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迷迭香酸

GPR35激动剂;抗炎,抑制细胞生长和抗病毒
规格或纯度: 97%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
R109805-250mg
250mg 现货 Stock Image
R109805-1g
1g 现货 Stock Image
R109805-5g
5g 现货 Stock Image
R109805-25g
25g 期货 Stock Image

基本描述

别名 3,4-二羟基肉桂酸 | (R)-O-(3,4-二羟基肉桂酰)-3-(3,4-二羟苯基)乳酸 | 3,4-二羟基肉桂酸 ( R )-1-羧基-2-(3,4-二羟基苯基)乙酯
英文别名 (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid | (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-propanoic acid | HMS3649C22 | SMR000445579 | MFCD00017740 | AS-35341 | R-(+)-2-(3,4-Dih
规格或纯度 97%
英文名称 Rosmarinic acid
生化机理 迷迭香酸具有抗氧化、抗炎和抗菌活性。在认知能力、阿尔茨海默病预防、肾脏疾病治疗、心脏保护和肿瘤化学预防等方面具有广阔的应用前景。
储存温度 充氩
运输条件 常规运输
产品介绍

迷迭香酸是一种具有抗氧化和抗炎作用的生物活性植物酚类化合物。
应用
迷迭香酸被用作模型化合物,以研究其在动物模型中的生物学效应。多项研究表明其具有以下作用:
抑制肾病。
抑制硫酸庆大霉素(GS)诱导的肾脏氧化损伤。
缓解噪音引起的听力损失。
缓解抑郁。
缓解创伤后应激障碍(PTSD)样症状。

An activator of GPR35.

名称和标识符

PubChem SID 488195247
PubChem SID url https://pubchem.ncbi.nlm.nih.gov/substance/488195247
IUPAC Name (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid
INCHI InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
InChi Key DOUMFZQKYFQNTF-WUTVXBCWSA-N
Canonical SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2
Isomeric SMILES C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O
WGK Germany 3
PubChem CID 5281792
分子量 360.31
Beilstein号 2227587

化学和物理性质

溶解性 溶于water, 最高浓度 (mg/mL): None, 最高浓度(mM): 100
敏感性 对空气敏感
熔点 171-175°C

安全和危险性(GHS)

象形图
ghs06

Toxic

ghs09

Environmental Hazard

信号词 Danger
危险声明 H301: Toxic if swallowed
H400: Very toxic to aquatic life
预防措施声明 P273,P321,P405,P501,P264,P270,P391,P330,P301+P316
WGK Germany 3
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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参考文献

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55. Meng-Ge Lv,Wen-Qiong Chen,Shi-Qi Weng,Hou-Yang Chen,Yi-Min Cheng,Tao Luo.  (2018-07-17)  Rosmarinic acid compromises human sperm functions by an intracellular Ca2+ concentration-related mechanism..  Reproductive toxicology (Elmsford, N.Y.),  81  ():  (58-63).  [PMID:30009954]
56. Le Qu,Huamin Xu,Wenting Jia,Hong Jiang,Junxia Xie.  (2018-10-22)  Rosmarinic acid protects against MPTP-induced toxicity and inhibits iron-induced α-synuclein aggregation..  Neuropharmacology,  144  ():  (291-300).  [PMID:30342981]
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