BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein ( BMP ). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β , increases β-catenin signaling and synergistically regulates Id2 and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research.