计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Information
Ciclopirox ethanolamine Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator .
In vitro
Ciclopirox significantly inhibits the growth of C. albicans strain SC5314 cells, with MIC80s of 1.0-2.0 μg/mL, growth decreased dramatically at the concentrations of >0.6 μg/mL, and almost complete growth inhibition at concentration of 0.7 μg/mL, unlike fluconazole which shows a much wider range of concentrations with intermediate inhibition. Like iron chelator bipyridine, Ciclopirox reduces cell growth by binding to iron ions, which can be reversed by addition of FeCl3. Moreover, Ciclopirox treatment at subinhibitory concentration (0.6 μg/mL) only moderately reduces the virulence genes such as genes encoding secreted proteinases or lipases, but leads to a distinct up- or down-regulation of genes encoding iron permeases or transporters (FTR1, FTR2, and FTH1), a copper permease (CCC2), an iron reductase (CFL1), and a siderophore transporter (SIT1). Although the Candida drug resistance genes CDR1 and CDR2 are up-regulated after Ciclopirox treatment, no change in resistance or increased tolerance could be observed even after an incubation period of 6 months, in contrast to fluconazole in which the MICs for cells noticeably increase after 2 months. Ciclopirox inhibits the growth of Aspergillus fumigatus strain B5233 with IC50 of 4.22 μM, more potently compared with deferiprone with IC50 of 1.29 mM.
In vivo
Cell Data
cell lines：NALM-6 cells
Concentrations：Dissolved in DMSO, final concentrations 10 μg/mL
Incubation Time：1-10 hours
Powder Purity:≥98%
规格
英文别名
2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-, compd. with 2-aminoethanol (1:1)
规格或纯度
10mM in DMSO
英文名称
Ciclopirox ethanolamine
生化机理
环吡酮胺乙醇胺（Ciclopirox olamine，HOE 296）是一种广谱抗真菌剂，具有铁螯合剂的作用。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
255-464-9
分子类型
小分子
Isomeric SMILES
CC1=CC(=O)N(C(=C1)C2CCCCC2)O.C(CO)N
分子量
268.35
Reaxy-Rn
6494273
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6494273&ln=
技术文档
高级数据
化学和物理性质
溶解性
Solubility (25°C) In vitro DMSO: 66 mg/mL (101.82 mM); Ethanol: 1 mg/mL (1.54 mM); Water: Insoluble;
安全和危险性（GHS）
信号词
危险
危险声明
H271: 可能引起火灾或爆炸； 强氧化剂
H314: 造成严重的皮肤灼伤和眼睛损伤
H317: 可能引起皮肤过敏反应
H410: 对水生生物有剧毒并具有长期持续影响
WGK Germany
2
RTECS
UU7785500
个人防护装备
dust mask type N95 (US),Eyeshields,Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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危险品化学品经营许可证（带存储）