiufang Yan,Lianhong Zhao,Shelby Davis Worley,Jie Liang
An effective macroporous cross-linked antimicrobial polymeric resin containing N-halamine and quaternary ammonium salt moieties was synthesized in an eco-friendly and economical way. Commercially available macroporous crosslinked chloromethylated polystyrene (CMPS) resin reacted with the salt of 5,5-dimethylhydantoin (DMH) and trimethylamine (TMA) in water to produce a polymeric resin containing hydantoinyl and quaternary ammonium salt moieties, poly(p-methylstyrene)-3-(5,5-dimethylhydantoin)-co-trimethyl ammonium chloride (PSHTMA). The hydantoinyl groups in PSHTMA were converted to an antimicrobial N-halamine structure by a facile chlorination reaction in dilute NaOCl solution. The as-synthesized antimicrobial polymeric resin (Cl-PSHTMA) was characterized by FT-IR, X-ray photoelectron spectroscopy, and zeta-potential measurement. The antimicrobial tests showed that the as-synthesized antimicrobial polymeric resin was capable of 7-log inactivation of S. aureus and 8-log inactivation of E. coli within 1 minute contact time. Moreover, the N-halamine moieties in Cl-PSHTMA exhibited excellent regenerability.
研究领域:
材料科学
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微生物学
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环境科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Lifan Li,Deming Zhou,Jiapeng Ye,Kun Luan,Zaixing Zhang,Lingxiao Jing,Tonghua Zhang
Long-lasting antibacterial properties in cotton fabric address microbial growth, odor formation, and hygiene issues, which are common drawbacks at the usage of natural fibers. Recent cotton market demands durable, eco-friendly solutions that enhance fabric longevity and performance in various applications. This study presents the development of a durable and multifunctional antibacterial cotton fabric achieved through a feasible and cost-effective “one-bath” impregnation process. A N -halamine precursor, featuring a terminal chlorine group (TD@Cl), was chemically bonded to the hydroxyl groups of cotton fabric, imparting enhanced antibacterial properties along with flame-retardancy, hydrophobicity, and self-cleaning capabilities. The TD@Cl treated fabric, designated as COTD, demonstrated exceptional antibacterial efficacy, exhibiting over 99.99% efficacy against both S. aureus and E. coli , with rapid bactericidal action within 3 min of contact. Notably, the COTD-Cl fabric maintained its antibacterial performance even after 40 washing cycles. Flame-retardancy tests revealed a 43.4% reduction in total heat release (THR) compared to untreated cotton. The fabric exhibited superior hydrophobicity and self-cleaning properties. Its air permeability and water vapour permeability are also discussed. These results highlight the potential of this efficient method to produce durable, multifunctional cotton fabrics suitable for a wide range of practical usages, such like garments, decoration and furniture etc.
研究领域:
材料科学
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纺织工程
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微生物学
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2021
·
IF 3.171
Qinggele Borjihan,Quanfu Yao,Huihui Qu,Haixia Wu,Ying Liu,Alideertu Dong
Antibiotic-resistant bacteria contamination in environments imposes great threats to human life health. This research aims to develop novel targeted antibacterial biochars for achieving high selectivity to kill pathogenic Escherichia coli ( E. coli ). The glycopolymer N -halamine-modified biochars ( i.e ., BCPMA-Cl) were synthesized by the modification of biochars with poly[2-(methacrylamido) glucopyranose- co -acrylamide] (P(MAG- co -AM), followed by chlorination treatment. Based on the results of FTIR, turbidity, XPS, and UV–vis, BCPMA-Cl was successfully synthesized and demonstrated to be able to eliminate Staphylococcus aureus ( S. aureus ) and E. coli. Especially, BCPMA-Cl possessed extremely potent to specific-killing 10 4 CFU∙ml −1 of E. coli with lower hemolytic activity (<5%). Additionally, the antibacterial mechanisms of BCPMA-Cl against bacteria were contact-killing and release-killing contributed by active chlorine ( i.e ., Cl + ). Therefore, this work provided a cost-effective and facile approach for preparation of functional biochars used for bacteria-specific therapeutic applications via livestock pollutants as well as showing a promising strategy to avoid bacterial resistance.
研究领域:
环境科学
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微生物学
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材料科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）