受体酪氨酸激酶异常信号在肿瘤发生、精准分型与靶向治疗中的作用
受体酪氨酸激酶（receptor tyrosine kinase，RTK）通过酪氨酸磷酸化调控细胞增殖、存活、迁移和分化。RTK突变、扩增、融合或异常表达可持续激活MAPK、PI3K/AKT、STAT和PLC等信号通路，推动肿瘤发生并影响分子分型、靶向治疗及耐药。
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EGFR
用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。
11 项资源 · 实验方案、常见问题与文章
Role of Aberrant Receptor Tyrosine Kinase Signaling in Tumorigenesis, Precision Classification, and Targeted Therapy
Receptor tyrosine kinases (RTKs) regulate cell proliferation, survival, migration, and differentiation through tyrosine phosphorylation. RTK mutations, amplifications, fusions, or abnormal expression can continuously activate MAPK, PI3K/AKT, STAT, PLC, and other signaling pathways, thereby ...
非小细胞肺癌的分子分型、驱动靶点与耐药机制
非小细胞肺癌具有显著的组织学和分子异质性。EGFR、ALK、ROS1、KRAS、BRAF、RET、MET和HER2等异常可持续激活肿瘤细胞增殖与存活信号，并形成具有不同生物学特征和药物敏感性的分子亚型。
Molecular Classification, Oncogenic Drivers, and Resistance Mechanisms of Non-Small Cell Lung Cancer
Non-small cell lung cancer exhibits substantial histological and molecular heterogeneity. Alterations involving EGFR, ALK, ROS1, KRAS, BRAF, RET, MET, HER2, and other oncogenic drivers can continuously activate tumor-cell proliferation and survival signaling and generate molecular subtypes with ...
Role of the HER3 Signaling Network in Tumor Progression, Therapeutic Resistance, and Targeted Intervention
HER3 strengthens PI3K/AKT survival signaling by forming heterodimers with receptors such as HER2 and EGFR and contributes to bypass compensation, maintenance of drug resistance, and tumor progression under multiple therapeutic pressures.
HER3信号网络在肿瘤进展、治疗耐药与靶向干预中的作用
HER3通过与HER2、EGFR等受体形成异源二聚体，强化PI3K/AKT生存信号，并在多种治疗压力下参与旁路补偿、耐药维持和肿瘤进展。
蛋白酪氨酸激酶/RTK信号转导机制与疾病研究
蛋白酪氨酸激酶（protein-tyrosine kinases，PTKs）可将ATP的γ-磷酸基团转移至蛋白底物的酪氨酸残基，参与细胞增殖、分化、迁移、代谢和存活调控。PTKs主要包括受体型蛋白酪氨酸激酶（receptor tyrosine kinases，RTKs）和非受体型蛋白酪氨酸激酶（nonreceptor tyrosine ...
Protein Tyrosine Kinase/RTK Signal Transduction Mechanisms and Disease Research
Protein tyrosine kinases (PTKs) transfer the γ-phosphate group of ATP to tyrosine residues on protein substrates and participate in the regulation of cell proliferation, differentiation, migration, metabolism, and survival. PTKs mainly include receptor tyrosine kinases (RTKs) and nonreceptor ...
Structural Features, Activation Logic, and Signaling Output of the ErbB Family Pathway
The ErbB family pathway is a major module within receptor tyrosine kinase networks. Its key feature is not activation of a single receptor in isolation, but rather the coordinated determination of biological outcomes such as cell proliferation, survival, differentiation, and migration through ...
ErbB家族通路的结构特征、激活逻辑与信号输出
ErbB家族通路是受体酪氨酸激酶网络中的重要模块，其关键不在于单一受体被激活，而在于配体识别、受体二聚化、胞内酪氨酸位点磷酸化以及多条下游信号轴共同决定细胞增殖、存活、分化和迁移等生物学结果。
Erucin
Erucin is an isothiocyanate compound found in cruciferous vegetables such as broccoli and arugula. Isothiocyanates are phytochemicals with diverse bioactivities, among which anticancer effects are particularly notable. Other common isothiocyanates include sulforaphane and 3-methylsulfinylpropyl ...
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常与免疫学实验一起研究的技术。
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