Armenian Hamster anti Mouse TNF Receptor I Antibody, Monoclonal (55R-170), could be used for Flow, WB, IP, Blocking, Functional Assays, Neutralization and so on. Application Flow: ≤1.0µg/100w cells WB: Use at an assay dependent concentration. IP: Use at an assay dependent concentration. Blocking: Use at an assay dependent concentration. Functional Assays: Use at an assay dependent concentration. Neutralization: Use at an assay dependent concentration. Protein Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
TNF Receptor I Armenian Hamster mAb (Ab131819) - Flow Cytometry Flow Cytometry analysis of L929 cells labelling TNF Receptor I (red) with TNF Receptor I Armenian Hamster mAb (Ab131819) at 5.0 μg/mL for 1 hour at 4°C, and detected with AF488-conjugated affinipure goat anti-Armenian Hamster IgG. Blue - Isotype control, Armenian Hamster IgG (Ab135991). Black - Unlabelled control, cells without incubation with primary antibody.