C1729013计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™,分析标准品 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,避光,干燥。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 28 篇同行评审文献引用。
概述
对光敏感，易吸潮可溶性鸟苷酸环化酶（guanylyl cyclase）激活剂。具有抗肿瘤活性
规格
别名
2',4,4'-三羟基查尔酮
英文别名
SMR000112969 | EU-0100681 | NCGC00261366-01 | SR-01000075499 | (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one | A845551 | CHEBI:94010 | Isoliquiritigenin, powder | 2'',4'',4-trihydroxychalcone | 2'',4,4''-trihydroxychalcone | 2',4',4-Trihy
规格或纯度
分析标准品, Moligand™
英文名称
Isoliquiritigenin
生化机理
抗氧化剂和抗血管生成剂。减少从LPS刺激的巨噬细胞释放NO。抑制VEGF诱导的增殖。抑制新血管生成。抑制VEGF / VEGFR-2信号转导。在体内显示出心脏保护作用，抗缺血作用。
储存条件
2-8°C储存,避光,干燥
运输条件
低温运输
备注
如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
名称和识别符
PubChem SID
EC号
677-489-8
分子类型
小分子
IUPAC Name
(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
INCHI
1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
InChi Key
DXDRHHKMWQZJHT-FPYGCLRLSA-N
Smiles
C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O
Isomeric SMILES
C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O
分子量
256.25
Reaxy-Rn
1914295
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1914295&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
-
界（kingdom)
有机化合物
-
超类（Superclass)
苯丙素类和聚酮类
-
类（Class)
线性1,3-二芳基丙烷类化合物
- 亚类（Subclass） 查尔酮和二氢查尔酮
-
类（Class)
线性1,3-二芳基丙烷类化合物
-
超类（Superclass)
苯丙素类和聚酮类
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 苯丙素类和聚酮类 |
| 类（Class) | 线性1,3-二芳基丙烷类化合物 |
| 亚类（Subclass） | 查尔酮和二氢查尔酮 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 2'-羟基查尔酮 |
| 其他上位类（Alternative Parents） | 肉桂基酚 羟基肉桂酸及其衍生物 苯乙烯 间苯二酚 苯甲酰衍生物 芳基酮 1-羟基-4-未取代苯类化合物 1-羟基-2-未取代苯类化合物 乙烯基酸 烯酮类 丙烯酰化合物 有机氧化物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 芳香族同单环化合物 |
| 取代基（Substituents） | 1-羟基-2-未取代苯环化合物 - 1-羟基-4-未取代苯环化合物 - 2'-羟基查尔酮 - 丙烯酰基基团 - α,β-不饱和酮 - 芳香族同单环化合物 - 芳基溴化物 - 苯基化合物 - 苯甲酰 - 肉桂酚 - 酮 - 烃衍生物 - 羟基肉桂酸或其衍生物 - 酮 - 单环苯基基团 - 有机氧化物 - 有机氧化合物 - 有机氧化合物 - 苯酚 - 间苯二酚 - 苯乙烯 - 乙烯基羧酸 |
| 描述（Description） | 该化合物属于有机化合物中的2'-羟基查酮类。这类化合物具有查酮骨架，其2'-位带有羟基。 |
| 外部描述符（External Descriptors） | Chalcones and dihydrochalcones |
三维结构
交互式化学结构模型
关联靶点（人）
HSD17B2
Tchem
雌二醇 17-β-脱氢酶 2(Estradiol 17-beta-dehydrogenase 2)
(1 活性数据)
AKR1B1
Tclin
醛糖还原酶(Aldose reductase)
(1 活性数据)
EGFR
Tclin
Epidermal growth factor receptor erbB1
(33727 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
ALOX5
Tclin
Arachidonate 5-lipoxygenase
(6568 活性数据)
TOP1
Tclin
DNA topoisomerase I
(7553 活性数据)
VDR
Tclin
Vitamin D receptor
(26531 活性数据)
CYP19A1
Tclin
Cytochrome P450 19A1
(6099 活性数据)
TYR
Tclin
Tyrosinase
(717 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
MAOB
Tclin
Monoamine oxidase B
(8835 活性数据)
PPARG
Tclin
Peroxisome proliferator-activated receptor gamma
(15191 活性数据)
XDH
Tclin
Xanthine dehydrogenase
(1038 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
ESR2
Tclin
Estrogen receptor beta
(9272 活性数据)
KIT
Tclin
Stem cell growth factor receptor
(10667 活性数据)
AKR1B1
Tclin
Aldose reductase
(1404 活性数据)
JUN
Tchem
Proto-oncogene c-JUN
(434 活性数据)
CYP1B1
Tchem
Cytochrome P450 1B1
(1148 活性数据)
FGFR2
Tclin
Fibroblast growth factor receptor 2
(3405 活性数据)
FGFR1
Tclin
Fibroblast growth factor receptor 1
(9149 活性数据)
SRC
Tclin
Tyrosine-protein kinase SRC
(10310 活性数据)
CHRNA7
Tchem
Neuronal acetylcholine receptor protein alpha-7 subunit
(3524 活性数据)
APP
Tclin
Amyloid-beta A4 protein
(8510 活性数据)
GBA1
Tclin
Beta-glucocerebrosidase
(14647 活性数据)
KDR
Tclin
Vascular endothelial growth factor receptor 2
(20924 活性数据)
MMP3
Tchem
Matrix metalloproteinase 3
(3433 活性数据)
CYP1A1
Tchem
Cytochrome P450 1A1
(1169 活性数据)
MTOR
Tclin
Serine/threonine-protein kinase mTOR
(13850 活性数据)
MET
Tclin
Hepatocyte growth factor receptor
(10718 活性数据)
HSD17B1
Tchem
Estradiol 17-beta-dehydrogenase 1
(2224 活性数据)
GLP1R
Tclin
Glucagon-like peptide 1 receptor
(111429 活性数据)
BACE1
Tchem
Beta-secretase 1
(15641 活性数据)
MMP7
Tchem
Matrix metalloproteinase 7
(1073 活性数据)
PIN1
Tchem
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(36611 活性数据)
CYP2C9
Tchem
Cytochrome P450 2C9
(32119 活性数据)
CYP2C19
Tchem
Cytochrome P450 2C19
(29246 活性数据)
MMP1
Tchem
Matrix metalloproteinase-1
(7046 活性数据)
HSD17B2
Tchem
Estradiol 17-beta-dehydrogenase 2
(1671 活性数据)
CYP3A4
Tclin
Cytochrome P450 3A4
(53859 活性数据)
TP53
Tchem
Cellular tumor antigen p53
(48468 活性数据)
HT-1080
(3966 活性数据)
K562
(73714 活性数据)
LoVo
(4724 活性数据)
MCF-10A
(2462 活性数据)
MCF7
(126967 活性数据)
MT4
(17854 活性数据)
PANC-1
(6144 活性数据)
PC-3
(62116 活性数据)
SH-SY5Y
(11521 活性数据)
SiHa
(2051 活性数据)
关联靶点（其它种属）
NA
Neuraminidase (1107 活性数据)
ampC
Beta-lactamase AmpC (62480 活性数据)
Mmp13
Matrix metalloproteinase 13 (19 活性数据)
Mmp2
Matrix metalloproteinase-2 (12 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Ptpn1
Protein-tyrosine phosphatase 1B (270 活性数据)
Cryz
Quinone oxidoreductase (288 活性数据)
Mmp9
Matrix metalloproteinase 9 (38 活性数据)
pol
Human immunodeficiency virus type 1 integrase (9041 活性数据)
Streptococcus sobrinus (228 活性数据)
Pseudomonas aeruginosa (123386 活性数据)
Porphyromonas gingivalis (651 活性数据)
Staphylococcus aureus (210822 活性数据)
Staphylococcus epidermidis (22802 活性数据)
Staphylococcus haemolyticus (1695 活性数据)
Escherichia coli (133304 活性数据)
Fusobacterium nucleatum (386 活性数据)
Streptococcus mutans (2687 活性数据)
Bacillus subtilis (32866 活性数据)
Saccharomyces cerevisiae (19171 活性数据)
Bacillus cereus (7522 活性数据)
Trypanosoma brucei brucei (13300 活性数据)
Plasmodium falciparum (966862 活性数据)
Leishmania donovani (89745 活性数据)
Mus musculus (284745 活性数据)
Rattus norvegicus (775804 活性数据)
Hepatitis C virus (23859 活性数据)
Influenza A virus (11224 活性数据)
3T3-L1 (3664 活性数据)
CHO (4503 活性数据)
MDCK (10148 活性数据)
PC-12 (7051 活性数据)
RAW264.7 (28094 活性数据)
Vero (26788 活性数据)
BV-2 (3710 活性数据)
NIH3T3 (5395 活性数据)
HT-22 (3261 活性数据)
C2C12 (756 活性数据)
CT26 (928 活性数据)
Npsr1
Neuropeptide S receptor (260 活性数据)
Luciferin 4-monooxygenase (66902 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
nanH
Sialidase (337 活性数据)
pfk
6-phospho-1-fructokinase (7870 活性数据)
Txnrd1
Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
Pectobacterium carotovorum (295 活性数据)
Prevotella intermedia (369 活性数据)
Mapt
Microtubule-associated protein tau (6 活性数据)
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
Rorc
Nuclear receptor ROR-gamma (89407 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
密度
1.384
敏感性
易吸潮
熔点
198 °C
分子量
256.250 g/mol
XLogP3
3.200
氢键供体数Hydrogen Bond Donor Count
3
氢键受体数Hydrogen Bond Acceptor Count
4
可旋转键计数Rotatable Bond Count
3
精确质量Exact Mass
256.074 Da
单同位素质量Monoisotopic Mass
256.074 Da
拓扑极表面积Topological Polar Surface Area
77.800 Ų
重原子数Heavy Atom Count
19
形式电荷Formal Charge
0
复杂度Complexity
331.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
1
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
1
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
H335: 可能引起呼吸道刺激
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P271: 仅在室外或通风良好的地方使用。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理（请参阅此标签上的...）。
P302+P352: 如皮肤沾染：用水充分清洗。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P405: 密闭存放
P403+P233: 存放在通风良好的地方。保持容器密闭。
P501: 将内容物/容器处理到。。。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
3
RTECS
FL7080000
个人防护装备
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
质检证书（CoA,COO,BSE/TSE 和分析图谱)
技术文档和文章
组蛋白去乙酰化酶抑制剂
目录： 技术文章
VEGFR Inhibitors
目录： 技术文章
此产品的引用文献
引用文献
| 1. Liangwan Wei, Zhe Wang, Yindi Chu, Kun Cai, Wei Li, Piying Huang, Youcai Qin, Dailin Liu, Xiaocui Zhuang, Mingquan Guo, Xinbo Song, Enguo Fan. (2023) Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:37245294] [10.1016/j.bbrc.2023.05.083] |
| 2. Zhang Xiuying, Chen Qilei, Zhao Jia, Zhao Wei, Fan Ni, Wang Yu, Chen Hubiao, Rong Jianhui. (2023) A four-compound remedy AGILe protected H9c2 cardiomyocytes against oxygen glucose deprivation via targeting the TNF-α/NF-κB pathway: Implications for the therapy of myocardial infarction. Frontiers in Pharmacology, [PMID:36713834] [10.3389/fphar.2023.1050970] |
| 3. Yufang Su, Lei Fang, Kaili Zhong, Ting Wang, Mingjie Bao, Ting Zhou, Yuan Zhu. (2023) Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos. ENVIRONMENTAL TOXICOLOGY, 38 (3): (654-665). [PMID:36617718] [10.1002/tox.23715] |
| 4. Jianman Wang, Hongjin Chen, Tao Guo, Ping Yue, Tianbao Qian, Xiangyu Zeng, Yali Luo, Jiangmin Li, Lijing Teng, Qingyu Liu, Liang Hong, Zijiang Yu, Zuquan Hu. (2022) Isoliquiritigenin Nanoemulsion Preparation by Combined Sonication and Phase-Inversion Composition Method: In Vitro Anticancer Activities. Bioengineering-Basel, 9 (8): (382). [PMID:36004907] [10.3390/bioengineering9080382] |
| 5. Xiangrong Li, Hongyi Liu, Zhenhua Yang, Hanxiao Duan, Ziyang Wang, Zeqing Cheng, Zhizhi Song, Xinzhe Wu. (2021) Study on the interaction of hyaluronidase with certain flavonoids. JOURNAL OF MOLECULAR STRUCTURE, [10.1016/j.molstruc.2021.130686] |
| 6. Li-Juan Wang, Lin He, Lu Hao, Hong-Lei Guo, Xiang-Peng Zeng, Ya-Wei Bi, Guo-Tao Lu, Zhao-Shen Li, Liang-Hao Hu. (2020) Isoliquiritigenin ameliorates caerulein-induced chronic pancreatitis by inhibiting the activation of PSCs and pancreatic infiltration of macrophages. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 24 (17): (9667-9681). [PMID:32678498] [10.1111/jcmm.15498] |
| 7. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355] |
| 8. Zhang Man, Wu Yan-Qing, Xie Ling, Wu Jiang, Xu Ke, Xiao Jian, Chen Da-Qing. (2018) Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling. Frontiers in Pharmacology, [PMID:30174606] [10.3389/fphar.2018.00936] |
| 9. Jie-hua Shi, Jing Wang, Ying-yao Zhu, Jun Chen. (2013) Characterization of interaction between isoliquiritigenin and bovine serum albumin: Spectroscopic and molecular docking methods. JOURNAL OF LUMINESCENCE, [10.1016/j.jlumin.2013.08.042] |
| 10. Sisi Ke, Ningrui Wang, Xingyu Chen, Jiangwei Tian, Jiwei Li, Boyang Yu. (2025) A Label-Free Colorimetric Aptasensor for Flavokavain B Detection. SENSORS, 25 (2): (569). [PMID:39860936] [10.3390/s25020569] |
| 11. Tian-Xiu Qiu, Lei Liu, Xu Zhang, Yang Hu, Jiong Chen. (2024) Antiviral activity of isoliquiritigenin against SVCV in aquaculture: A dual approach of immune modulation and viral inhibition. AQUACULTURE, [10.1016/j.aquaculture.2024.741863] |
| 12. Deshan Yao, Liuxiang Bao, Sichuan Wang, Meng Tan, Yuanyuan Xu, Tianxu Wu, Zhengang Zhang, Kaizheng Gong. (2024) Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7A11/GPX4 axis in mice. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:38734270] [10.1016/j.freeradbiomed.2024.05.012] |
| 13. Hu Deliang, Yang Yuqing, Fang Lei, Fan Shijie, Lin Ling, Luo Puying, Xiong Yuanhuan, Su Yufang. (2024) Isoliquiritigenin induced hepatotoxicity and endoplasmic reticulum stress in zebrafish embryos. Scientific Reports, 14 (1): (1-12). [PMID:39548255] [10.1038/s41598-024-79016-8] |
| 14. Shuaishuai Chen, Weina Xue, Zhongxiu Wu, Dingyan Lu, Lin Zheng, Meng Zhou, Yongjun Li, Yonglin Wang, Ting Liu. (2025) Quercetin, a Compound of the Total Flavonoids of Periploca forrestii Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α. Journal of Inflammation Research, [PMID:40046683] [10.2147/JIR.S497166] |
| 15. Rui Yang, Kan Zhang. (2025) Synthesis of isoliquiritigenin-based bio-benzoxazine and its role of latent curing agent for achieving high-performance epoxy thermosetting systems. Materials Today Communications, [10.1016/j.mtcomm.2025.112374] |
| 16. Cang Li, Yu Huang, Yuchen Liu, Zhipeng Li, Yao Deng, Hao Ren, Donghao Zhao, Lu Han, Jian Sun. (2025) Self-assembly of Zein-based nanoparticles for oral isoliquiritigenin delivery against Salmonella infections. Innovative Food Science & Emerging Technologies, [10.1016/j.ifset.2025.104127] |
| 17. Xuewa Jiang, Shaoyan Yi, Pingping Shen, Richa Raj, Jian Zhang, Haixia Ge. (2025) Insights on the synergistic effects of glycyrrhetinic acid and isoliquiritigenin on HMGB1-induced inflammation by multi-spectroscopic and molecular docking studies. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:40714661] [10.1016/j.saa.2025.126726] |
| 18. De-Jian Chen, Cheng-Jun Liu, Zi-Hao Chen, Jin-Jin Li, Wei Shi, Qing-Min Zhang, Xia Yang, Jian-Xin Chen, Feng-Xiang Zhang. (2024) Chemical profiling of Zhi-Ke-Bao pills and its potential mechanism against cough by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry and network pharmacology. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:38815520] [10.1016/j.jpba.2024.116257] |
| 19. Jue Bai, Si-Yuan Yang, Shao-Mei Yu, Ying Cao, Chang-Han Ma, Xuan-Yi Hu, Xiong Chen, Ying-Nan Song, Hong-Jin Chen. (2025) IGFBP5 mediates the therapeutic effect of isoliquiritigenin in myocardial ischemia-reperfusion injury via AKT/GLUT4 regulated insulin resistance. Frontiers in Pharmacology, [PMID:40365313] [10.3389/fphar.2025.1544869] |
| 20. Lin Xie, Kan Zhang. (2025) Achieving very high performance polybenzoxazines from natural renewable isoliquiritigenin: design, preparation and property investigation. Polymer Chemistry, [10.1039/D5PY00311C] |
| 21. Dunsheng Liang, Xiao-Fan Shen, Ting-Ting Li, Yao Deng, Hong-Liang Xiao, Zhi-Peng Li, Shuan-Cheng Bai, Xiao-Yu Ma, Xiao-ping Liao, Dong-Hao Zhao, Hao Ren, Chaoqun Zhang, Jian Sun, Lu Han. (2025) A bionic yeast for the colon-targeted delivery of curcumin in the treatment of inflammatory bowel disease. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2025.164121] |
| 22. Li Mengyun, Zhang Xiaobing, Lu Jiafeng, Xiang Junjie, Wu Jie, Zheng Matao, Yang Siwei, He Lingyan, Shao Xian. (2025) Isoliquiritigenin ameliorates Parkinson’s disease via gut microbiota remodeling: potential mediating role of Parabacteroides distasonis. Journal of Translational Medicine, 23 (1): (1363). [PMID:41316345] [10.1186/s12967-025-07435-w] |
| 23. Shupeng Zhao, Haigang Chang, Pengju Ma, Guojun Gao, Cailing Jin, Xinli Zhao, Wenke Zhou, Baozhe Jin. (2015) Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells. International Journal of Clinical and Experimental Pathology, [PMID:26722447] [PMID:26722447] |
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