溶于醇、丙酮、二氧六环、苯、氯仿、吡啶及氢氧化碱溶液，微溶于醚和植物油，几乎不溶于水,水中溶解度:0.03 g/L。 Estrone is an estrogenic hormone. Target: Estrogen Receptor/ERR Estrone (E1) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estrogen in postmenopausal women.该品是1号避孕药用的激素类药炔雌醇的中间体。

Information

Estrone is an estrogenic hormone.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

规格

规格或纯度

Moligand™, 10mM in DMSO

英文名称

Estrone

生化机理

雌酮是一种雌激素。

储存条件

-80℃储存

运输条件

特低温运输

名称和识别符

EC号

200-164-5

分子类型

小分子

Isomeric SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)O

分子量

270.37

Beilstein号

1915077

Reaxy-Rn

1915075

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1915075&ln=

高级数据

关联靶点（人）

ESR1 Tclin 雌激素受体(Estrogen receptor) (8 活性数据)

点击查看靶蛋白信息： ESR1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

ESR2 Tclin 雌激素受体β(Estrogen receptor beta) (7 活性数据)

点击查看靶蛋白信息： ESR2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

HSD17B1 Tchem 雌二醇 17-β-脱氢酶 1(Estradiol 17-beta-dehydrogenase 1) (6 活性数据)

点击查看靶蛋白信息： HSD17B1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

SHBG Tchem 性激素结合球蛋白(Sex hormone-binding globulin) (1 活性数据)

点击查看靶蛋白信息： SHBG

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

化学和物理性质

溶解性

Solubility (25°C) In vitro DMSO: 31 mg/mL (198.37 mM); Water: 31 mg/mL (198.37 mM); Ethanol: 31 mg/mL (198.37 mM);

比旋光度

165 ° (C=1, Dioxane)

熔点

258-260°C

安全和危险性（GHS）

WGK Germany

RTECS

KG8575000

Merck Index

3708

个人防护装备

Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

后期氟化工具箱：给候选分子做“微创升级”：四类“氟旋钮”→ 亲电/亲核两大路线 → ¹⁸F-PET 示踪分线 → 选型导航与代表产品清单

目录：技术文章

探索主题:

氟药物研究

Late-Stage Fluorination Toolbox: “Minimally Invasive Upgrades” for Lead Candidates： Four “Fluorine Knobs” → Two major routes (electrophilic vs nucleophilic) → An ¹⁸F-PET tracer branch → Selection navigation & representative product list

目录：技术文章

探索主题:

Drug discovery Fluorine