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| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
当归素
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A424489-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 异补骨脂素 |
|---|---|
| 英文别名 | 4-Hydroxy-5-benzofuranacrylic acid gamma-lactone | A829042 | 2-Propenoic acid, 3-(4-hydroxy-5-benzofuranyl)-, delta-lactone | Furo[5',8]coumarin | Angelicin, analytical standard | 2H-Furo(2,3-H)-1-benzopyran-2-one | Angelicin plus ultraviolet A radiation |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Angelicin |
| 生化机理 | 角呋喃香豆素具有多种光生物效应。在长波紫外线照射下，会与双链 DNA 形成单加成物，并与不饱和脂肪酸发生反应。抑制艾氏腹水瘤细胞的 DNA 和 RNA 合成以及细胞复制。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
An angular furocoumarin, may be used as a photoactivatable molecule that reacts with DNA and unsaturated fatty acids to form monoadducts. Angelicin may be studied as a potential phototherapeutic and to understand its mechanisms of action and effects on RNA and DNA synthesis. An angular furocoumarin, may be used as a photoactivatable molecule that reacts with DNA and unsaturated fatty acids to form monoadducts. Angelicin may be studied as a potential phototherapeutic and to understand its mechanisms of action and effects on RNA and DNA synthesis. |
关联靶点（人）
MAOA
Tclin
胺氧化酶[含黄素]A(Amine oxidase [flavin-containing] A)
(2 活性数据)
ALDH2
Tclin
Aldehyde dehydrogenase
(509 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MAOB
Tclin
Monoamine oxidase B
(8835 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP1A1
Tchem
Cytochrome P450 1A1
(1169 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ALDH1A1
Tchem
Aldehyde dehydrogenase 1A1
(77053 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ALDH3A1
Tchem
Aldehyde dehydrogenase dimeric NADP-preferring
(307 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
NFKB1
Tclin
Nuclear factor NF-kappa-B p105 subunit
(1459 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
BACE1
Tchem
Beta-secretase 1
(15641 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HL-60
(67320 活性数据)
HT-1080
(3966 活性数据)
K562
(73714 活性数据)
LoVo
(4724 活性数据)
MCF7
(126967 活性数据)
A549
(127892 活性数据)
Jurkat
(10389 活性数据)
SIRT1
Tchem
NAD-dependent deacetylase sirtuin 1
(3505 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
关联靶点（其它种属）
Mus musculus (284745 活性数据)
Ehrlich (1318 活性数据)
B16-F10 (4610 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | furo[2,3-h]chromen-2-one |
| INCHI | InChI=1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H |
| InChi Key | XDROKJSWHURZGO-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC2=C(C=CO2)C3=C1C=CC(=O)O3 |
| Isomeric SMILES | C1=CC2=C(C=CO2)C3=C1C=CC(=O)O3 |
| RTECS | LV0940000 |
| 分子量 | 186.16 |
| Reaxy-Rn | 153970 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=153970&ln= |
化学和物理性质
| 敏感性 | 对热敏感 |
|---|---|
| 沸点 | 104 °C/4 mmHg |
| 熔点 | 140 °C |
| 分子量 | 186.160 g/mol |
| XLogP3 | 2.000 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 186.032 Da |
| 单同位素质量Monoisotopic Mass | 186.032 Da |
| 拓扑极表面积Topological Polar Surface Area | 39.400 Ų |
| 重原子数Heavy Atom Count | 14 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 284.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS08, GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H351: 怀疑引起遗传缺陷 H302: 吞食有害 H312: 皮肤接触有害 H332: 吸入有害 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P318: 如果暴露或担心，请就医。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| RTECS | LV0940000 |
| Reaxy-Rn | 153970 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=153970&ln= |
技术规格说明书
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Appearance(Colorless Transparent Liquid) | Pass |
| Record the entire process by video | Conform |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
| 1. Liangliang Han, Libo Zhang, Yuedong He, Lijing Liao, Junde Li, Sheng Xu, Yucheng Zhao, Xiaohong Bian, Yuanzheng Xia. (2023) Three carbon-/oxygen-prenyltransferases responsible for furanocoumarin synthesis in Angelica dahurica. INDUSTRIAL CROPS AND PRODUCTS, 200 (116814). [10.1016/j.indcrop.2023.116814] |
| 2. Yuling Chen, Rong Wang, Zilin Chen. (2018) Sensitive determination of psoralen and isopsoralen in Fructus Psoraleae by online solid phase microextraction with a porphyrin-based porous organic polymer modified capillary. Analytical Methods, 11 (1): (29-35). [10.1039/C8AY01885E] |
| 3. Li Xiaotian, Yu Chunbo, Hu Yi, Xia Xinyi, Liao Yue, Zhang Jing, Chen Huiwen, Lu Weili, Zhou Wei, Song Zhongchen. (2018) New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects. Frontiers in Cellular and Infection Microbiology, 8 [PMID:29922598] [10.3389/fcimb.2018.00178] |
| 4. Sun Yujing, Wang Yihua, Zhang Le, Ye Xingqian, Guo Jingtong. (2024) Furanocoumarin profiles and inhibitory effects on cytochrome P450 activity of whole citrus fruit. Food Quality and Safety, [10.1093/fqsafe/fyae038] |
| 5. Kai Tian, Jiang Zhu, Xinghui Qiu. (2024) Metabolism of Furanocoumarins by Three Recombinant CYP9A Proteins From the Polyphagous Cotton Bollworm Helicoverpa armigera. ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 117 (3): (e70004). [PMID:39494619] [10.1002/arch.70004] |
参考文献
| 1. Liangliang Han, Libo Zhang, Yuedong He, Lijing Liao, Junde Li, Sheng Xu, Yucheng Zhao, Xiaohong Bian, Yuanzheng Xia. (2023) Three carbon-/oxygen-prenyltransferases responsible for furanocoumarin synthesis in Angelica dahurica. INDUSTRIAL CROPS AND PRODUCTS, 200 (116814). [10.1016/j.indcrop.2023.116814] |
| 2. Yuling Chen, Rong Wang, Zilin Chen. (2018) Sensitive determination of psoralen and isopsoralen in Fructus Psoraleae by online solid phase microextraction with a porphyrin-based porous organic polymer modified capillary. Analytical Methods, 11 (1): (29-35). [10.1039/C8AY01885E] |
| 3. Li Xiaotian, Yu Chunbo, Hu Yi, Xia Xinyi, Liao Yue, Zhang Jing, Chen Huiwen, Lu Weili, Zhou Wei, Song Zhongchen. (2018) New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects. Frontiers in Cellular and Infection Microbiology, 8 [PMID:29922598] [10.3389/fcimb.2018.00178] |
| 4. Sun Yujing, Wang Yihua, Zhang Le, Ye Xingqian, Guo Jingtong. (2024) Furanocoumarin profiles and inhibitory effects on cytochrome P450 activity of whole citrus fruit. Food Quality and Safety, [10.1093/fqsafe/fyae038] |
| 5. Kai Tian, Jiang Zhu, Xinghui Qiu. (2024) Metabolism of Furanocoumarins by Three Recombinant CYP9A Proteins From the Polyphagous Cotton Bollworm Helicoverpa armigera. ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 117 (3): (e70004). [PMID:39494619] [10.1002/arch.70004] |