ethyl 2-cyano-2-(hydroxyimino)acetate

Experimental Judgment in Oxyma Coupling Systems: Coupling Efficiency, Racemization Control, and the HCN Risk in DIC-Based Systems

In amide bond formation, Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate, commonly marketed as OxymaPure] is usually classified as a coupling additive used to reduce racemization. That definition captures only part of its role. Representative studies published in 2009 clearly established Oxyma as a ...