In amide bond formation, Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate, commonly marketed as OxymaPure] is usually classified as a coupling additive used to reduce racemization. That definition captures only part of its role. Representative studies published in 2009 clearly established Oxyma as a ...
A highly effective nickel-catalyzed process enables the direct reductive cross-coupling of equimolar quantities of alkyl and aryl halides in the presence of manganese, demonstrating excellent yield, functional group compatibility, and operational simplicity. This transformation bypasses the ...