计算溶液所需的质量、体积或浓度。
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
概述
Didanosine是一种逆转录酶抑制剂，IC50为0.49 μM。A potent anti-retroviral agent that acts by competing with natural dATP.
Information
Didanosine Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
In vitro
Didanosine induces cytoplasmic lipid droplet accumulations, increases lactate production and decreases activities of COX (complex IV) and SDH (part of complex II) in cultured human muscle cells. Didanosine is converted to its active moiety, dideoxyadenosine-5\'-triphosphate (ddATP), which inhibits HIV reverse transcriptase and terminates viral DNA growth in the target cell for HIV. Didanosine induces dose-dependent decreases in neurite number, length of the longest neurite in each neuron, and total neurite length per neuron in dissociated DRG cell cultures with 3 days treatment. Didanosine induces a neurite retraction or neurite loss in a dose-dependent manner in dissociated DRG neurons, suggesting that Didanosine may partially contribute to developing peripheral neuropathy. Didanosine potentiates the mutagenicity of Zidovudine in the thymidine kinase (TK) gene of cultured human TK6 lymphoblastoid cells. Didanosine combined with Zidovudine causes a significant increase in micronucleated PCEs and induces a significant increase in Tk mutants, which is associated with loss of the wild-type Tk+ allele. Didanosine depletes mitochondrial DNA (mtDNA) in cultured hepatocytes, this mtDNA depletion is associated with an increased in vitro production of lactate.
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥95%
规格
英文别名
2',3'-dideoxy-inosine
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Didanosine
生化机理
地达诺辛是一种逆转录酶抑制剂，其 IC50 值为 0.49 μM。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
EC号
614-994-4
分子类型
小分子
Isomeric SMILES
C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2N=CNC3=O
分子量
236.23
Beilstein号
3619529
Reaxy-Rn
24723407
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24723407&ln=
技术文档
高级数据
产品属性
| ALogP | -1.2 |
|---|
化学和物理性质
比旋光度
-28° (C=0.34,H2O)
熔点
182°C
安全和危险性（GHS）
信号词
警告
危险声明
H341: 怀疑引起遗传缺陷
RTECS
NM7460700
Merck Index
3098
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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危险品化学品经营许可证（带存储）