| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B424926-1ml |
1ml |
现货  |
|
| 别名 | 贝他定 | N-[(2S,3R)-3-氨基-2-羟基-4-苯基丁酰基]-L-亮氨酸 |
|---|---|
| 英文别名 | (3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine | UBENIMEX [WHO-DD] | 4-methyl-pyrimidin-2-ylamine | L-Leucine, N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]- | KBioGR_000273 | N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine | SMR000059165 |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Bestatin |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
氨基肽酶的抑制剂。急、慢性细胞性白血病等病的辅助 A competitive inhibitor of aminopeptidases, especially aminopeptidase B, leucine aminopeptidase and tripeptide aminopeptidase. Not an inhibitor of carboxypeptidases. |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 261-529-2 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid |
| INCHI | InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 |
| InChi Key | VGGGPCQERPFHOB-RDBSUJKOSA-N |
| Canonical SMILES | CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O |
| Isomeric SMILES | CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](CC1=CC=CC=C1)N)O |
| WGK Germany | 3 |
| RTECS | OH2915000 |
| 分子量 | 308.37 |
| Reaxy-Rn | 3036818 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3036818&ln= |
| 比旋光度 | -19° (C=1,1mol/L HCl) |
|---|---|
| 熔点 | >200 °C |
| 分子量 | 308.370 g/mol |
| XLogP3 | -1.000 |
| 氢键供体数Hydrogen Bond Donor Count | 4 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 8 |
| 精确质量Exact Mass | 308.174 Da |
| 单同位素质量Monoisotopic Mass | 308.174 Da |
| 拓扑极表面积Topological Polar Surface Area | 113.000 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 367.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 3 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | OH2915000 |
| Reaxy-Rn | 3036818 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3036818&ln= |
| Merck Index | 9842 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| Concentration(Compounding value) | 9-11（mmol/L） |
|---|---|
| Record the entire process by video | Conform |
| 1. Yinghua Liu, Jianfeng Zeng, Qing Li, Minqian Miao, Zhuorun Song, Min Zhao, Qingqing Miao, Mingyuan Gao. (2022) An APN-Activated Chemiluminescent Probe for Image-Guided Surgery of Malignant Tumors. Advanced Optical Materials, 10 (14): (2102709). [10.1002/adom.202102709] |
| 2. Xiao-lin Hou, Xiang Dai, Jie Yang, Bin Zhang, Dong-hui Zhao, Chao-qing Li, Zhong-yuan Yin, Yuan-di Zhao, Bo Liu. (2020) Injectable polypeptide-engineered hydrogel depot for amplifying the anti-tumor immune effect induced by chemo-photothermal therapy. Journal of Materials Chemistry B, 8 (37): (8623-8633). [PMID:32821893] [10.1039/D0TB01370F] |
| 1. Yinghua Liu, Jianfeng Zeng, Qing Li, Minqian Miao, Zhuorun Song, Min Zhao, Qingqing Miao, Mingyuan Gao. (2022) An APN-Activated Chemiluminescent Probe for Image-Guided Surgery of Malignant Tumors. Advanced Optical Materials, 10 (14): (2102709). [10.1002/adom.202102709] |
| 2. Xiao-lin Hou, Xiang Dai, Jie Yang, Bin Zhang, Dong-hui Zhao, Chao-qing Li, Zhong-yuan Yin, Yuan-di Zhao, Bo Liu. (2020) Injectable polypeptide-engineered hydrogel depot for amplifying the anti-tumor immune effect induced by chemo-photothermal therapy. Journal of Materials Chemistry B, 8 (37): (8623-8633). [PMID:32821893] [10.1039/D0TB01370F] |
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