Necrosis by Sodium Overload (NECSO): TRPM4-Mediated Na⁺ Overload, ATP Depletion, and Experimental Validation
Necrosis by sodium overload (NECSO) is a form of necrotic cell death caused by sustained activation of transient receptor potential melastatin 4 (TRPM4). It is characterized by massive Na⁺ influx, membrane depolarization, osmotic imbalance, and cellular swelling and is accompanied by disruption ...
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