The peripheral nervous system (PNS) participates in local immune regulation through sensory nerves, autonomic nerves, Schwann cells, and satellite glial cells. Immune cells and the cytokines, chemokines, and inflammatory mediators they release can also reciprocally affect neuronal excitability, ...
Nerve growth factor (NGF) is a prototypical member of the neurotrophin family. Through interactions with the high-affinity receptor TrkA (NTRK1) and the low-affinity receptor p75NTR (NGFR), NGF regulates neuronal survival, axonal growth, synaptic plasticity, and processes related to injury repair.