丙酸氯倍他索, 糖皮质激素受体激动剂

Glucocorticoid Receptor Agonists
有货

库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
C409015-1ml
1ml 现货 Stock Image
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Compound libraries (12332)

基本描述

英文别名 CGP9555, CCl 4725 | (11β,​16β)​-21-​chloro-​9-​fluoro-​11-​hydroxy-​16-​methyl-​17-​(1-​oxopropoxy)​-​pregna-​1,​4-​diene-​3,​20-​dione
规格或纯度 Moligand™, 10mM in DMSO
英文名称 Clobetasol propionate
生化机理 丙酸氯倍他索(CGP9555,CCl 4725)是一种抗炎皮质类固醇,用于治疗各种皮肤病。
储存温度 -80℃储存
运输条件 超低温冰袋运输
作用类型 激动剂
作用机制 糖皮质激素受体激动剂
产品介绍


Information

Clobetasol propionate Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

产品属性

ALogP 3.958
hba_count 4
HBD Count 1
Rotatable Bond 5

关联靶点(人)

CYP3A4 Tclin 细胞色素P450 3A4(Cytochrome P450 3A4) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
NR3C1 Tclin 糖皮质激素受体(Glucocorticoid receptor) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CYP3A5 Tclin 细胞色素 P450 3A5(Cytochrome P450 3A5) (5 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

名称和识别符

分子类型 小分子
Canonical SMILES CCC(=O)OC1(C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CCl
分子量 466.97
Reaxy-Rn 37811597
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37811597&ln=

化学和物理性质

DMSO(mg / mL) Max Solubility 93
DMSO(mM) Max Solubility 199.16
Water(mg / mL) Max Solubility <1

安全和危险性(GHS)

Reaxy-Rn 37811597
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37811597&ln=

技术规格说明书

Concentration(Compounding value) 9-11(mmol/L)
Record the entire process by video Conform

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

此产品的引用文献

1. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang.  (2021)  One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters.  CHEMICAL ENGINEERING JOURNAL,  406  (126785).  [10.1016/j.cej.2020.126785]
2. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou.  (2018)  A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS.  TALANTA,  180  (358).  [PMID:29332823] [10.1016/j.talanta.2017.12.071]

参考文献

1. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang.  (2021)  One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters.  CHEMICAL ENGINEERING JOURNAL,  406  (126785).  [10.1016/j.cej.2020.126785]
2. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou.  (2018)  A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS.  TALANTA,  180  (358).  [PMID:29332823] [10.1016/j.talanta.2017.12.071]

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