| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| E408574-1ml |
1ml |
现货  |
|
| 英文别名 | 2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Etodolac |
| 生化机理 | 依托度酸是一种非甾体抗炎药（NSAID），也是一种 COX 抑制剂，用于治疗炎症和疼痛。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 环氧化酶-2 抑制剂 |
| 产品介绍 |
Etodolac 是COX抑制剂，IC50为53.5 nM。 Information Etodolac Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain. Etodolac markedly inhibits ICl, vol activation by TNFα as well as subsequent apoptotic events such as apoptotic cell volume decrease (AVD) and elevation of caspase-3/7 activity in isolated rabbit articular chondrocytes. In vivo Etodolac attenuates paclitaxel-induced peripheral neuropathy by a COX-independent pathway in a mouse model of mechanical allodynia. Etodolac and other NSAIDs inhibits paw swelling and causes gastric mucosal lesions in adjuvant arthritic rats in a dose-dependent manner. Etodolac shows the highest UD(50) value and safety index among these NSAIDs in arthritic rats. Etodolac also shows the highest UD(50) value and safety index, except when its effects are assessed by acetic acid-induced writhing in normal rats. Etodolac dose-dependently inhibits the development of gastric cancer, and no cancer is detected at a dose of 30 mg/kg/day. Etodolac does not affect the extent of inflammatory cell infiltration or oxidative DNA damage, but it significantly inhibits mucosal cell proliferation and dose-dependently represses the development of intestinal metaplasia in the stomachs of Helicobacter pylori (Hp)-infected Mongolian gerbils (MGs). Etodolac alleviates heat-evoked hyperalgesia in the CCI rats and the increase in number of TRAP-positive multinucleated osteoclasts on the CCI-side is abrogated, however, it does not inhibit the decrease of bone mineral content (BMC) and bone mineral density (BMD) on the CCI-side. cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 3.723 |
|---|---|
| hba_count | 2 |
| HBD Count | 1 |
| Rotatable Bond | 4 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CCC1=CC=CC2=C1[NH]C3=C2CCOC3(CC)CC(O)=O |
| 分子量 | 287.35 |
| Reaxy-Rn | 928311 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=928311&ln= |
| DMSO(mg / mL) Max Solubility | 58 |
|---|---|
| DMSO(mM) Max Solubility | 201.84 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 928311 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=928311&ln= |
| Concentration(Compounding value) | 9-11（mmol/L） |
|---|---|
| Record the entire process by video | Conform |
| 1. Xiaoran Hu, Yanan Tian, Zidan Cao, Jiao Sha, Zibo Huang, Yu Li, Tao Li, Baozeng Ren. (2020) Solubility measurement, Hansen solubility parameter and thermodynamic modeling of etodolac in four binary solvents from 278.15 K to 323.15 K. JOURNAL OF MOLECULAR LIQUIDS, 318 (114155). [10.1016/j.molliq.2020.114155] |
| 2. Xiaoran Hu, Yi Gong, Zidan Cao, Zibo Huang, Jiao Sha, Yu Li, Tao Li, Baozeng Ren. (2020) Solubility, Hansen solubility parameter and thermodynamic properties of etodolac in twelve organic pure solvents at different temperatures. JOURNAL OF MOLECULAR LIQUIDS, 316 (113779). [10.1016/j.molliq.2020.113779] |
| 3. Yuhong Zhou, Qian Liang, Zhilun Zhang, Zhaodi Wang, Mingxian Huang. (2020) Chiral separations with crosslinked cellulose derivatives attached onto hybrid silica monolith particles via the thiol–ene click reaction. Analytical Methods, 12 (21): (2727-2734). [PMID:32930304] [10.1039/D0AY00772B] |
| 4. Lian Xu, Yan Xiao, Kun Yu, Hongshuo Pan, Jiayi Xu, Yiyun Guan, Mengke Wang, Xiangyu Xu, Hao Wang. (2025) Machine Learning-Assisted Chemical Tongues Based on Dual-channel Inclusion Complexes for Rapid Identification of Nonsteroidal Anti-inflammatory Drugs in Food. ACS Sensors, [PMID:39992799] [10.1021/acssensors.4c02806] |
| 1. Xiaoran Hu, Yanan Tian, Zidan Cao, Jiao Sha, Zibo Huang, Yu Li, Tao Li, Baozeng Ren. (2020) Solubility measurement, Hansen solubility parameter and thermodynamic modeling of etodolac in four binary solvents from 278.15 K to 323.15 K. JOURNAL OF MOLECULAR LIQUIDS, 318 (114155). [10.1016/j.molliq.2020.114155] |
| 2. Xiaoran Hu, Yi Gong, Zidan Cao, Zibo Huang, Jiao Sha, Yu Li, Tao Li, Baozeng Ren. (2020) Solubility, Hansen solubility parameter and thermodynamic properties of etodolac in twelve organic pure solvents at different temperatures. JOURNAL OF MOLECULAR LIQUIDS, 316 (113779). [10.1016/j.molliq.2020.113779] |
| 3. Yuhong Zhou, Qian Liang, Zhilun Zhang, Zhaodi Wang, Mingxian Huang. (2020) Chiral separations with crosslinked cellulose derivatives attached onto hybrid silica monolith particles via the thiol–ene click reaction. Analytical Methods, 12 (21): (2727-2734). [PMID:32930304] [10.1039/D0AY00772B] |
| 4. Lian Xu, Yan Xiao, Kun Yu, Hongshuo Pan, Jiayi Xu, Yiyun Guan, Mengke Wang, Xiangyu Xu, Hao Wang. (2025) Machine Learning-Assisted Chemical Tongues Based on Dual-channel Inclusion Complexes for Rapid Identification of Nonsteroidal Anti-inflammatory Drugs in Food. ACS Sensors, [PMID:39992799] [10.1021/acssensors.4c02806] |
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