MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 3
·1-11
·
IF 5.3
Liu Huamin,Li Chenghong,Wang Lina,Fang Lichao,Huang Hui,Deng Jun,Hu Yue,Li Mimi,Ran Xiaoping,Li Lulu,Zheng Junsong
A “signal-off” photoelectrochemical (PEC) sensing platform has been designed for the ultrasensitive detection of DNA methylation levels and multiple methylated sites. The platform employs tungsten trioxide and TpPa-1-COF loaded by gold nanoparticle (AuNPs@WO 3 @TpPa-1-COF) composite material as the photoactive component and p-type reduced graphene (rGO) as an efficient quencher. The PEC signal of AuNPs@WO 3 @TpPa-1-COF composite is effectively quenched in the presence of p-type rGO, because p-type rGO can compete with AuNPs@WO 3 @TpPa-1-COF to deplete light energy and electron donors. In addition, a hybrid strand reaction (HCR) amplification strategy fixes more target DNA and then combines with rGO-modified anti-5-methylcytosine antibody to facilitate ultrasensitive DNA methylation detection. Under optimal conditions, DNA methylation can be measured within a linear concentration range of 10 –14 to 10 –8 M, with an exceptionally low detection limit of 0.19 fM (S/N = 3). At the same time, the platform can conduct quantitative determination of multi-site methylation, with the linear equation △I = 44.19Log A + 61.43, and the maximum number of methylation sites is 5. The sensor demonstrates high sensitivity, excellent selectivity, and satisfactory stability. Furthermore, the proposed signal-off PEC strategy was successfully employed to detect DNA methylation in spiked human serum samples, with recoveries ranging from 93.17 to 107.28% and relative standard deviation (RSD) ranging from 1.15 to 5.49%. Graphical
研究领域:
生物化学
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分析化学
·
材料科学
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2022
·
IF 10.319
Long Sun,Lingling Li,Jiajie Fan,Quanlong Xu,Dekun Ma
The rapid charge recombination and low surface reaction kinetics are the two major constraints to the photocatalytic performance of covalent organic frameworks (COFs). To accelerate the charge separation behavior, TpPa-1-COF is decorated with WO 3 via an in-situ growth approach, and the resultant WO 3 /TpPa-1-COF composites show significantly improved photocatalytic performance. Especially, when the WO 3 loading arrives at 3 wt%, 3%WO 3 /TpPa-1-COF exhibits the maximum photocatalytic H 2 evolution rate of 19.89 mmol g −1 h −1 , which is approximately 4.8 times higher than that of pure TpPa-1-COF. The apparent quantum efficiency (AQE) of 3%WO 3 /TpPa-1-COF at 420 nm is detected to be 12.4%. X-ray photoelectron spectroscopy (XPS) characterization confirms the formation of internal electric field between WO 3 and TpPa-1-CF, which can drive the photogenerated charge carrier diffusion in S-scheme mode. As a result, WO 3 /TpPa-1-COF composite possesses high charge separation efficiency and strong redox ability, which is further supported by the photoelectrochemical results, thus benefiting the photocatalysis process. This work provides a rational strategy to modify COFs in photocatalytic water splitting.
研究领域:
材料科学
·
光催化
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Jiating Zheng,Shuyao Huang,Yuanjun Tong,Songbo Wei,Guosheng Chen,Siming Huang,Gangfeng Ouyang
The secretion disorder of sex hormones is the source that leads to the occurrence of many diseases such as polycystic ovarian syndrome (PCOS), hyperandrogenism and so on. There exist physiological changes in human body when slight fluctuations in concentrations of sex hormones happen. Therefore, it’s of great significance for accurate detection of sex hormones in human body. In this work, TpPa-1 COF solid-phase microextraction (SPME) fiber was prepared using high-efficient in-situ synthesis strategy and coupled with HPLC-MS/MS to detect three sex hormones, including Progesterone (P), testosterone (T) and dehydroepiandrosterone (DHEA) in human serum. The thickness of the coating reached 7 μ m within 2 h. Under the optimal conditions, the established method presented low limit of detections (LODs, ≤ 0.75 ng/mL), wide linear ranges (0.100–100 ng mL −1 ) and good reproducibility, and three sex hormones (T, P, DHEA) were successfully detected and quantified in human serum. In conclusion, the established SPME method presented high-efficient fiber preparation and good analytical performances of sex hormone detection, therefore was in great potential for application in clinical.
研究领域:
分析化学
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医学检测
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Tianzhan Zhang,Yurou Wang,Rongrong Yuan,Yanfei Qi
A chemically stable crystalline covalent organic framework (TpPa-1-COF) was successfully synthesized using simple mechanical ball milling method. Owing to its hydrophobic interaction, hierarchical pores, extended π-conjugation skeleton and excellent stability, the TpPa-1-COF can efficiently immobilize aptamer to fabricate an electrochemical sensor for detection of Staphylococcus aureus ( S. aureus ), achieving a low limit of detection of 0.28 CFU⋅mL -1 (3σ/S). Furthermore, the TpPa-1-COF-based electrochemical aptasensor exhibited good stability, excellent reproducibility and high selectivity. Notably, the TpPa-1-COF-based electrochemical aptasensor can quantitatively detect S. aureus in spike samples, demonstrating its potential contribution to food safety assurance.
研究领域:
生物化学
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分析化学
·
微生物学
✓ 已验证
DOI
高影响因子
DESALINATION
·
2025
·
IF 9.8
J.Y. Chen,X.N. Ren,X.W. Gao,Z.X. Yang,G.G. Cheng,X.H. Hu,D.T. Bui
The development of next-generation desiccant materials is essential for achieving energy-efficient atmospheric water harvesting and air dehumidification under hot and humid conditions. Conventional desiccants such as silica gel and zeolites are limited by high regeneration temperatures, low water uptake, or poor hydrothermal stability, while salt-based sorbents suffer from deliquescence and leakage. To address these challenges, this study presents a LiCl@TpPa-1 covalent organic framework (COF) composite that integrates the structural robustness of TpPa-1 with the hygroscopic functionality of lithium chloride. Structural and thermodynamic analyses confirmed that LiCl incorporation enhances water affinity without compromising crystallinity or stability, enabling low-temperature regeneration below 70 °C. The composite was successfully coated onto aluminum heat exchanger fins using an optimized polymeric binder, yielding a uniform, durable sorption layer. System-level testing demonstrated a more than threefold improvement in moisture removal and a 2.5-fold increase in thermal coefficient of performance (COP) compared to silica gel under tropical conditions. This study goes beyond material-level characterization by bridging the gap between laboratory synthesis and practical application. The composite was successfully coated onto aluminum heat exchanger fins using an optimized polymeric binder, forming a uniform and durable sorption layer. System-level testing under realistic operating conditions demonstrated more than a threefold enhancement in moisture removal and a 2.5-fold increase in the thermal COP compared to silica gel under tropical climates. The material also exhibited excellent cyclic stability with negligible capacity loss after repeated dehumidification–regeneration cycles. These results highlight LiCl@TpPa-1 as a promising desiccant for sustainable, low-grade heat-driven dehumidification and water-harvesting technologies.
研究领域:
材料科学
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环境工程
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能源系统
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可持续技术
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吸附材料
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2026
·
IF 5.8
Saifei Du,Lei Ding,Shuqi Li,Kun Wang,Baojiang Liu,Wei Wang,Dan Yu,Chunyan Hu
MXene-based aerogels are promising for electromagnetic interference (EMI) shielding due to their lightweight nature and high conductivity. However, their practical application is often hindered by severe impedance mismatch and excessive secondary reflection. To overcome this limitation, we developed a multifunctional ternary composite aerogel (MTCA) via a synergistic self-assembly strategy. In this architecture, TpPa-1 covalent organic framework (COF) was grown in situ and integrated with MXene nanosheets within a chitosan matrix. The resulting hierarchical porous structure significantly optimizes impedance matching. Consequently, the optimized MTCA achieves an EMI shielding efficiency of 39.93 dB in the X-band, operating via an absorption-dominated mechanism. This performance stems from enhanced interfacial polarization at the MXene/COF heterojunctions and prolonged microwave propagation paths facilitated by multiple scattering within the porous network. Furthermore, the aerogel exhibits multispectral stealth capabilities: it demonstrates low infrared emissivity (ε = 0.50), superior thermal insulation (surface temperature of 28.7 °C under an 80 °C heat source), and effective visual camouflage adaptable to environmental backgrounds. This work presents a robust strategy for designing advanced stealth materials that integrate efficient absorption-dominant EMI shielding with multispectral compatibility.
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产品关联
DOI
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2023
·
IF 4
Zhang Xue-Feng,Chang Tian-Long,Guo Na,Jia Guo-Liang,Li Xiao-Bing,Zhao Zhao-Ye,Wang Hui,Wang Jun-Chuan,Wu Xiang-Feng,Pan Cheng-Si,Liu Lei,Yang Lin-Lin
Fe-based MOFs (Fe-MOFs) are excellent photocatalysts and have synergy well with Fenton reagents relative to other MOFs. In this work, a series of uniformly covered NH 2 -Fe-MIL-88B@TpPa-1-COF composites were synthesized using an in-situ anchoring growth strategy, which used F127 as functional molecule to decorate NH 2 -Fe-MIL-88B nanoparticles to eliminate their surface electrostatic repulsion with Tp molecules during the subsequent coating procedure. Meanwhile, the -NH 2 groups in the skeleton of NH 2 -Fe-MIL-88B could also be used as anchors to covalently connect TpPa-1-COF shell and migration channels for effective charge transfer. This uniformly covered core–shell structure would endow these composites with much more contact area and imine bond linkage between the Fe-MOFs core and COFs shell. Compared with the random packing structure, the uniformly covered Fe-MOF@COF-3 composite possessed a higher proportion of Fe 2+ to Fe 3+ . As a result, the optimized Fe-MOF@COF-3 catalyst could achieve the highest photo-Fenton degradation efficiency of 93.9% for tetracycline hydrochloride (TC⋅HCl), which was much higher than 54.8% of pure NH 2 -Fe-MIL-88B. In addition, the uniform TpPa-1-COF shell could further effectively enhance the stability of NH 2 -Fe-MIL-88B by protecting Fe ions from leaching, and the toxicity of the water samples treated with our photo-Fenton degradation process declined obviously. All these merits will endow Fe-MOF@COF-3 photo-Fenton catalyst great potential application value as in the field of environmental governance.
研究领域:
材料科学
·
环境科学
·
催化
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Mei-Ling Xu,Jia-Ran Li,Xiu-Mei Wu,Ting Yu,Guan-Ying Qin,Fu-Ji Wang,Li-Na Zhang,Kui Li,Xin Cheng
Covalent organic frameworks (COFs) as an emerging porous material have exhibited excellent application prospects in the field of photocatalysis. Nevertheless, the overall water splitting using solar energy by COF-based photocatalysts remains a huge challenge due to the rapid charge recombination and insufficient redox catalytic capacity. Herein, for the first time, the novel Fe-MOF-derived α-Fe 2 O 3 and FeP-PC was designed and adopted as dual co-catalysts to facilitate the separation and utilization efficiency of charge carriers and activate the overall water splitting performance of the ketoenamine based TpPa-1-COF, with both the porous α-Fe 2 O 3 and FeP-PC acting as the framework supporting to effectively prevent the agglomeration of TpPa-1-COF during the fabrication and photocatalytic process. Meanwhile, the construction of Z-scheme heterostructures and the connection of covalent bonds in the interface of α-Fe 2 O 3 /TpPa-1-COF/FeP-PC effectively facilitate the separation and transport of charge. Consequently, the optimal α-Fe 2 O 3 /TpPa-1-COF/FeP-PC excites very competitive photocatalytic overall water splitting performance.
研究领域:
材料科学
·
光催化技术
·
能源转换
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2022
·Vol. 18
·期 25
·2201340
·
IF 15.153
Ge Yan,Xiaodong Sun,Kailai Zhang,Yu Zhang,Hui Li,Yuhai Dou,Ding Yuan,Hongwei Huang,Baohua Jia,Hao Li,Tianyi Ma
2D covalent organic frameworks (COFs) are considered as one kind of the most promising crystalline porous materials for solar-driven hydrogen production. However, adding noble metal co-catalysts into the COFs-based photocatalytic system is always indispensable. Herein, through a simple solvothermal synthesis method, TpPa-1-COF, a typical 2D COF, which displays a wide light absorption region, is rationally combined with transition metal phosphides (TMPs) to fabricate three TMPs/TpPa-1-COF hybrid materials, named Ni 12 P 5 (Ni 2 P or CoP)/TpPa-1-COF. The incorporated TMPs can be served as electron collectors for accelerating the transfer of charges on TpPa-1-COF, thus the composites are demonstrated to be efficient photocatalysts for promoting water splitting. Benefitting from the richer surface reactive sites and lower H* formation energy barrier, the Ni 12 P 5 can most effectively improve the photocatalytic performance of the TpPa-1-COF, and the H 2 evolution rate can reach up to 31.6 µmol h −1 , approximately 19 times greater than pristine TpPa-1-COF (1.65 µmol h −1 ), and is comparable to the Pt/TpPa-1-COF (38.8 µmol h −1 ). This work is the first example of combining COFs with TMPs to construct efficient photocatalysts, which may offer new insight for constructing noble-metal-free COF-based photocatalysts.
研究领域:
材料科学
·
化学
·
能源科学
·
催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2023
·
IF 5
Zhipeng Zhao,Huimeng Feng,Dong Qin,Wen Li,Wei Wang,Shougang Chen
Herein, we designed and synthesized a two-dimensional covalent organic framework (2D-COF) of a Schiff base using a mechanical chemical grinding method. Moreover, capsaicin@chitosan (CAP@CS) microcapsules were loaded on a TpPa-1 COF by a physical adsorption method to prepare composites (CAP@CS/TpPa-1), which realized the pH-sensitive controlled release of the fungicide CAP, dispersed in fluorocarbon resin to prepare an intelligent coating with environmentally friendly long-term antifouling performance. TpPa-1 improves the antibacterial efficiency by increasing the dispersity of CAP@CS in the resin. Therefore, a CAP release amount of 2 wt % composite coating can meet the minimum bacteriostatic concentration of 37.5 μg/mL required for antifouling. Importantly, pH-responsive controlled release caused by the protonation of CS and the electrostatic interaction between CAP@CS and TpPa-1 COF and increased bacterial contact area by CAP@CS reunion inhibited by TpPa-1 COF improve the bactericidal efficiency of the composite. The composite coating has excellent corrosion resistance, mainly because COF extends the propagation path of the corrosive medium.
研究领域:
材料科学
·
化学
·
生物医学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）