基本描述

别名	FK-506一水合物 \| FK-506 一水合物 \| 他克莫司一水合物 \| 藤霉素一水合物
英文别名	D00107 \| Tacrolimus, Pharmaceutical Secondary Standard; Certified Reference Material \| TACROLIMUS [USP-RS] \| TACROLIMUS MONOHYDRATE [WHO-DD] \| FK 506 \| TACROLIMUS [ORANGE BOOK] \| TACROLIMUS MONOHYDRATE \| WM0HAQ4WNM \| FK-506 monohydrate, >=98% (HPLC) \| Pro
规格或纯度	≥80%(HPLC)
英文名称	Tacrolimus Monohydrate
生化机理	它是一种强效免疫抑制剂、神经保护剂和神经再生剂，也是体外 T 细胞增殖阻断剂。FK-506 可破坏 T 淋巴细胞中钙调素介导的信号转导，并与其 FK-506 结合蛋白-12（FKBP12）相互作用。
储存温度	避光,-20°C储存,充氩
运输条件	超低温冰袋运输
产品介绍	Tacrolimus monohydrate (FK506 monohydrate) 是大环内酯类化合物，Tacrolimus monohydrate 与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶 (calcineurin phosphatase)，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。 Application FK-506 monohydrate has been used: as an immunosuppressive agent in coculture medium to study the effect of immunologic reaction as a calcineurin inhibitor, in anhydrous Me2SO solution to treat retinal pigment epithelial cells to measure possible cytotoxicity

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504763414
分子类型	小分子
IUPAC Name	(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone;hydrate
INCHI	InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1
InChi Key	NWJQLQGQZSIBAF-MLAUYUEBSA-N
Canonical SMILES	CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC.O
Isomeric SMILES	C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC.O
WGK Germany	3
RTECS	KD4201200
分子量	822.03
Reaxy-Rn	43416939
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=43416939&ln=

化学和物理性质

溶解性	Soluble in 20 mg/mL of DMSO
敏感性	对光线和热敏感
熔点	127 °C
分子量	822.000 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	4
氢键受体数Hydrogen Bond Acceptor Count	13
可旋转键计数Rotatable Bond Count	7
精确质量Exact Mass	821.493 Da
单同位素质量Monoisotopic Mass	821.493 Da
拓扑极表面积Topological Polar Surface Area	179.000 Å²
重原子数Heavy Atom Count	58
形式电荷Formal Charge	0
复杂度Complexity	1480.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	14
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	2
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	2
共价键合单元计数Covalently-Bonded Unit Count	2

安全和危险性（GHS）

象形图	GHS06
信号词	Danger
危险声明	H301: 吞咽会中毒
预防措施声明	P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
WGK Germany	3
RTECS	KD4201200
Reaxy-Rn	43416939
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=43416939&ln=
Merck Index	9025

SDS英文版

技术规格说明书

Purity(HPLC)	80-100（%）
Melting point	125-129（℃）
Mass spectrum	Conforms to standard

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到11个结果

批号(Lot Number)	证书类型	日期	货号
D1719102	分析证书	24-07-08	F138016
I2203244	分析证书	24-06-17	F138016
I2203245	分析证书	24-06-17	F138016
K2421372	分析证书	24-04-23	F138016
K2421373	分析证书	24-04-23	F138016
H2309731	分析证书	23-08-14	F138016
H2301069	分析证书	23-08-10	F138016
H2301065	分析证书	23-08-10	F138016
H2301056	分析证书	23-08-10	F138016
K1928103	分析证书	23-07-17	F138016
A1925046	分析证书	22-09-21	F138016

显示更多⌵

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?

1. Feng Chen, Xiaoxia Yang, Huanhuan Li, Xiaodan Zeng, Ziwei Deng, Hongqiang Wang, Yuanxiang Jin, Chengfeng Qiu, Zhihua Shi. (2023) Improved LC–MS/MS method for the simultaneous quantification of tacrolimus and cyclosporine A in human blood and application to therapeutic drug monitoring. BIOMEDICAL CHROMATOGRAPHY, 37 (12): (e5751). [PMID:37772369] [10.1002/bmc.5751]
2. Xiaoqian Jiang, Xinxin Xu, Hua Kuang, Liqiang Liu, Liguang Xu, Aihua Qu, Chuanlai Xu. (2023) A gold-based immunochromatographic strip for the specific detection of tacrolimus in whole blood. Journal of Materials Chemistry B, 11 (20): (4464-4474). [PMID:37159048] [10.1039/D3TB00569K]
3. Fei Gong, Huihui Hu, Ying Ouyang, Zheng-Zheng Liao, Ying Kong, Jin-Fang Hu, Hua He, Ying Zhou. (2023) Physiologically-based pharmacokinetic modeling-guided rational combination of tacrolimus and voriconazole in patients with different CYP3A5 and CYP2C19 alleles. TOXICOLOGY AND APPLIED PHARMACOLOGY, 466 (116475). [PMID:36931438] [10.1016/j.taap.2023.116475]
4. Wang Hongkang, Ji Zhe, Feng Yanru, Yan Tianhua, Cao Yongbing, Lu Hui, Jiang Yuanying. (2022) Myriocin enhances the antifungal activity of fluconazole by blocking the membrane localization of the efflux pump Cdr1. Frontiers in Pharmacology, 13 [PMID:36618949] [10.3389/fphar.2022.1101553]
5. Qingfeng He, Fengjiao Bu, Qizhen Wang, Min Li, Jiaying Lin, Zhijia Tang, Wen Yao Mak, Xiaomei Zhuang, Xiao Zhu, Hai-Shu Lin, Xiaoqiang Xiang. (2022) Examination of the Impact of CYP3A4/5 on Drug–Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (9): (4485). [PMID:35562875] [10.3390/ijms23094485]
6. Gao Ping, Du Xiaoyi, Liu Lili, Xu Hua, Liu Maochang, Guan Xinlei, Zhang Chengliang. (2021) Astragaloside IV Alleviates Tacrolimus-Induced Chronic Nephrotoxicity via p62-Keap1-Nrf2 Pathway. Frontiers in Pharmacology, 11 [PMID:33536919] [10.3389/fphar.2020.610102]
7. Y. Chen, Y. Yang, F. Wang, X. Yang, F. Yao, K. Ming, W. Yuan, L. Zeng, J. Liu. (2018) Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1. POULTRY SCIENCE, 97 (2722). [PMID:29757435] [10.3382/ps/pey155]
8. Hongyan Zhang, Fengjiao Bu, Lei Li, Zheng Jiao, Guo Ma, Weimin Cai, Xiaomei Zhuang, Hai-Shu Lin, Jae-Gook Shin, Xiaoqiang Xiang. (2017) Prediction of Drug–Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 122 (3): (331-340). [PMID:28945011] [10.1111/bcpt.12914]
9. Xinhang Meng, Minfeng Shi, Jinfeng Qian, Yujie Luo, Liyuan Cui, Dajin Li, Songcun Wang. (2025) Tacrolimus (FK506) promotes placentation and maternal-fetal tolerance through modulating FASN-CEACAM1 pathway. Frontiers in Immunology, 16 (1522346). [PMID:40046057] [10.3389/fimmu.2025.1522346]

参考文献

1. Feng Chen, Xiaoxia Yang, Huanhuan Li, Xiaodan Zeng, Ziwei Deng, Hongqiang Wang, Yuanxiang Jin, Chengfeng Qiu, Zhihua Shi. (2023) Improved LC–MS/MS method for the simultaneous quantification of tacrolimus and cyclosporine A in human blood and application to therapeutic drug monitoring. BIOMEDICAL CHROMATOGRAPHY, 37 (12): (e5751). [PMID:37772369] [10.1002/bmc.5751]
2. Xiaoqian Jiang, Xinxin Xu, Hua Kuang, Liqiang Liu, Liguang Xu, Aihua Qu, Chuanlai Xu. (2023) A gold-based immunochromatographic strip for the specific detection of tacrolimus in whole blood. Journal of Materials Chemistry B, 11 (20): (4464-4474). [PMID:37159048] [10.1039/D3TB00569K]
3. Fei Gong, Huihui Hu, Ying Ouyang, Zheng-Zheng Liao, Ying Kong, Jin-Fang Hu, Hua He, Ying Zhou. (2023) Physiologically-based pharmacokinetic modeling-guided rational combination of tacrolimus and voriconazole in patients with different CYP3A5 and CYP2C19 alleles. TOXICOLOGY AND APPLIED PHARMACOLOGY, 466 (116475). [PMID:36931438] [10.1016/j.taap.2023.116475]
4. Wang Hongkang, Ji Zhe, Feng Yanru, Yan Tianhua, Cao Yongbing, Lu Hui, Jiang Yuanying. (2022) Myriocin enhances the antifungal activity of fluconazole by blocking the membrane localization of the efflux pump Cdr1. Frontiers in Pharmacology, 13 [PMID:36618949] [10.3389/fphar.2022.1101553]
5. Qingfeng He, Fengjiao Bu, Qizhen Wang, Min Li, Jiaying Lin, Zhijia Tang, Wen Yao Mak, Xiaomei Zhuang, Xiao Zhu, Hai-Shu Lin, Xiaoqiang Xiang. (2022) Examination of the Impact of CYP3A4/5 on Drug–Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (9): (4485). [PMID:35562875] [10.3390/ijms23094485]
6. Gao Ping, Du Xiaoyi, Liu Lili, Xu Hua, Liu Maochang, Guan Xinlei, Zhang Chengliang. (2021) Astragaloside IV Alleviates Tacrolimus-Induced Chronic Nephrotoxicity via p62-Keap1-Nrf2 Pathway. Frontiers in Pharmacology, 11 [PMID:33536919] [10.3389/fphar.2020.610102]
7. Y. Chen, Y. Yang, F. Wang, X. Yang, F. Yao, K. Ming, W. Yuan, L. Zeng, J. Liu. (2018) Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1. POULTRY SCIENCE, 97 (2722). [PMID:29757435] [10.3382/ps/pey155]
8. Hongyan Zhang, Fengjiao Bu, Lei Li, Zheng Jiao, Guo Ma, Weimin Cai, Xiaomei Zhuang, Hai-Shu Lin, Jae-Gook Shin, Xiaoqiang Xiang. (2017) Prediction of Drug–Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 122 (3): (331-340). [PMID:28945011] [10.1111/bcpt.12914]
9. Xinhang Meng, Minfeng Shi, Jinfeng Qian, Yujie Luo, Liyuan Cui, Dajin Li, Songcun Wang. (2025) Tacrolimus (FK506) promotes placentation and maternal-fetal tolerance through modulating FASN-CEACAM1 pathway. Frontiers in Immunology, 16 (1522346). [PMID:40046057] [10.3389/fimmu.2025.1522346]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

=

浓度

x

体积

x

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

x

体积 1 (V1)

=

浓度 2 (C2)

x

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

=

质量（小瓶）

÷

所需的复溶浓度

货号 (SKU)	包装规格	是否现货
F138016-10mg	10mg	现货
F138016-100mg	100mg	现货
F138016-50mg	50mg	现货
F138016-500mg	500mg	期货
F138016-250mg	250mg	期货
F138016-1g	1g	现货

他克莫司一水合物

库存信息

库存信息

库存信息

库存信息

库存信息

库存信息

基本描述

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

显示更多⌵

此产品的引用文献

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器