Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells.
Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity).
Post-translational modification
Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. Ubiquitinated by RNF128 via 'Lys-27'-linked polyubiquitination, facilitating its degradation through the lysosomal pathway.
宿主种属
小鼠(Mouse)
特异性
Human Interleukin-3 receptor subunit alpha
种属反应性
人(Human)
免疫原
Human IL-3Rα transfected COS cells.
阳性对照
Flow Cytometry: Human peripheral blood lymphocytes
偶联
Unconjugated
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 8.0
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融.
图片
Recombinant IL3RA/CD123 Antibody (Ab219621) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling IL3RA/CD123 with Recombinant IL3RA/CD123 Antibody (Ab219621) (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with Mouse IgG Isotype Control Antibody (Ab170221) (left panel) and detected with AF 488 - conjugated affinipure goat anti-Mouse IgG.
Recombinant IL3RA/CD123 Antibody (Ab219622) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling IL3RA/CD123 (red) with Recombinant IL3RA/CD123 Antibody (Ab219621) at 0.2 μg/mL for 1 hour at 4°C and detected with AF488 - conjugated affinipure goat anti-Mouse IgG. Blue - Mouse IgG Isotype Control Antibody (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.
Recombinant IL3RA/CD123 Antibody (Ab219621) - SEC The purity of Recombinant IL3RA/CD123 Antibody (Ab219621) is more than 95% verified by HPLC.
ZJ25F0723693
危险品化学品经营许可证（带存储）