计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 4 篇同行评审文献引用。
概述
产品介绍 Lificiguat 结合到 可溶性鸟苷酸环化酶(sGC)的β亚基，在CO存在条件下，Kd 为 0.6-1.1 μM
Information
Lificiguat (YC-1) Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha) .
In vitro
YC-1 is an allosteric activator of soluble guanylyl cyclase (sGC). YC-1 increases the catalytic rate of the enzyme and sensitizes the enzyme toward its gaseous activators nitric oxide or carbon monoxide. YC-1 alone activates the enzyme only 10-fold, but it potentiates the CO- and NO-dependent activation of sGC, resulting in stimulation of the highly purified enzyme that may be several hundred- to several thousand-fold . It inhibits platelet aggregation and vascular contraction and also inhibits HIF-1 activity in vitro. YC-1 completely blocks HIF-1α expression at the post-transcriptional level and consequently inhibits the transcription factor activity of HIF-1 in hepatoma cells cultured under hypoxic conditions, suggesting that these effects of YC-1 are likely to be linked with the oxygen-sensing pathway and not with the activation of soluble guanylyl cyclase.
In vivo
The administration of YC-1 to experimental animals results in the inhibition of the platelet-rich thrombosis and a decrease of the mean arterial pressure, which correlates with increased cGMP levels . YC-1 effectively inhibits tumor growth in tumor-bearing mice. The inhibition of HIF-1 activity in tumors from YC-1-treated mice is associated with blocked angiogenesis and an inhibition of tumor growth, while the anti-platelet aggregation effect of YC-1 does not appear to affect tumor growt.
Cell Data
cell lines：A2780, Calu-3, HL-60, K562, St-4, HT-29, KB-3-1, Capan-1, 4-1St and HCT-15 cells
Concentrations：0.01-10 μM
Incubation Time：24 h
Powder Purity:≥96%
规格
别名
利菲西瓜特 (YC-1)
英文别名
2-Furanmethanol, 5-[1-(phenylmethyl)-1H-indazol-3-yl]-
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Lificiguat (YC-1)
生化机理
利匹曲阿（YC-1）是一种一氧化氮（NO）依赖型可溶性鸟苷酸环化酶（sGC）激活剂，也是缺氧诱导因子-1α（HIF-1α）的抑制剂。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激活剂
作用机制
鸟苷酸环化酶活化剂; α 1β 1; 鸟苷酸环化酶活化剂; α 2β 1
名称和识别符
技术文档
高级数据
关联靶点（人）
GUCY1A1
Tclin
鸟苷酸环化酶可溶性亚基α-1(Guanylate cyclase soluble subunit alpha-1)
(0 活性数据)
GUCY1A2
Tclin
鸟苷酸环化酶可溶性亚基α-2(Guanylate cyclase soluble subunit alpha-2)
(0 活性数据)
GUCY1B1
Tclin
鸟苷酸环化酶可溶性亚基 β-1(Guanylate cyclase soluble subunit beta-1)
(0 活性数据)
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H302: 吞食有害
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
H335: 可能引起呼吸道刺激
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 H2231003 |
分析证书 | L408938 |
技术文档和文章
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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