5-Fluoro-2′-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells. Floxuridine is effective for treating liver cancer and eliminating virulence of Staphylococcus aureus. Dipeptide prodrμgs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity. Floxuridine is effective on solid tumours and advanced stage cancers.5-Fluoro-2′-deoxyuridine has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures.

Information

Floxuridine (NSC 27640) Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(A
In vitro

Floxuridine exhibits higher affinity for PEPT1 than the corresponding 5\'-O-mono amino acid ester prodrugs. Floxuridine combined with Leucovorin results in synergistic inhibitory effects on growth of human T-lymphoblast leukemia cells. Floxuridine significantly inhibits the uptake of both [(3)H]-inosine and [(3)H]-adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibits markedly decreased inhibition potency (10-30% of control). Floxuridine inhibits cell proliferation by more than 50% relative to the untreated control cells at 36 days, the cell numbers still increases fourfold compared with the initial cell density. Floxuridine results in prolonged effects on the proliferation of human Tenon\'s capsule fibroblasts in vitro. Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

规格

英文别名

Deoxyfluorouridine, FUDR | 5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

规格或纯度

Moligand™, 10mM in DMSO

英文名称

5-Fluoro-2′-deoxyuridine(FUDR)

生化机理

氟尿嘧啶（NSC 27640，脱氧氟尿嘧啶，FUDR）是一种在体内迅速分解为 5-氟尿嘧啶的原药。氟尿嘧啶用于治疗各种癌症，尤其是肝脏转移癌。氟尿嘧啶可抑制聚(ADP-核糖)聚合酶，诱导 DNA 损伤和细胞凋亡。Floxuridine 对 HSV 和 CMV 有抗病毒作用。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

抑制剂

作用机制

胸腺嘧啶酸合成酶抑制剂

名称和识别符

EC号

200-072-5

分子类型

小分子

Isomeric SMILES

C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O

UN Number

1760

Packing Group

分子量

246.19

Reaxy-Rn

24714617

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24714617&ln=

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

产品属性

ALogP	-1.2

化学和物理性质

比旋光度

38 ° (C=1, H2O)

熔点

148°C

安全和危险性（GHS）

象形图

GHS06, GHS08

信号词

Danger

危险声明

H301: 吞咽会中毒

H341: 怀疑引起遗传缺陷

预防措施声明

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P281: 根据需要使用个人防护设备。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P330: 漱口

P203: 使用前，获取、阅读并遵守所有安全说明。

P301+P316: 如果吞咽：立即寻求紧急医疗救助。

P318: 如果暴露或担心，请就医。

RTECS

YU7525000

Class

Merck Index

4112

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

肿瘤细胞中核苷酸的合成

目录：技术文章

探索主题:

核苷酸糖酵解 5-磷酸核糖 TCA循环

Nucleotide Synthesis in Cancer Cells

目录：技术文章

探索主题:

nucleotide Glycolysis Ribose 5-phosphate TCA cycle

嘧啶科研选型指南：结构特性、典型应用与试剂/构建块分类导航（表1–表5）

目录：技术文章

探索主题:

嘧啶嘧啶碱基

Pyrimidine Research Selection Guide: Structural Features, Typical Applications, and a Reagent/Building-Block Classification Navigator (Tables 1–5)

目录：技术文章

探索主题:

Pyrimidine Pyrimidine base

认识有机氟杂环化合物：结构调控、应用场景、科研选型与产品导航（表1–表5）

目录：技术文章

探索主题:

氟有机氟杂环化合物

Understanding Organofluorine Heterocycles: Structure Tuning, Applications, Research Selection, and Product Navigation (Tables 1-5)

目录：技术文章

探索主题:

Fluorine Organofluorine heterocycles

核苷代谢相关酶在药物响应与疾病生物学中的功能体系

目录：技术文章

探索主题:

补救合成代谢重编程核苷代谢脱氧胞苷激酶胞苷脱氨酶腺苷激酶嘌呤核苷磷酸化酶胸苷激酶药物响应疾病生物学

Functional Systems of Nucleoside Metabolism-Related Enzymes in Drug Response and Disease Biology

目录：技术文章

探索主题:

Salvage synthesis Metabolic Reprogramming Nucleoside Metabolism Deoxycytidine Kinase Cytidine Deaminase Adenosine Kinase Purine Nucleoside Phosphorylase Thymidine Kinase Drug Response Disease Biology

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索