A pyridine ring contains several C–H bonds with relatively similar properties. Nevertheless, deprotonative metalation using sterically hindered metal amide bases often exhibits high regioselectivity, and changing the metalation system can markedly shift the site of reaction.
The core of this study is the conversion of nitroarenes into pyridine frameworks through photochemically induced nitrene formation, aromatic-ring rearrangement, and selective carbon deletion. In essence, this transformation belongs to aromatic skeletal editing: rather than installing functional ...
If you’ve ever searched the literature in medicinal chemistry, agrochemical R&D, materials and catalysis, or analytical testing, you’ll quickly notice one fact: the “pyridine ring” appears with striking frequency. The reason is not mysterious—pyridine is both an important basic chemical (it can ...