MICROCHIMICA ACTA
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2024
·Vol. 191
·期 6
·1-10
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IF 5.3
Zhong Yujun,Li Zhiyang,Zhang Anlin,Peng Yuqing,Zhou Hao,Wang Bin,Xie Lianwu,Guo Yaping
A novel electrochemical sensor, MIP/Cu-MOF/rGO/AuNPs/GCE, was developed by depositing gold nanoparticles, coating Cu-MOF/GO on the surface of glassy carbon electrode (GCE) before electroreducing graphene oxide (GO) to rGO and covering molecularly imprinted membrane by electropolymerization for highly sensitive detection of electroneutral organophosphorus pesticide residues in agricultural product. Cyclic voltammetry, differential pulse voltametry, scanning electron microscopy, energy-dispersive spectroscopy, and atomic force microscopy were used to characterize the imprinted sensor. Several key factors such as chitosan concentration, suspension volume, pH of polymerization solution, and polymerization scanning rate during preparation of the imprinted sensor were optimized in detail. When electroneutral phosmet was used as a template, the linear range of MIP/Cu-MOF/rGO/AuNPs/GCE for detecting phosmet was 1.00 × 10 −14 –5.00 × 10 −7 mol/L with the limit of detection of 7.20 × 10 −15 mol/L at working potentials of − 0.2 to 0.6 V. The selectivity, reproducibility, and repeatability of MIP/Cu-MOF/rGO/AuNPs/GCE were all acceptable. The recoveries of this method for determining phosmet in real samples ranged from 94.2 to 106.5%. The MIP/Cu-MOF/rGO/AuNPs/GCE sensor could be applied to detect electroneutral pesticide residues in organisms and agricultural products. Graphical Abstract
研究领域:
分析化学
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环境科学
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农业科学
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高影响因子
Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 48
·11519-11531
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IF 7
Shuhui Chen,Yu Yan,Yixuan Chen,Kaili Wang,Yawen Zhang,Xinlong Wang,Xurui Li,Jian Wen,Yue Yuan
Non-invasive cancer therapies, especially those based on reactive oxygen species, including photodynamic therapy (PDT), have gained much interest. As emerging photodynamic nanocarriers, metal–organic frameworks (MOFs) based on porphyrin can release reactive oxygen species (ROS) to destroy cancer cells. However, due to the inefficient production of ROS by photosensitizers and the over-expression of glutathione (GSH) in the tumor microenvironment (TME), their therapeutic effect is not satisfactory. Therefore, herein, we developed a multi-functional nanoparticle, HN@Cu-MOF, to enhance the efficacy of PDT. We combined chemical dynamic therapy (CDT) and nitric oxide (NO) therapy by initiating sensitization to PDT and cell apoptosis in the treatment of tumors. The Cu2+-doped MOF reacted with GSH to form Cu+, exhibiting a strong CDT ability to generate hydroxyl radicals (˙OH). The Cu-MOF was coated with HN, which is hyaluronic acid (HA) modified by a nitric oxide donor. HN can target tumor cells over-expressing the CD44 receptor and consume GSH in the cells to release NO. Both cell experiments and in vivo experiments showed an excellent tumor inhibitory effect upon the treatment. Overall, the HN@Cu-MOF nanoparticle-integrated NO gas therapy and CDT with PDT led to a significant enhancement in GSH consumption and a remarkable elevation in ROS production.
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Analytical Methods
·
2018
·Vol. 10
·期 36
·4430-4437
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IF 2.073
Yanli Zhou,Congming Li,Xiaoqiao Li,Xu Zhu,Baoxian Ye,Maotian Xu
In this study, we developed a novel and facile electrochemical aptasensor for β-amyloid (Aβ) oligomer detection based on metal–organic frameworks (MOFs) as signal probes. By using an aptamer-tethered gold nanoflower (AuNF) modified electrode for target capture and aptamer-tagged gold nanoparticles/Cu-MOF (AuNPs/Cu-MOF) conjugates for sensitive signal generation, an effective sandwich sensor was obtained for the detection of Aβ oligomers. The unique physico-chemical properties of AuNPs/Cu-MOF conjugates, such as high electrochemical activity and large surface area, endow the sensor with excellent analytical performances. The designed aptasensor exhibits a wide linear range from 1 nM to 2 μM with a linear correlation coefficient of 0.996 and a relatively low detection limit of 0.45 nM for the detection of Aβ oligomers. For the evaluation of Aβ oligomers in artificial cerebrospinal fluid, the high recoveries and accuracy indicate the feasibility, which will provide valuable information for the early diagnosis of Alzheimer's disease. Moreover, the proposed electrochemical aptasensor based on multifunctional MOFs will provide a general strategy for sensing other analytes.
研究领域:
分析化学
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生物传感器
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神经退行性疾病
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纳米技术
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MARINE POLLUTION BULLETIN
·
2023
·
IF 5.8
Liuqin Zhang,Huali Li,Xiaohu Zhang,Qiuping Li,Guangyu Zhu,Fa-Qian Liu
We developed a marine coating consisting of Cu-MOF-74, multi-walled carbon nanotube containing carboxyl groups (MWCNT-COOH) and self-healing polymers, which simultaneously possesses self-healing and anti-biofouling properties. Cu-MOF-74 can stably release Cu 2+ by virtue of the coordination dissociative mechanism. Studies have proved that MWCNT can inhibit the growth of bacteria, so adding the MWCNT can help to reduce the amount of the copper ions and ensure the antibacterial effect of the coating. In addition, the cross-linked network and abundant -COOH provided by the polymers and MWCNT-COOH further prevent the loss of copper ions. Moreover, the coating we prepared has good performance of self-healing at room temperature or slightly heated because the polymers possess abundant non-covalent hydrogen bonds . Finally, the coating not only has superior antibacterial property , but also effectively prevents the adhesion of macrofouling organism. Therefore, the coating has a longer service life and its environmental friendliness has also been improved.
研究领域:
材料科学
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海洋工程
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化学工程
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环境科学
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ANALYTICA CHIMICA ACTA
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2026
·
IF 6.1
Nanke Ma,Anqi Wei,Huiling Peng,Lixia Xie,Yuan Jin,Zhengzhi Yin,Guangli Li
Background Chirality plays a critical role in drug efficacy and environmental safety. The antibacterial activity of ofloxacin resides almost exclusively in its S-enantiomer (levofloxacin, LEV), while the R-enantiomer contributes little to therapeutic effects but may pose unnecessary risks. Rapid and reliable methods for enantioselective determination of ofloxacin enantiomers are therefore essential for pharmaceutical quality control, food safety monitoring, and environmental analysis. However, existing electrochemical sensors often suffer from limited enantioselectivity and insufficient sensitivity. To address this challenge, a novel enantioselective electrochemical platform is developed. Results A β-cyclodextrin/cerium-doped copper metal-organic framework/carboxylated multi-walled carbon nanotube composite (β-CD/Ce-doped Cu-MOF/MWCNTs-COOH) was fabricated on a glassy carbon electrode. The sensor achieves discrimination of ofloxacin enantiomers with an I L /I D ratio of 3.39. DFT calculations at pH 4.0 reveal that β-CD binds LEV with higher adsorption energy (−63.8 kJ/mol) than DEX (−58.3 kJ/mol), confirming the superior response for LEV originates from stereospecific inclusion. Quantitative analysis of LEV shows two linear ranges (0.03–1 μM and 1–10 μM) with a low detection limit of 0.01 μM. The sensor also enables accurate determination of LEV percentage in enantiomer mixtures across 0–100%. Excellent selectivity against common interferents, good reproducibility (RSD = 0.98%), repeatability (RSD = 1.26%), and long-term stability (95.2% retention after 21 days) are demonstrated. Practical applicability is validated by detecting LEV in commercial eye drops, honey, and tap water with satisfactory recoveries (96.0–108.0%). Significance and novelty This work presents the first application of Ce-doped Cu-MOF/β-CD/MWCNTs-COOH composites for the enantioselective electrochemical sensing of ofloxacin, a chiral fluoroquinolone antibiotic. The synergistic combination of high conductivity, abundant catalytic sites, and stereospecific host-guest recognition provides a generalizable strategy for high-performance enantioselective sensing, with promising applications in pharmaceutical, food, and environmental analysis.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 3
·122557
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IF 7.5
Xiaomeng Li,Yaning Ma,Ruimeng Li,Yan Ge,Jiapeng Tang
The integration of multifunctional protective materials capable of simultaneous defense against ultraviolet (UV) radiation, O 3 , and reactive oxygen species (ROS) remains a challenge in interfacial materials science, primarily due to difficulties in constructing stable and catalytically efficient interfaces on flexible substrates. Herein, we report a cellulose-guided interfacial engineering strategy for the in-situ growth of copper-based metal-organic framework (Cu-MOF) nanozymes on nylon/spandex fabric. The key to this strategy lies in the pre-coordination of Cu 2 + with the hydroxyl groups of cellulose, which molecularly guides the ordered crystallization of Cu-MOFs within a regenerated cellulose network at the fiber interface, yielding a nanosheet structure with enhanced density and accessibility of catalytic sites. The resulting cellulose-MOF hybrid is firmly anchored to the fabric through a synergistic dual mechanism: physical entrapment within the regenerated porous cellulose network provides structural integrity, while chemical coordination between Cu 2+ and cellulose hydroxyls directs oriented growth and reinforces interfacial adhesion. This precisely engineered interface enables exceptional cascade antioxidant activity (mimicking superoxide dismutase and catalase), high UV protection (UPF > 100), and rapid ozone decomposition (first-order kinetic constant k > 0.478 min −1 ). The material also demonstrates robust interfacial adhesion, ensuring mechanical durability, breathability, and wash durability (>30 cycles). Biocompatibility was confirmed by skin irritation tests. This work highlights the critical role of biomass-templated interfacial microstructure in regulating catalytic performance and provides a green, scalable paradigm for designing advanced functional interfaces for environmental and biomedical protection.
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TALANTA
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2026
·
IF 6.1
Kaiqiang Yang,Junlei Liu,Yiming Yang,Wenying Li
Natural products and their synthetic analogs have historically been fundamental to drug discovery, making their identification crucial for pharmaceutical research. This work presents a nanozyme-based sensor array for precise discrimination and quantitative determination of seven phenolic acids in plant-derived natural products. By modulating ligand hydrophobicity, we engineered three POD-mimicking Cu-MOF nanozymes (Cu-MI, Cu-EI, and Cu-PI), with their catalytic activity exhibiting increased catalytic activity proportional to the ligand alkyl chain length. Based on this, a four-channel sensor array was constructed using the distinct activities of Cu-MI and Cu-PI. In this array, the target phenolic acids selectively inhibit the nanozyme-catalyzed oxidation of 3,3',5,5'-tetramethylbenzidine (TMB), generating unique fingerprint-like responses for each analyte. The array achieved 100% accurate classification of all seven phenolic acids using linear discriminant analysis (LDA) and hierarchical cluster analysis (HCA). Furthermore, the array allowed for the sensitive quantification of phenolic acids, offering a wide linear range (5–50 μM, R 2 > 0.99) and low detection limits (0.56–4.1 μM). The practical utility was rigorously validated through interference tests and the analysis of Lonicera japonica extracts. The assay accurately identified chlorogenic acid as the predominant phenolic acid in Lonicera japonica , determined its content, and demonstrated excellent accuracy with spike recoveries of 94.5–103.2%. This study establishes a robust and reliable strategy for the quality assessment of natural products.
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CHEMOSPHERE
·
2023
·
IF 8.8
Ge Zhang,Weihong Wu,Meng Yao,Yumeng Cui,Yunhong Jiao,Hongqiang Qu,Jianzhong Xu
The traditional method of preparing graphene will cause serious environmental pollution, and the combustion of polymer materials will seriously harm people's health. In this paper, a Cu-MOF-coated graphene composite flame retardant (G@Cu-MOF) rich in flame retardant elements such as B and N was synthesized through green mechanical ball milling method. Flame retardants reduce the threat to the environment and people's lives and property. After adding 6 wt% G@Cu-MOF, the peak heat release rate, total heat release rate, CO production and CO 2 production of epoxy resin (EP) composite samples decreased by 55, 14, 59, and 55%, respectively. This type of Cu-MOF releases incombustible gases such as boron trifluoride (BF 3 ) and ammonia (NH 3 ) during combustion, diluting the concentration of combustible gases and producing copper borate in the condensed phase. Cu 2+ is reduced to Cu, and boron compounds are converted into boron oxides. The thermal conductivity of graphene can reduce the temperature of the matrix, and has good flame retardancy. It synergistically acts with Cu-MOF to promote the formation of high-quality residual char, and can significantly inhibit the heat and smoke release of EP. It plays a role in flame retardancy and protecting the substrate from fire. This study provides a new approach for preparing graphene hybrid flame retardants through mechanical ball milling, in order to improve the flame retardancy of EP and suppress the release of smoke and toxic gases.
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Chemosensors
·
2023
·Vol. 11
·期 8
·431
·
IF 4.2
Yushuang Guo,Mingli Chen,Ting Yang,Jianhua Wang
As the most abundant catecholamine neurotransmitter in the brain, dopamine plays an important role in the normal physiological process, and its level in urine also changes during human pathological processes. In clinic, the detection of dopamine in urine is a potential marker for the diagnosis and the treatment of endocrine-related diseases. In this work, a copper metal organic framework with catecholase-like activity was prepared via the precipitation of Cu2+and imidazole, simulating the N-Cu coordination environment in the active site of catecholase. Cu-MOF (the copper–metal organic framework) can catalyze the oxidation of DA (dopamine) to dopaquinone using O2in the air. The oxidation product can further react with 1,3-dihydroxynaphthalene to produce a fluorophore product. Based on the above reaction, a multimodal sensing platform with three signal outputs, including ratio-metric fluorescence, absorbance and digital information extracted from smartphone images for simple and sensitive determination of DA, was proposed, with detection limits of 0.0679, 0.3206, and 0.3718 μM, respectively. This multimodal sensing platform was able to detect DA in body fluid in a self-correcting way, as demonstrated by the successful determination of DA in normal human urine samples, and samples with a high level of interference.
研究领域:
生物化学
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医学诊断
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材料科学
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Surfaces and Interfaces
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2026
·
IF 6
Wanru Suo,Run Huang,Tao Yang,Hao Yu,Liu Yang,Peixuan Zou,Yusong Pan,Rui Yue,Lei Huang
Metal-organic frameworks (MOFs), such as Cu-MOF, have emerged as highly efficient tumor drug carriers due to their tunable particle size, adequate adsorption property, and good biocompatibility. In this work, Cu-MOFs with different sizes were synthesized by employing a micelle-confined strategy via controlling the concentration of the polyvinylpyrrolidone (PVP) template. At a PVP concentration of 400 mM, the X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) results jointly confirmed that Cu-MOF nanoparticles (named as Cu-MOF- 400 ) with an average grain size of 167 nm were successfully synthesized. The Cu-MOF -400 exhibited a good crystal structure with the regular octahedral morphology, and possessed a pore diameter of about 1.83 nm with the elements (Cu, C, and O) distributed evenly on the surfaces. In vitro co-culturing experiments revealed that the Cu-MOF -400 exhibited low cytotoxicity to 293T cells, while achieving antibacterial inhibition rates of 58.3% and 69.1% against Gram-negative bacteria ( Escherichia coli ) and Gram-positive bacteria ( Staphylococcus aureus ), respectively. With the aid of the pore structure, Cu-MOF- 400 had a drug loading efficiency (DLE) of 78.3% for doxorubicin (DOX) within 24 h, and the DOX-loaded system (named as Cu-MOF -400 @DOX) demonstrated significant pH-responsive drug release properties in the tumor microenvironment (pH 5.2), with a cumulative release rate of 54.75% over 72 h, which is 6.3 times higher compared to that under the physiological conditions (pH 7.4), fitting well to the Korsmeyer-Peppas model. In addition, Cu-MOF -400 @DOX inhibited the survival of HeLa tumor cells to 42.2% (a killing rate of 57.8%) at a concentration of 9 μg·mL -1 , which might be due to the good cellular-uptake effect of the drug-loaded system; as the Cu-MOF -400 @DOX achieved complete intracellular localization within 6 h, which significantly facilitated the acid-triggered DOX release. With good cytocompatibility and bactericidal effect, and after DOX loading, the nanosystem displays excellent pH-responsive drug release to efficiently suppress tumor-cell growth in vitro, offering a new strategy for the development of new-type drugs in clinic for tumor treatment and bacterial resistance prevention.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 42
·32799-32819
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IF 4.4
Yang Lutao,Zhou Chuanchen,Zhang Fang,Yang Jie,He Lei,Zhang Jun
Given the ongoing global demand for oil, polymer–surfactant binary flooding technology plays a key role in enhancing oil recovery. However, in high-temperature, high-salinity, and high-calcium/magnesium reservoirs, traditional binary flooding systems face limitations due to thermal degradation, salt sensitivity, and formation adsorption, significantly reducing their effectiveness. In this study, a novel magnetic nanocomposite, BS@Fe 3 O 4 /MOF, was synthesized using Cu-based metal–organic framework (Cu-MOF)-doped Fe 3 O 4 magnetic nanoparticles and functionalized with dodecyldimethyl betaine (BS-12). The nanocomposite effectively removed Ca 2+ and Mg 2+ ions. Emulsification tests optimized the binary surfactant/polymer (SP) flooding system with octylphenol ethoxylate (OP-10) and xanthan gum (XG) and verified the feasibility of constructing the SP-BS@Fe 3 O 4 /MOF system. The system showed strong tolerance to high temperatures, salinity, and varied pH environments, with a substantial increase in viscosity and ultra-low interfacial tension in crude oil. Adsorption loss was 14%, with separation rates of 8.28% for the nanocomposite and 17.86% for XG. Oil recovery tests showed an 8.22% improvement, and magnetic recovery added another 3.75%. Overall, BS@Fe 3 O 4 /MOF enhances binary flooding, providing a strategic solution for field application challenges.
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高影响因子
SOLID STATE SCIENCES
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2026
·
IF 3.6
Haixia Wang,Chuang Liu,Yilei Sun,Zeda Meng,Won-Chun Oh
Successful synthesis of copper-metal organic framework (Cu-MOF) and carbon nanotube (CNT)-doped CNT/Cu-MOF composites • Stability and CO 2 reduction activity of the as-prepared materials with electrochemical performance • Catalytic properties of the highest double-layer capacitance (3.25 mF cm -2 ) with a maximum current density reaching -18 mA cm -2 • Total Faradaic efficiency for CH 4 and CO reached 21% In this study, Cu-MOF and CNT/Cu-MOF composite materials (CNT/Cu-MOF-0.3, CNT/Cu-MOF-0.5, CNT/Cu-MOF-1) modified by doping with different proportions of CNT were successfully synthesized via the solvothermal method. Through analyzing the linear sweep voltammetry curve, electrochemical activity, electrochemical impedance spectroscopy, and electrocatalytic selectivity bar graph, we found that the catalyst with a CNT doping ratio of 0.5 exhibited the lowest overpotential, its maximum current density reaches -18 mA·cm -2 , and demonstrating the best catalytic performance among the four materials. Its double-layer capacitance was the highest, reaching 3.25 mF·cm -2 with a combined Faradaic efficiency of 21% for CH 4 and CO at -1.6V (vs. RHE). Download: Download high-res image (202KB) Download: Download full-size image
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