Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions.
Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes.
Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions.
Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils.
Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal.
Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes.
Modulates bradykinin receptor BDKRB2 activation.
Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells.
Induces susceptibility to atherosclerosis (By similarity).
Isoform Delta15, Does not protect against apoptosis.
宿主种属
小鼠(Mouse)
特异性
Human CD31
种属反应性
人(Human)
免疫原
Human CD31
阳性对照
Flow Cytometry: Human peripheral blood lymphocytes
偶联
Unconjugated
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 8.0
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存2-8℃(1-2周);长期储存-20℃(24个月);收货后建议分装,避免反复冻融.
图片
Recombinant CD31 Antibody (Ab222916) - Flow Cytometry Flow Cytometry analysis of human peripheral blood monocytes labelling CD31 (red) with Recombinant CD31 Antibody (Ab222916) at 1.0 μg/mL for 1 hour at 4°C and detected with AF 647 - conjugated affinipure goat anti-Mouse IgG. Blue - Mouse IgG Isotype Control Antibody (Ab180306). Black - Unlabelled control, cells without incubation with primary antibody.
Recombinant CD31 Antibody (Ab222916) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD31 (red) with Recombinant CD31 Antibody (Ab222916) at 1.0 μg/mL for 1 hour at 4°C and detected with AF 647 - conjugated affinipure goat anti-Mouse IgG. Blue - Mouse IgG Isotype Control Antibody (Ab180306). Black - Unlabelled control, cells without incubation with primary antibody.
Recombinant CD31 Antibody (Ab222916) - Flow Cytometry Flow Cytometry analysis of human peripheral blood mononuclear cells labelling CD31 with Recombinant CD31 Antibody (Ab222916) (right panel) at 1.0 μg/mL for 1 hour at 4°C, compared with Mouse IgG Isotype Control Antibody (Ab170221) (left panel) and detected with AF 647 - conjugated affinipure goat anti-Mouse IgG.
Recombinant CD31 Antibody (Ab222916) - SEC The purity of Recombinant CD31 Antibody (Ab222916) is more than 95% verified by HPLC.