autophagy-lysosome system

AUTAC or AUTOTAC? Mechanistic Differences Between First- and Second-Generation Autophagy-Targeting Degradation Technologies

Targeted protein degradation is expanding from the ubiquitin-proteasome system to the autophagy-lysosome system. AUTAC, AUTOTAC, and ATTEC can all exploit autophagy to eliminate specific targets, but they differ in cargo recognition and autophagy-recruitment mechanisms. First- and ...