本品主要成分为硅藻土、高岭土、硅微粉、凝血酶、硅油、无水乙醇等，各成分按科学比例配比，确保促凝效果稳定且不干扰临床检测。
本品为淡黄色悬浊液体，静置后会出现沉淀；具有加速血液凝固的作用，且对临床生化项目检测无影响。
适用范围
本品可用于制备真空采血管及注射式采血管，应用于临床医学检验工作中。化验人员可在同一器皿内完成血样采集、快速分离血清及样品传递等操作，提升检验效率。
促凝原理
本品通过激活血浆和血小板中的部分凝血因子，促进凝血活酶及纤维蛋白凝块的生成，加速血球凝块收缩，从而实现血清的快速分离，满足临床检验的时效需求。
促凝能力
在25℃条件下，20μl本品可使5ml血样在3-5分钟内快速凝固；血液凝固后，静置15-20分钟即可上机离心（建议离心条件：相对离心力RCF=1200-1500g，离心时间8-10分钟）分离血清。离心后血块收缩良好，血清析出量充足，分离状态佳，不干扰血液标本的后续检测。当环境温度低于20℃时，可适当延长采血后静置时间，以保证良好的促凝效果。
用法与用量
1. 本品可采用机器喷雾方式添加，添加过程中需持续搅拌，保持悬浊液均匀，确保各有效成分添加量一致。
2. 可通过机械搅拌、电磁搅拌、气动搅拌等方式维持悬浊液均匀，搅拌速度根据实际操作情况调整。
3. 添加完成后，需对促凝剂进行烘干处理（水剂促凝剂无需烘干）。建议采用热风烘干，温度控制在60-70℃，通过两组热风管热风烘干3次，每次2秒，以彻底烘干为准。
4. 如需进行辐照灭菌，建议辐照剂量控制在8-25kGy。
5. 用量标准：一般情况下，20μl本品可快速促凝5ml血样，用量误差范围控制在±10%。具体推荐用量如下表所示：
血样体积
| 建议添加剂量
|
3-4 mL
| 15 μL
|
5-7 mL
| 20 μL
|
8-15 mL
| 30 μL |
注意事项
1. 若血液凝血不充分，可能导致血球及纤维蛋白丝挂壁、轻度溶血；部分患者血液若一次凝血不完全，可能出现凝血过程中止、纤维蛋白析出，或离心后无血清分离等情况。
2. 若凝血时间少于15分钟即上机离心，可能导致纤维蛋白丝二次析出，漂浮于血清中，极易造成检测仪器探针堵塞。
3. 本品需密封保存，环境温度不得超过35℃，低温储存可更好地保持其促凝活性。有效期3年。
The main components of this product are diatomaceous earth, kaolin, silica powder, thrombin, silicone oil, anhydrous ethanol, etc. Each component is proportioned according to a scientific ratio to ensure a stable coagulation-promoting effect without interfering with clinical testing.
This product is a light yellow turbid liquid, which may precipitate upon standing. It accelerates blood coagulation and has no impact on clinical biochemical tests.
Scope of Application
This product can be used in the preparation of vacuum blood collection tubes and syringe-based blood collection tubes for clinical medical laboratory work. Laboratory personnel can perform blood sample collection, rapid serum separation, and sample transfer within a single container, improving testing efficiency.
Coagulation Principle
This product activates certain coagulation factors in plasma and platelets, promoting the generation of thromboplastin and fibrin clots, and accelerating the contraction of blood cell clots. This enables rapid serum separation, meeting the timeliness requirements of clinical testing.
Coagulation Capacity
At 25°C, 20μl of this product can rapidly coagulate 5ml of blood within 3-5 minutes. After coagulation, allow the blood to stand for 15-20 minutes before centrifuging to separate the serum (recommended centrifugation conditions: Relative Centrifugal Force (RCF) = 1200-1500g, centrifugation time: 8-10 minutes). After centrifugation, the blood clot retracts well, providing an adequate volume of separated serum with excellent separation quality, without interfering with subsequent testing of the blood sample. If the ambient temperature is below 20°C, the standing time after blood collection can be appropriately extended to ensure a good coagulation-promoting effect.
Usage and Dosage
1. This product can be applied using machine spraying. During the application process, continuous stirring is required to maintain the uniformity of the turbid liquid and ensure consistent addition of each active ingredient.
2. Mechanical stirring, electromagnetic stirring, or pneumatic stirring can be used to maintain the uniformity of the turbid liquid. The stirring speed should be adjusted according to the actual operational conditions.
3. After application, the coagulant needs to be dried (water-based coagulants do not require drying). Hot air drying is recommended, with the temperature controlled at 60-70°C. Dry using two sets of hot air tubes for 3 cycles, each lasting 2 seconds, until completely dry.
4. If irradiation sterilization is required, the recommended irradiation dose is 8-25 kGy.
5. Dosage Standard: Generally, 20μl of this product can rapidly coagulate 5ml of blood, with a dosage error range controlled within ±10%. Specific recommended dosages are shown in the table below:
Blood Sample Volume
| Recommended Dosage
|
3-4 mL
| 15 μL
|
5-7 mL
| 20 μL
|
8-15 mL
| 30 μL |
Precautions
Insufficient blood coagulation may lead to blood cells and fibrin strands adhering to the tube wall, or mild hemolysis. If coagulation is incomplete in some patient blood samples, it may result in the coagulation process stopping, fibrin precipitation, or no serum separation after centrifugation.
If centrifugation is performed less than 15 minutes after coagulation, it may lead to secondary precipitation of fibrin strands, which will float in the serum and can easily cause probe blockage in testing instruments.
This product must be stored sealed, with the ambient temperature not exceeding 35°C. Low-temperature storage better preserves its coagulation-promoting activity. The shelf life is 3 years.
ZJ26F0434462
危险品化学品经营许可证（带存储）