计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
提供 ≥97% 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
室温。常规运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 31 篇同行评审文献引用。
Lactobionic acid 是在里海酸奶中的一种仿生酸,化学上由与半乳糖键合的葡萄糖酸组成。Lactobionic acid 具有抗氧化剂,抗菌剂,螯合剂,稳定剂,酸化剂和保湿性能。
Lactobionic acid is an inhibitor of MMP.
An inhibitor of matrix metalloproteinases
分类树(Taxonomy Tree)
| 界(kingdom) | 有机化合物 |
|---|---|
| 超类(Superclass) | 脂质和脂质样分子 |
| 类(Class) | 脂肪酰基 |
| 亚类(Subclass) | 脂肪酰基糖苷 |
| 中间层级节点(Intermediate Tree Nodes) | 暂无 |
| 直接上位类(Direct Parent) | 单糖和双糖的脂肪酰基糖苷 |
| 其他上位类(Alternative Parents) | 双糖 O-糖基化合物 中链羟基酸及其衍生物 中链脂肪酸 β羟基酸及其衍生物 糖酸及其衍生物 杂环脂肪酸 羟基脂肪酸 α-羟基酸及其衍生物 氧烷 仲醇 一元羧酸及其衍生物 羧酸 氧环化合物 多元醇 缩醛 碳氢化合物衍生物 伯醇 有机氧化物 羰基化合物 |
| 分子骨架(Molecular Framework) | 脂肪族杂单环化合物 |
| 取代基(Substituents) | 乙醛酸 - 羟基苯甲酸酯 - 脂肪族杂单环化合物 - α-羟基酸 - β-羟基酸 - 羰基 - 羧酰胺基 - 羧酸衍生物 - 二糖 - 脂肪酸 - 单糖或双糖的脂肪酰基糖苷 - 葡萄糖酸 - 糖基化合物 - 杂环脂肪酸 - 烃衍生物 - 羟基酸 - 羟基脂肪酸 - 中链脂肪酸 - 中链羟基酸 - 单羧酸或其衍生物 - O-羧基化合物 - 有机氧化物 - 有机氧化合物 - 有机杂环化合物 - 有机氧化合物 - 氧杂环 - 氧杂环丁烷 - 多醇 - 初级醇 - 醛基 |
| 描述(Description) | 该化合物属于单糖及双糖的脂肪酰基糖苷类有机化合物。这类化合物由单糖或双糖基团与脂肪醇、磷酸化醇(磷酚醇)、羟基脂肪酸的羟基,或脂肪酸的羧基(酯键)及氨基醇相连而成。 |
| 外部描述符(External Descriptors) | disaccharide |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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| 1. Yang Fu, Chaohui Ji, Zhiheng Ma, Defeng Xu, Hang Hu. (2023) Targeted Delivery of Doxorubicin to Hepatoma Cells by Lactobionic Acid-Decorated Dual Redox-Responsive Polyethylene Glycol-Doxorubicin Nanoparticles. International Journal of Nanoscience, [10.1142/S0219581X23500199] |
| 2. Zi Chao Wu, Xin Yu Liu, Jia Yan Liu, Jing Shu Piao, Ming Guan Piao. (2022) Preparation of Betulinic Acid Galactosylated Chitosan Nanoparticles and Their Effect on Liver Fibrosis. International Journal of Nanomedicine, [PMID:36134203] [10.2147/IJN.S373430] |
| 3. Xiaohui Xiao, Yupeng Wang, Jieyao Chen, Peng Qin, Peiyao Chen, Dongfang Zhou, Yue Pan. (2022) Self-targeting platinum(IV) amphiphilic prodrug nano-assembly as radiosensitizer for synergistic and safe chemoradiotherapy of hepatocellular carcinoma. BIOMATERIALS, [PMID:36126545] [10.1016/j.biomaterials.2022.121793] |
| 4. Hang Hu, Defeng Xu. (2022) pH-Sensitive nanoparticles co-loaded with dimethylcurcumin and regorafenib for targeted combinational therapy of hepatocellular carcinoma. EUROPEAN POLYMER JOURNAL, [10.1016/j.eurpolymj.2022.111434] |
| 5. Dao-Qiang Lu, Dahai Liu, Justin Liu, Wen-Xing Li, Yilong Ai, Jun Wang, Daogang Guan. (2022) Facile synthesis of chitosan-based nanogels through photo-crosslinking for doxorubicin delivery. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:35870629] [10.1016/j.ijbiomac.2022.07.112] |
| 6. Jiahong Guo, Xiaoyu Ma, Fernando Bouffard, Sophia Yi Zhang. (2022) A Novel multi-fruit acids formula design on molecular basis for skin brightening via a system biology approach. Journal of Cosmetic Dermatology, 21 (11): (6145-6155). [PMID:35713107] [10.1111/jocd.15163] |
| 7. Yingying Zhao, Xiaoli Ji, Lili Wu, Jiaying Tian, Chaocan Zhang. (2021) Preparation of demulsifying functional membrane and its application in separation of emulsified oil. SEPARATION AND PURIFICATION TECHNOLOGY, [10.1016/j.seppur.2021.119299] |
| 8. Panxianzhi Ni, Renpeng Li, Sheng Ye, Jing Shan, Tun Yuan, Jie Liang, Yujiang Fan, Xingdong Zhang. (2021) Lactobionic acid-modified chitosan thermosensitive hydrogels that lift lesions and promote repair in endoscopic submucosal dissection. CARBOHYDRATE POLYMERS, [PMID:33858584] [10.1016/j.carbpol.2021.118001] |
| 9. Jun Wang, Zongyong Zhang, Yilong Ai, Fang Liu, Min-Min Chen, Dahai Liu. (2021) Lactobionic acid-modified thymine-chitosan nanoparticles as potential carriers for methotrexate delivery. CARBOHYDRATE RESEARCH, [PMID:33657498] [10.1016/j.carres.2021.108275] |
| 10. Hui Xu, Zijie Feng, Yingxiang Du. (2019) Synthesis, application and molecular modeling study of ionic liquid functionalized lactobionic acid, 3-methyl-1-(3-sulfopropyl)-1H-imidazol-3-ium lactobionate, as a chiral selector in capillary electrophoresis. ANALYST, 145 (3): (1025-1032). [PMID:31832629] [10.1039/C9AN02009H] |
| 11. Aiyun Liu, Huaisong Wang, Xiaoshuang Hou, Yu Ma, Gongjun Yang, Yanglong Hou, Ya Ding. (2019) Combinatory antitumor therapy by cascade targeting of a single drug. Acta Pharmaceutica Sinica B, [PMID:32322469] [10.1016/j.apsb.2019.08.011] |
| 12. Yuzhe Huang, Jian Guo, Shuangying Gui. (2018) Orally targeted galactosylated chitosan poly(lactic-co-glycolic acid) nanoparticles loaded with TNF-ɑ siRNA provide a novel strategy for the experimental treatment of ulcerative colitis. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:30315858] [10.1016/j.ejps.2018.10.009] |
| 13. Shasha He, Chan Li, Qingfei Zhang, Jianxun Ding, Xing-Jie Liang, Xuesi Chen, Haihua Xiao, Xiaoyuan Chen, Dongfang Zhou, Yubin Huang. (2018) Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine. ACS Nano, [PMID:29906087] [10.1021/acsnano.8b03476] |
| 14. Yuxia Pei, Menghuan Li, Yanhua Hou, Yan Hu, Guangyu Chu, Liangliang Dai, Ke Li, Yuxin Xing, Bailong Tao, Yonglin Yu, Chencheng Xue, Ye He, Zhong Luo, Kaiyong Cai. (2018) An autonomous tumor-targeted nanoprodrug for reactive oxygen species-activatable dual-cytochrome c/doxorubicin antitumor therapy. Nanoscale, 10 (24): (11418-11429). [PMID:29881865] [10.1039/C8NR02358A] |
| 15. Yuhua Chen, Feng Zhang, Qian Wang, Huiming Lin, Ruihan Tong, Na An, Fengyu Qu. (2018) The synthesis of LA-Fe3O4@PDA-PEG-DOX for photothermal therapy–chemotherapy. DALTON TRANSACTIONS, 47 (7): (2435-2443). [PMID:29379913] [10.1039/C7DT04080F] |
| 16. Aisha Roshan Mohamed Wali, Jie Zhou, Shengnan Ma, Yiyan He, Dong Yue, James Zhenggui Tang, Zhongwei Gu. (2017) Tailoring the supramolecular structure of amphiphilic glycopolypeptide analogue toward liver targeted drug delivery systems. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:28396247] [10.1016/j.ijpharm.2017.04.009] |
| 17. Jia Liu, Wim E. Hennink, Mies J. van Steenbergen, Renxi Zhuo, Xulin Jiang. (2016) A facile modular approach toward multifunctional supramolecular polyplexes for targeting gene delivery. Journal of Materials Chemistry B, 4 (43): (7022-7030). [PMID:32263569] [10.1039/C6TB01671E] |
| 18. Jinxia An, Xiaomei Dai, Yu Zhao, Qianqian Guo, Zhongming Wu, Xinge Zhang, Chaoxing Li. (2015) A biodegradable and fluorescent nanovehicle with enhanced selective uptake by tumor cells. Polymer Chemistry, 6 (36): (6529-6542). [10.1039/C5PY00795J] |
| 19. Meihao Liang, Xiaoliang Zheng, Linglan Tu, Zhen Ma, Zunyuan Wang, Dongmei Yan, Zhengrong Shen. (2014) The liver-targeting study of the N-galactosylated chitosan in vivo and in vitro. Artificial Cells Nanomedicine and Biotechnology, [PMID:24066968] [10.3109/21691401.2013.841173] |
| 20. Qiuxia Zheng, Jia Yao, Zongbin Sun, Rui Li, Yue Zhang, Pan Jiang, Ye Xie, Xiaojing Song, Hongfa Sun, Dan Zhu, Haixu Ni, Xun Li. (2025) Carboxymethyl chitosan/oxidized hyaluronic acid hydrogel-encapsulated hucMSC-derived exosomes for enhanced hepatic regeneration and post-hepatectomy applications. CARBOHYDRATE POLYMERS, [PMID:39914972] [10.1016/j.carbpol.2025.123248] |
| 21. Bowen Deng, Rui Huang, Rui Liang, Yang Fei, Qing Luo, Guanbin Song. (2024) Design and evaluation of collagenase-loaded nanoparticles for mechanical intervention of orthotopic hepatocellular carcinoma in rat model. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39638179] [10.1016/j.ijbiomac.2024.138311] |
| 22. Xin Yu Liu, He Ying Mao, Shuai Hong, Cheng-Hua Jin, Hu-Lin Jiang, Ming Guan Piao. (2024) Dual-targeting galactose-functionalized hyaluronic acid modified lipid nanoparticles delivering silybin for alleviating alcoholic liver injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:39241932] [10.1016/j.ijpharm.2024.124662] |
| 23. Jiahui Chen, Liping Zhang, Ting Xie, Xiao Zhang, Congcong Pan, Fangli Sun, Wenfeng Li, Zhijie Sun, Deli Dong. (2025) Nitazoxanide protects against heart failure with preserved ejection and metabolic syndrome induced by high-fat diet (HFD) plus L-NAME “two-hit” in mice. Acta Pharmaceutica Sinica B, [PMID:40370562] [10.1016/j.apsb.2024.12.040] |
| 24. Wei Tian, Hanyao Sun, Ziqing Xu, Na Li, Xi Luo, Yang Li, Jiaqi Xu, Jiajia Tang, Yafei Luo, Jie Zhang, Chen Yuan, Shangyu Lu, Haibin Shi, Shouju Wang, Sheng Liu. (2025) Gold-embedded yolk-shell mesoporous organosilica nanocomposite for microwave-enhanced targeted chemotherapy and immune modulation in hepatocellular carcinoma. BIOMATERIALS, [PMID:40644790] [10.1016/j.biomaterials.2025.123533] |
| 25. Ranran Zhao, Hongxin Liu, Zhigang Xie, Min Zheng. (2025) Targeting chiral carbon dots to enhance melanoma immunotherapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:41016112] [10.1016/j.jcis.2025.139093] |
| 26. Kun Yan, Zongrun Zhang, Xianzhu Yang, Chenguang Yang, Zhentan Lu, Dong Wang. (2025) Glycosylation-Engineered Chitosan Bioelectronic Interfaces for P. aeruginosa Gradient Analysis. ANALYTICAL CHEMISTRY, [PMID:40570237] [10.1021/acs.analchem.5c01313] |
| 27. Mengmeng Xue, Yanyan Li, Shanshan Tie, Yunling Zhang, Xue Zhang, Shichang Li, Jianrui Sun, Dongyang Zhu, Yuwan Li, Shaobin Gu. (2025) Preparation and characterization of hyaluronic acid nanoparticles for procyanidins hepatocellular and mitochondrial targeting delivery. COLLOIDS AND SURFACES B-BIOINTERFACES, [PMID:41330273] [10.1016/j.colsurfb.2025.115334] |
| 28. Ting-Ting Hu, Ying Ding, Yi-Ren Yao, Xin Zhang, Xi-Wen Zhang, Yang Gu. (2026) Erythrocyte membrane-camouflaged doxorubicin nanoparticles for enhancing therapeutic efficacy in primary liver cancer. JOURNAL OF DRUG TARGETING, [10.1080/1061186X.2026.2647068] |
| 29. Qinglin Qu, Fan Liu, Huajing Gao, Xiangrui Kong, Xue Gao, Yukun Song, Mingqian Tan, Yannan Chen, Dapeng Li, Xintong Tan. (2026) Orally engineered liver-targeted garlic exosome-like nanovesicles for astaxanthin precise delivery against alcoholic liver disease in mice. FOOD RESEARCH INTERNATIONAL, [10.1016/j.foodres.2026.119022] |
| 30. Jiahong Xie, Shiyu Liu, Yang Xu, Boyu Song, Jingli Liu, Guangyi Du, Lianghua Xie, Wei Chen. (2026) Design and fabrication of multifunctional cyanidin-3-O-glucoside-loaded nanonutriosomes with enhanced physicochemical stability and hepatic targeting for mitigating alcoholic liver injury. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2026.174791] |
| 31. Hui Zhang, Chunmei Liu, Jiahao Yang, Shanglin Li, Meng Yang, Jingbo Liu, Ting Zhang, Yajuan Li. (2026) Oral co-delivery of quercetin and anthocyanins via dual-ligand nanoparticles alleviate obesity and associated metabolic disorders. FOOD RESEARCH INTERNATIONAL, [10.1016/j.foodres.2026.119945] |