叶酸 - 聚乙二醇活性酯(Folic acid PEG NHS),又称叶酸 PEG NHS,是 Nanocs 公司生产的氨基反应型叶酸聚乙二醇衍生物之一。NHS(琥珀酰亚胺酯)可在弱碱性条件下与伯氨基快速、高效发生反应。通过该反应,可将叶酸配体偶联至蛋白质、抗体、多肽或微粒表面。聚乙二醇化叶酸具备良好的水溶性与生物活性。经叶酸修饰的基底材料已广泛应用于靶向药物递送、生物成像及生物检测技术开发领域。
Folic acid PEG NHS, also called Folate PEG NHS, is one of Nanocs amine reactive folic acid PEG derivatives. NHS (succinimidyl ester) reacts with primary amine groups in alkaline conditions quickly and efficiently. This reaction allows attachment of folic acid ligand to proteins, antibodies, peptides or particle surfaces. Pegylated folic acid has relatively good water solubility and bioactivity. Folic acid functionalized substrates have been used for targeted drug delivery, imaging, and bioassay development.