Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta. Amlodipine is attributed to distinct membrane physico-chemical interactions. Amlodipine contributes to distinct membrane biophysical interactions that lead to potent lipid antioxidant effects, independent of calcium channel modulation. Amlodipine increases plaque smooth muscle cell content (P<0.05), whereas atenolol decreases plaque inflammation. Amlodipine attenuates intracellular neuronal Ca²⁺ increases elicited by KCl depolarization but does not affect Ca²⁺ changes triggered by N-methyl-D-aspartate receptor activation. Amlodipine also inhibits free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca²⁺ channel modulation.

In vivo

Amlodipine results in regression of cardiovascular hypertrophy and amelioration of endothelial dysfunction in spontaneously hypertensive rats. Amlodipine significantly reduces aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. Amlodipine has antihypertensive and antioxidant activity in vivo, which effectively inhibits many of the oxidative stress-dependent mechanisms involved in Ang II-mediated cardiovascular injury.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥95%

规格

英文别名

UK-48340

规格或纯度

Moligand™, 10mM in DMSO

英文名称

Amlodipine

生化机理

氨氯地平（UK-48340）是一种长效钙通道阻滞剂，用于降低血压和预防胸痛。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

门控抑制剂

作用机制

Ca v1.2的门控抑制剂;Ca v1.3的门控抑制剂;P2X4的异位调节剂

名称和识别符

EC号

618-119-7

分子类型

小分子

Isomeric SMILES

CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN

分子量

408.88

Reaxy-Rn

3570229

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3570229&ln=

高级数据

关联靶点（人）

CACNA1C Tclin 电压依赖性 L 型钙通道亚基 α-1C(Voltage-dependent L-type calcium channel subunit alpha-1C) (2 活性数据)

点击查看靶蛋白信息： CACNA1C

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CACNA1D Tclin 电压依赖性 L 型钙通道亚基 alpha-1D(Voltage-dependent L-type calcium channel subunit alpha-1D) (1 活性数据)

点击查看靶蛋白信息： CACNA1D

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

KCNK2 Tclin 钾通道亚家族 K 成员 2(Potassium channel subfamily K member 2) (1 活性数据)

点击查看靶蛋白信息： KCNK2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

化学和物理性质

熔点

178-179 ºC

安全和危险性（GHS）

象形图

GHS02

信号词

警告

危险声明

H227: 可燃液体

预防措施声明

P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。

P403+P235: 存放在通风良好的地方。保持低温。

P501: 将内容物/容器送到批准的废物处理厂处理

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

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批号(Lot Number)	证书类型	货号
B2310205	分析证书	A408387

技术文档和文章

OSF/ASF 双通道工具箱：四元小环磺酰氟的分流反应、条件旋钮与选型导航

目录：技术文章

探索主题:

分子砌块氧杂环丁烷氮杂环丁烷

OSF/ASF Dual-Channel Toolbox: Divergent Reactions of Four-Membered Ring Sulfonyl Fluorides, Condition “Knobs,” and Selection Navigation

目录：技术文章

探索主题:

oxetanes azetidines molecular building blocks

钙通道阻滞剂的作用机制、分类特征与实验应用

目录：技术文章

探索主题:

钙成像钙通道阻滞剂 L型钙通道二氢吡啶类电压门控钙通道 Cav1.2 膜片钳神经递质释放

Mechanisms of Action, Classification Characteristics, and Experimental Applications of Calcium Channel Blockers

目录：技术文章

探索主题:

Calcium Imaging Cav1.2 L-type calcium channels Calcium Channel Blockers Dihydropyridines Voltage-Gated Calcium Channels Patch Clamp Neurotransmitter Release

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