Regulation of Glycolytic Rate-Limiting Enzymes: Functional Comparison of Hexokinase, Phosphofructokinase, and Pyruvate Kinase
Glycolytic rate-limiting enzymes determine the key nodes from glucose uptake and flux commitment to pyruvate formation. Hexokinase, phosphofructokinase, and pyruvate kinase respectively control early substrate trapping, irreversible mid-pathway flux commitment, and terminal ATP generation in ...
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