TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
宿主种属
亚美尼亚仓鼠(Armenian hamster)
特异性
Mouse TCR γ/δ
种属反应性
小鼠(Mouse)
免疫原
C57BL/6J intraepithelial lymphocytes
阳性对照
Flow Cytometry: C57BL/6 mouse lymph node cells
偶联
Unconjugated
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 8.0
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at 2-8℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Recombinant TCR γ/δ Antibody (Ab219619) - Flow Cytometry Two-color flow cytometric analysis of TCR γ/δ expression on mouse lymph node cells. C57BL/6 mouse lymph node cells were stained with CD45R Rat mAb (AF647) (Ab191663) and either Armenian Hamster IgG Isotype Control Antibody (Biotin) (Ab191741; Left panel) or Recombinant TCR γ/δ Antibody (Ab219619; Right panel) conjugated with biotin at 0.2 μg/mL for 1 hour at 4°C and detected with SA-PE (rp156150). Two-color flow cytometric dot plots showing the correlated expression of CD45R versus TCR γ/δ (or Isotype control staining) were derived from gated events with the forward and side light-scatter characteristics of viable lymph node cells.
Recombinant TCR γ/δ Antibody (Ab219619) - SEC The purity of Recombinant TCR γ/δ Antibody (Ab219619) is more than 95% verified by HPLC.
ZJ25F0622918
危险品化学品经营许可证（带存储）