CD_antigen=CD3d antibody | CD3D antibody | CD3G antibody | T cell antigen receptor delta polypeptide antibody | T cell antigen receptor gamma polypeptide antibody | T cell rearranging gene gamma antibody | T cell receptor delta antibody | T cell receptor
规格或纯度
ExactAb™, 已验证, 重组, 0.5mg/mL
生化机理
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
宿主种属
亚美尼亚仓鼠(Armenian hamster)
特异性
Mouse TCR γ/δ
种属反应性
小鼠(Mouse)
免疫原
C57BL/6J intraepithelial lymphocytes
阳性对照
Flow Cytometry: C57BL/6 mouse lymph node cells
偶联
AF405
Excitation(nm)
Violet Laser(405nm)
Emission(nm)
422nm
Ex/Em(nm)
Ex:401nm;Em:422nm
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
0.5mg/mL
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.
防腐剂
0.05% Proclin300
储存条件
2-8°C储存,避光,禁止冷冻
运输条件
低温运输,禁止冷冻
稳定性与储存
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
图片
Recombinant TCR γ/δ Antibody (AF405) (Ab223783) - Flow Cytometry Two-color flow cytometric analysis of TCR γ/δ expression on C57BL/6 mouse lymph node cells. C57BL/6 mouse lymph node cells were stained with CD45R Rat mAb (AF647) (Ab191663) and either Armenian Hamster IgG (AF405) (Ab211668; Left panel) or Recombinant TCR γ/δ Antibody (AF405) (Ab223783) at 0.1μg/test.
应用
应用名称
稀释比例
Flow Cytometry
≤1.0μg/ test
For flow cytometric staining, the suggested use of this reagent is ≤1.0 μg per million cells in 100 µL staining volume.
ZJ25F0927560
危险品化学品经营许可证（带存储）