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Antibody–drug conjugates (ADCs) use tumor cell-surface antigens to achieve antibody recognition and payload delivery. HER2, TROP2, Nectin-4, FRα, and c-Met have received substantial clinical validation, while HER3, B7-H3, CLDN18.2, and DLL3 continue to enter ADC development pipelines. The ...
抗体偶联药物（antibody–drug ...
HER3通过与HER2、EGFR等受体形成异源二聚体，强化PI3K/AKT生存信号，并在多种治疗压力下参与旁路补偿、耐药维持和肿瘤进展。
HER3 strengthens PI3K/AKT survival signaling by forming heterodimers with receptors such as HER2 and EGFR and contributes to bypass compensation, maintenance of drug resistance, and tumor progression under multiple therapeutic pressures.
The ErbB family pathway is a major module within receptor tyrosine kinase networks. Its key feature is not activation of a single receptor in isolation, but rather the coordinated determination of biological outcomes such as cell proliferation, survival, differentiation, and migration through ...
ErbB家族通路是受体酪氨酸激酶网络中的重要模块，其关键不在于单一受体被激活，而在于配体识别、受体二聚化、胞内酪氨酸位点磷酸化以及多条下游信号轴共同决定细胞增殖、存活、分化和迁移等生物学结果。
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危险品化学品经营许可证（带存储）