15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC 50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation

In Vitro

15-LOX-1 inhibitor 1 (Compound 9c) (0-5 μM; 24 hours) protects RAW 264.7 macrophages from LPS-induced cell death and shows stronger, dose-dependent effects with a 20% viability increase at 5 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: RAW 264.7 macrophages Concentration: 0, 0.2, 1, 5 μM 15-LOX-1 inhibitor 1 and lipopolysaccharides (LPS) (100 μg/mL) Incubation Time: 24 hours Result: Showed stronger, dose-dependent effects with a 20% viability increase at 5 μM.

Form:Solid

IC50& Target:15-LOX-1 0.19 μM (IC 50 )

规格

别名

15-LOX-1 抑制剂 1

规格或纯度

≥98%

英文名称

15-LOX-1 inhibitor 1

生化机理

15-LOX-1 抑制剂 1 是 15-LOX-1（15-脂氧合酶-1）的强效抑制剂，其 IC 50 值为 0.19 μM。15-LOX-1 抑制剂 1 能保护巨噬细胞免受脂多糖诱导的细胞毒性。15-LOX-1 抑制剂 1 可抑制 NO 的形成和脂质过氧化物的生成。

储存条件

-20°C储存

运输条件

超低温运输

作用类型

抑制剂

纯度

≥98%

名称和识别符

分子类型

小分子

分子量

412.87

高级数据

化学和物理性质

溶解性

DMSO : 10 mg/mL (24.22 mM; Need ultrasonic)

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

炎症与免疫反应中的脂质调控机制

目录：技术文章

探索主题:

脂质代谢胆固醇花生四烯酸炎症反应免疫调控前列腺素白三烯鞘脂脂滴炎症消退

Lipid Regulatory Mechanisms in Inflammation and Immune Responses

目录：技术文章

探索主题:

Lipid metabolism Cholesterol arachidonic acid Inflammatory Response Immune Regulation Prostaglandins Leukotrienes Sphingolipids Lipid Droplets Inflammation Resolution

溶液计算器