Rat anti Mouse Transferrin Receptor/CD71 Antibody, Monoclonal (8D3), could be used for Flow, in vivo depletion of CD71+ cells, ICC, IF, IHC, WB and so on. Application: Flow: Use at an assay dependent concentration. in vivo depletion of CD71+ cells: Use at an assay dependent concentration. ICC/IF: Use at an assay dependent concentration. IHC: Use at an assay dependent concentration. WB: Use at an assay dependent concentration. Protein Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
规格
产品名称
Transferrin Receptor/CD71 Rat mAb
别名
转铁蛋白受体(TFR)抗体 | Transferrin Receptor/CD71抗体 | 转铁蛋白受体/CD71 大鼠 mAb
Transferrin Receptor/CD71 Rat mAb (Ab132256) - Flow Cytometry Flow Cytometry analysis of mouse bone marrow cells labelling Transferrin Receptor/CD71 (red) with Transferrin Receptor/CD71 Rat mAb (Ab132256) conjugated with biotin at 0.12 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Rat IgG Isotype Control Antibody (Biotin) (Ab180310). Black - Unlabelled control, cells without incubation with primary antibody.
ZJ24F0910323
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