Tarlatamab (anti-DLL3&CD3) is a bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3). DLL3 is a target that is selectively expressed in small-cell lung cancer (SCLC) tumors, but with minimal normal tissue expression. Tarlatamab (anti-DLL3&CD3) has the KDs of 0.64 nM and 0.50 nM for human and nonhuman primate (NHP) DLL3, respectively. Tarlatamab (anti-DLL3&CD3) has the KDs of 14.9 nM and 12 nM for human and NHP CD3, respectively. Tarlatamab (anti-DLL3&CD3) is a first-in-class HLE BiTE immuno-oncology therapy targeting DLL3 and has the potential for SCLC research.
DLL3: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
CD3: The CD3 complex mediates signal transduction.
宿主种属
人(Human)
特异性
DLL3; CD3E
种属反应性
人(Human)
偶联
Unconjugated
克隆类型
重组抗体
Format
scFv-scFv
轻链亚型
kappa - lambda
纯化方法
Protein A purified
浓度
见COA
CAS编号和信息
2307488-83-9
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
10mM PBS, pH 7.4.
防腐剂
No
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
稳定性与储存
短期储存2-8℃(1-2周);长期储存-80℃(36个月);收货后建议分装,避免反复冻融。
图片
Tarlatamab (anti-DLL3&CD3) (Ab182980) - Flow Cytometry Flow Cytometry analysis of Jurkat cells labelling DLL3&CD3 (red) with Tarlatamab (anti-DLL3&CD3) (Ab182980) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Tarlatamab (anti-DLL3&CD3) (Ab182980) - SEC The purity of Tarlatamab (anti-DLL3&CD3) (Ab182980) is more than 95% verified by HPLC.