计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
提供 ≥98%(HPLC) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
室温。常规运输 。请查阅批次 COA 获取详细规格。
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
在色谱分析、有机合成和交叉偶联反应领域已被 11 篇同行评审文献引用。
Product Application:
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.
分类树(Taxonomy Tree)
| 界(kingdom) | 有机化合物 |
|---|---|
| 超类(Superclass) | 有机杂环化合物 |
| 类(Class) | 二氮杂萘 |
| 亚类(Subclass) | 苯二嗪类 |
| 中间层级节点(Intermediate Tree Nodes) | 暂无 |
| 直接上位类(Direct Parent) | 喹唑啉 |
| 其他上位类(Alternative Parents) | 羟基嘧啶 苯类化合物 杂芳族化合物 氮杂环化合物 有机光子化合物 有机氧化合物 有机氮化合物 碳氢化合物衍生物 |
| 分子骨架(Molecular Framework) | 芳香族杂多环化合物 |
| 取代基(Substituents) | 芳香族杂多环化合物 - 氮杂环 - 苯基化合物 - 杂芳香族化合物 - 烃衍生物 - 羟基嘧啶 - 有机硝基化合物 - 有机氧化合物 - 有机氮化合物 - 有机氧化合物 - 有机氮化合物 - 嘧啶 - 萘啶 |
| 描述(Description) | 该化合物属于喹唑啉类有机化合物。这类化合物含有喹唑啉结构单元,由两个共环的六元芳环组成——即苯环与嘧啶环。 |
| 外部描述符(External Descriptors) | 暂无 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
H302: 吞食有害
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
H335: 可能引起呼吸道刺激
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P270: 使用本产品时,请勿进食、饮水或吸烟。
P271: 仅在室外或通风良好的地方使用。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理(请参阅此标签上的...)。
P330: 漱口
P302+P352: 如皮肤沾染:用水充分清洗。
P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。
P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。
P405: 密闭存放
P403+P233: 存放在通风良好的地方。保持容器密闭。
P501: 将内容物/容器处理到。。。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P301+P317: 如果被吞咽:请寻求医疗帮助。
P337+P317: 如果眼睛刺激持续:寻求医疗帮助。
P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。
P319: 如果你感到不适,请寻求医疗帮助。
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | H157172 | |
| 分析证书 | H157172 | |
| 分析证书 | H157172 | |
| 分析证书 | H157172 | |
| 分析证书 | H157172 | |
| 分析证书 | H157172 | |
| 分析证书 | H157172 | |
| 分析证书 | H157172 | |
| 分析证书 | H157172 | |
| 分析证书 | H157172 |
| 1. Tang Hongjie, Liu Yingzhu, Xu Haotian, Wang Fenghui, Xie Cancan, Zhang Huajiang, Jiang Longwei. (2023) Preparation and Characterization of Quercetin/Cyclodextrin/Carbon Quantum Dot Nanocomplexes and Evaluation of their Stability and In Vitro Digestive Properties. Food Biophysics, [10.1007/s11483-023-09821-7] |
| 2. Hanxun Yue, Xuan Zhao, Qin Yong, Min Shi, Xiaofeng Jiang, Yating Zhang, Xian Yu. (2023) Self-assembly of Hyaluronic Acid-Cu-Quercetin flavonoid nanoparticles: synergistic chemotherapy to target tumors. PeerJ, [PMID:37663303] [10.7717/peerj.15942] |
| 3. Zhiqi Zhai, Yue Fu, Xinyue Zhang, Yi Zhang, Chao Zhou, Xiaojia Huang, Linhong Deng. (2023) Liposomes loaded with quercetin for resolution of lung inflammation in a lipopolysaccharide-induced mouse model of sepsis. Biomedical Materials, 18 (3): (035004). [PMID:36863020] [10.1088/1748-605X/acc0bc] |
| 4. Fangping Liang, Wurong Li, Mingao Li, Xican Li, Jianfeng He, Quanzhou Wu. (2023) Kaempferol molecularly imprinted polymers: preparation, characterization and application to the separation of kaempferol from ginkgo leaves. POLYMER INTERNATIONAL, 72 (6): (586-596). [10.1002/pi.6511] |
| 5. Ziqian Xu, Yihui Xie, Jun Song, Juntao Huang, Weimin Shi. (2022) Mechanism of Action of a Chinese Herbal Compound Containing Quercetin, Luteolin, and Kaempferol in the Treatment of Vitiligo Based on Network Pharmacology and Experimental Verification. Evidence-based Complementary and Alternative Medicine, [PMID:36569347] [10.1155/2022/7197533] |
| 6. Tian Rui, Wang Hui, Xiao Yi, Hu Pengyue, Du Ruofei, Shi Xiufeng, Wang Zhengtao, Xie Yan. (2020) Fabrication of Nanosuspensions to Improve the Oral Bioavailability of Total Flavones from Hippophae rhamnoides L. and their Comparison with an Inclusion Complex. AAPS PHARMSCITECH, 21 (7): (1-14). [PMID:32875458] [10.1208/s12249-020-01788-9] |
| 7. Qin Tang, Fangling Ji, Jingyun Wang, Lianying Guo, Yachen Li, Yongming Bao. (2017) Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:28822757] [10.1016/j.ejps.2017.08.013] |
| 8. Jing Li, Jun Zhang, Yiyue Wang, Xiao Liang, Zaitongguli Wusiman, Yunzhi Yin, Qi Shen. (2017) Synergistic inhibition of migration and invasion of breast cancer cells by dual docetaxel/quercetin-loaded nanoparticles via Akt/MMP-9 pathway. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:28336457] [10.1016/j.ijpharm.2017.03.040] |
| 9. Zhixian Liang, Haiyun Zhai, Zuanguang Chen, Shiqiao Wang, Haihang Wang, Shumei Wang. (2017) A sensitive electrochemical sensor for flavonoids based on a multi-walled carbon paste electrode modified by cetyltrimethyl ammonium bromide-carboxylic multi-walled carbon nanotubes. SENSORS AND ACTUATORS B-CHEMICAL, [10.1016/j.snb.2016.12.108] |
| 10. Xiaoyu Jia, Kaiting He, Ling Cai, Yuhui Liu, Henghui Li, Xiaoxiao Dong, Min He, Li Zhang, Guannan Le, Shoulin Wang, Jin Chen. (2025) Coaxially fabricated electrospinning near-infrared light-responsive nanofibrous membranes for combating drug-resistant bacteria. JOURNAL OF HAZARDOUS MATERIALS, [PMID:40199072] [10.1016/j.jhazmat.2025.138106] |
| 11. Haibo Liu, Zhongyi Sun, Mengting Yin, Jing Ru, Xiaohao Liu, Ziyan Chen, Yating Liu, Wang Sun, Longpo Zheng, Xinyu Zhao, Feng Chen. (2025) Polyphenol-Modified Mg−Zn Layered Hydroxide-Contained Microneedle Patch Enhance Mucosal Repair by Remolding Diabetic Oral Microenvironment. Advanced Healthcare Materials, [PMID:39930773] [10.1002/adhm.202403883] |