ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2018
·Vol. 25
·期 31
·31705-31717
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IF 2.8
Zheng Xiang,Wang Jinlin,Xue Xiaolong,Liu Wanxia,Kong Yadong,Cheng Rong,Yuan Donghai
In this research, the adsorptive removal of diclofenac sodium, one of the representative pharmaceuticals and personal care products, from aqueous solution using Fe 3 O 4 @MOF-100(Fe) magnetic microspheres was studied for the first time. The Fe 3 O 4 @MOF-100(Fe) microspheres exhibit strong magnetism and stability, which were observed as a core-shell structure. The maximum adsorption capacity of Fe 3 O 4 @MOF-100(Fe) for diclofenac sodium can reach 377.36 mg L −1 , which was higher than most of the adsorbents reported. The adsorption kinetics follows the pseudo-second-order kinetic equation. And the adsorption equilibrium of DCF can be described with Langmuir isotherm. In the cycle experiment, Fe 3 O 4 @MOF-100(Fe) material performed high adsorption efficiency for low-concentration diclofenac sodium solution, and the removal rate can still reach 80% after 5 cycles of adsorption without desorption. The mechanisms including electrostatic interaction, H-bond interaction, and π-π interaction that coexisted in the adsorption processes would be of benefit to enhance the adsorption capacity. The Fe 3 O 4 @MOF-100(Fe) magnetic microspheres offer exciting opportunities for further application.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Zi-Yu Li,Jia-Hui Zhu,Sheng-Nan Lv,Jie Zhao,Xiao-Shuai Yang,Yu-Shen Liu,Zhen-Hua Hu,Ting Cheng,Yan-Xin Chen,Lu-Liang Wang
Diclofenac (DCF), as fifth veterinary drugs, is a popular non-steroidal anti-inflammatory drug, widely applied in pain relief and anti-inflammatory of humans and animals, and endanger human health and food safety. Developing the effective technology for the removal or trace detection of DCF is urgent. Therefore, rational design and preparing advanced and selective adsorbent is extremely significant. Herein, a novel sulfonic acid (Sa) functionalized covalent organic frameworks (Fe 3 O 4 @TpbDva-Sa) were designed and prepared to enrich and determine trace DCF in milks with the aid of high performance liquid chromatography (HPLC). Fe 3 O 4 @TpbDva-Sa adsorbent was well characterized. The parameters of magnetic solid phase extraction (MSPE), adsorption kinetic and isotherm were evaluated in detail. Furthermore, adsorption mechanism of Fe 3 O 4 @TpbDva-Sa for DCF was investigated. The developed Fe 3 O 4 @TpbDva-Sa-MSPE-HPLC method was validated and employed to detect trace DCF in food samples. The established method displayed low dosage (2 mg), good linearity (8 × 10 -4 -10 μg mL −1 ), low limit of detection (2.4 × 10 -4 μg L -1 ), large adsorption capacity (98.03 mg g −1 ), good reusability and satisfactory recoveries (87–98 %). This work reported the novel magnetci sulfonic acid-based covalent organic frameworks for MSPE of DCF. The results revealed the great potency of Fe 3 O 4 @TpbDva-Sa for enriching the residues of veterinary drug in complex matrix and uncovered the prospects of functional covalent organic frameworks in sample pretreatment.
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SOLID STATE SCIENCES
·
2024
·
IF 3.4
Nan Li,Mianmian Wu,Zhimin Guo,Qingfei Li,Guifang Sun,Wenjing Shen,Minghao Shi,Jiangquan Ma
Piezoelectric materials can harvest mechanical energy and convert it into electrical energy, which have lately become highly effective catalysts to sustainable eliminate pollutants. Here, by adding different surfactants to metal-organic framework adenine-UiO-66 (AD-U) materials, the metal-organic framework adenine-UiO-66 (AD-U-S) modified by sodium dodecyl benzene sulfonate (SDBS) and the metal-organic framework adenine-UiO-66 (AD-U-C) modified by cetyltrimethylammonium bromide (CTAB) were prepared for the first time. With the antibiotic diclofenac sodium (DCF) as the target pollutant, the degradation efficiencies of AD-U-S (0.30) and AD-U-C (0.30) were 98 % and 78 % in 30 min, respectively. Specially, the reaction rate constant of AD-U-S (0.30) is 3.5 times that of AD-U-C (0.30). The performance improvement is due to the larger specific surface area, stronger ferroelectric properties , enhanced oxidation capability and higher charge transfer efficiency of AD-U-S (0.30) than that of AD-U-C (0.30). The capture experiments showed that ‧OH and h + were the main active species on AD-U-S (0.30) and AD-U-C (0.30) during the removal of DCF. In addition, possible pathways for DCF piezodegradation were obtained by liquid-phase mass spectrometry and DFT calculations. This study is benefit to promote the development of piezocatalytic technology for wastewater treatment.
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JOURNAL OF ELECTRONIC MATERIALS
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2025
·
IF 2.5
Tang Linghui,Huang Yufeng,Wang Yue,Zhao Hongbin
The development of a selective, sensitive, and effective electrochemical sensor for the simultaneous analysis of multiple drugs presents a significant and urgent challenge. In this work, an electrochemical sensor capable of separating and detecting paracetamol (PAR) and diclofenac sodium hydrochloride (DIC) was constructed through the synthesis of a carbon nanotube (CNT)-doped hydrogel. Because of the hydrophilic functional groups on CNTs, they can be uniformly dispersed in organic precursor solution to form a homogeneous conductive hydrogel. The structure and morphology of the CNT-doped hydrogel was studied by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The operating conditions of the sensor were optimized, including the hydrogel volume, electrolyte pH, electrochemical deposition potential, and deposition time. Under optimal working conditions, the linear ranges for PAR and DIC detection were 10–80 μM and 10–80 μM, with detection limits of 3.5 and 3.6 μM, respectively. In addition, the hydrogel sensor demonstrated good reproducibility, long-term stability, excellent flexibility in bending and twisting, and favorable mechanical properties, with a maximum strain rate of 478% and tensile strength of 0.102 MPa. This research provides a new flexible material for drug separation sensors, and opens up a new research platform for hydrogels.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2025
·
IF 8
Chuan Liang,Yang Chen,Yunzhe Ling,Peirun Li,Jiahao Liu,Xuantian Li,Yanhua Xu,Zhiying Liu
Non-steroidal anti-inflammatory drugs (NSAIDs), though designed to target specific molecular pathways, pose significant environmental risks to non-target organisms, particularly marine fish. This study investigated the toxicity mechanisms and adaptive responses to diclofenac (DCF) and meloxicam (MEX) during the early life stages (ELS) of Oryzias melastigma at environmentally relevant concentrations over a 31-day period. Mechanistic investigations of sub-lethal effects were conducted using Enzyme-Linked Immunosorbent Assay (ELISA), RNA sequencing (RNA-Seq) and quantitative PCR (qPCR). The results revealed that cyclooxygenase (COX) inhibition disrupted the renin-angiotensin system, leading to an accumulation of angiotensin II and cardiovascular developmental defects. Additionally, downregulation of the pla2 gene reduced substrates essential for COX enzyme activity, exacerbating the effects. Although NSAIDs are known to affect the digestive system, no significant effects on developmental factors were observed. RNA-Seq and qPCR analyses revealed an adaptive upregulation of key genes, including ace2 and cyp7a1 , involved in cardiovascular and metabolic regulation. Furthermore, 16S rRNA sequencing identified shifts in the microbial community, particularly in g_Rubritalea and g_Sphingomonas genera. Both the upregulated genes and the altered microbial taxa likely played a role in mitigating toxic effects and promoting homeostasis. Moreover, molecular docking suggested that MEX exhibited stronger sub-lethal effects than DCF, likely due to its higher binding affinity to COX. These findings provide valuable insights into NSAID toxicity mechanisms in marine fish, highlighting the importance of adaptive responses in countering environmental stress and underscoring the long-term ecological risks of chronic NSAID exposure.
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Environmental Science-Nano
·
2025
·
IF 5.1
Lingrong Chen,Yishun Wang,Fengyuan Zhang,Yanfang Wang,Yunshuang He,Hongda Zhan,Xiaoyu Zhang,Ping Chen,Zili Lin,Wenying Lv,Guoguang Liu
Photocatalytic technology is a promising solution for effectively removing diclofenac (DCF) from wastewater. Herein, we report the theoretical design and solvothermal synthesis of a cyano-modified copper phenylacetylide (PhC2Cu) photocatalyst (Cy-PhC2Cu), addressing the bottleneck of rapid charge carrier recombination in pristine PhC2Cu. The strong electron-withdrawing nature of cyano (-CN) not only facilitates photogenerated electron transfer on copper(I) sites and induces oxygen activation but also lowers the valence band (VB) energy level, thereby promoting the generation of highly oxidizing holes (h⁺) to enhance the production of 1O2 . Characterizations confirm that doping of -CN exhibits a broadened light absorption range and superior photocatalytic activity toward DCF degradation under visible light. Specifically, Cy-PhC2Cu achieved a 97.0% DCF degradation rate within 100 min, which is 5.99 times higher in kinetics than pure PhC2Cu. In the photocatalytic process, electrons are excited by copper(I) and enter the benzene ring ligand through alkynyl groups. The presence of electron-deficient -CN can further capture these electrons, avoiding their rapid return to copper under strong coulomb forces within the molecule, resulting in effective exciton separation, which was confirmed by the combined results of photoluminescence (PL) spectra and density functional theory (DFT) calculations. This work demonstrates that rational functional group engineering paves the way for designing advanced photocatalysts with optimized optoelectronic transport for water treatment applications.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Chenghong Qiang,Nan Li,Shixiang Zuo,Zhimin Guo,Wei Zhan,Zhengping Li,Jiangquan Ma
Seeking active and low-cost cocatalysts is a vital task for solving the sluggish kinetics of photocatalysis process in environmental management. Herein, we report a novel and high-efficiency crystallized RuTe 2 cocatalyst, and loaded it onto black TiO 2 to form photocatalytic heterostructure (denoted as RuTe 2 /B-TiO 2 ) for diclofenac (DCF) degradation. To the best of our knowledge, the RuTe 2 as a cocatalyst for photocatalysis based on swift electron capture has not been documented yet. The degradation efficiency of DCF over 0.5% RuTe 2 /B-TiO 2 reached 95.2% for 120 min, which is 1.2 times higher than that of pure B-TiO 2 . In addition, the effects of different calcination temperatures, catalyst amounts, DCF concentrations and solution pH of the as-prepared catalysts were also investigated in depth. Spectroscopy/electrochemistry showed that 0.5% RuTe 2 /B-TiO 2 exhibited a narrower band gap, more active sites and better electrical conductivity than pure B-TiO 2 . Experiments with trapping agents have shown that O 2 – was the main active substance under irradiation. Furthermore, intermediates for the photodegradation of DCF were detected by liquid chromatography mass system (LC-MS) and density functional theory (DFT) calculations. Finally, the degradation pathway was rationalized and a possible photocatalytic mechanism for 0.5% RuTe 2 /B-TiO 2 was proposed.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Zemin Li,Shuyan Xiang,Yin Pan,Li Fu
In this work, gold nanoparticles were prepared by reduction using Ginkgo biloba extract and modified with a glassy carbon electrode to investigate the electrochemical behavior of diclofenac. The effect of temperature on the synthesis of gold nanoparticles was investigated. The results showed that the best gold nanoparticles were synthesized at 180 °C. SEM characterized the prepared gold nanoparticles, and the size distribution was about 50~100 nm. During the electrochemical detection of diclofenac, two experimental parameters, the modification amount and the sweep rate were optimized, and a modification amount of 5 μL and a sweep rate of 100 mV/s were determined. The performance of the green synthesized gold nanoparticle modified electrode for the electrochemical detection of diclofenac was investigated using cyclic voltammetry with linear detection limits ranging from 5 to 600 μM and the lowest detection limit of 0.524 μM. In addition, the effect of impurity ions (molecules) on the electrochemical detection of diclofenac at gold nanoparticle-modified electrodes was investigated, and the results showed that none of the impurities measured affected the qualitative detection of diclofenac.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2018
·
IF 3.927
Ruonan Guo,Xinhui Xia,Xinyi Zhang,Bo Li,Huixuan Zhang,Xiuwen Cheng,Mingzheng Xie,Qingfeng Cheng
This work shows results of our investigation on Ag 3 PO 4 /TiO 2 NTAs photoelectrode photodegradation properties to diclofenac with visible light illumination. The composite photoelectrode has been synthesized by ultrasound-precipitation strategy and characterized through scanning electrons microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). In addition, photoelectrochemical and visible photocatalytic activity properties of as-prepared samples were investigated to prove the fact. Compared with pure TiO 2 NTAs, Ag 3 PO 4 /TiO 2 NTAs photoelectrode possesses the enhancement of light absorbance in the visible region and a lower recombination rate of photogenerated electron–hole pairs, so that it performed a better visible light photocatalytic property. Additionally, prepared Ag 3 PO 4 /TiO 2 NTAs photoelectrode has well recyclability. On the basis of electrochemical, fluorescence spectra and photoluminescence, the photocatalytic performance enhancement mechanism for Ag 3 PO 4 /TiO 2 NTAs was put forward.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ming Wang,Jianlin Li,Wenjie Pan,Jiaqi Li,Wu Xu,Zhenshan Ding,Qingsong Yu,Zhihua Gan,Zhibo Li,Ni Jiang
The use of physical barriers is an effective strategy for preventing postoperative adhesion, a prevalent complication in clinical abdominal surgeries. However, the current anti-adhesion barriers face limitations in precisely regulating key cellular responses during tissue repair. In this study, a multi-modal synergistic degradable anti-adhesion membrane was developed via coaxial electrospinning of poly(4-hydroxybutyrate) (P4HB), polyglycolic acid (PGA), and diclofenac sodium (DS). The designed membrane features a densely packed fibrous architecture, exhibiting over 97 % inhibition efficiency against fibroblasts interlayer penetration in vitro. The rapid initial release of DS synergizes with PGA-mediated biological functions to suppress fibroblast-to-myofibroblast differentiation, and to significantly mitigate early-stage pathological changes. This cascade effect ultimately leads to reduced collagen deposition and significantly diminished adhesion formation, as demonstrated in a mouse cecal and peritoneal abrasion model. Furthermore, the membrane demonstrates exceptional flexibility and enhanced hydrophilicity, ensuring conformal coverage of complex three-dimensional wounds. The integration of structural design, controlled drug release, and dynamic biological modulation renders this multifunctional barrier as a promising candidate for next-generation clinical anti-adhesion applications.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6
Zhiran Ju,Junde Xu,Keshuang Tang,Fener Chen
COX-2/NLPR3-targeted therapy might be beneficial for the inflammation diseases. To discover novel anti-inflammatory compounds with favorable safety profiles, three new series of non-carboxylic diclofenac analogues bearing various ring systems, such as oxadiazoles 4a - 4w , triazoles 6a - 6m , and cyclic imides 7a and 7b , were synthesized. The synthesized analogues were evaluated for their inhibitory activity against COX-2 enzyme. Among them, compound 6k exhibited potent selective COX-2 inhibition (IC 50 = 1.53 μM; selectivity ((IC 50 (COX-1)/IC 50 (COX-2) = 17.19). Treatment with compound 6k effectively suppressed the NF-κB/NLRP3 signaling pathway, resulting in reduced expression of pro-inflammatory factors. The in vivo ulcerative colitis assay demonstrated that compound 6k significantly ameliorated histological damages and showed strong protection against DSS-induced acute colitis. The collected results indicated that compound 6k displays anti-inflammatory activity through COX-2/NLRP3 inhibition. Therefore, compound 6k represents a promising candidate for further development as a new lead compound with reduced colitis side effects.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2024
·
IF 10.8
Yang Zhou,Zhu Zeng,Junhao Fu,Yuan Gao,Jinxing Ma,Zhong Zhang,Daoyuan Zu,Bin Han,Xixin Lu,Jun Ma,Jin Jiang
Humic acid (HA) ubiquitously existing in aquatic environments has been reported to significantly impact permanganate (KMnO4) decontamination processes. However, the underlying mechanism of the KMnO4/HA system remained elusive. In this study, an enhancing effect of HA on the KMnO4 oxidation of diclofenac (DCF) was observed over a wide solution pH range of 5–9. Surprisingly, the mechanism of HA-induced enhancement varied with solution pH. Quenching and chemical probing experiments revealed that manganese intermediates (Mn(III)-HA and MnO2) were responsible for the enhancement under acidic conditions but not under neutral and alkaline conditions. By combining KMnO4 decomposition, galvanic oxidation process experiments, electrochemical tests, and FTIR and XPS analysis, it was interestingly found that HA could effectively mediate the electron transfer from DCF to KMnO4 in neutral and alkaline solutions, which was reported for the first time. The formation of an organic–catalyst complex (i.e., HA-DCF) with lower reduction potential than the parent DCF was proposed to be responsible for the accelerated electron transfer from DCF to KMnO4. This electron transfer likely occurred within the complex molecule formed through the interaction between HA-DCF and KMnO4 (i.e., HA-DCF-KMnO4). These results will help us gain a more comprehensive understanding of the role of HA in the KMnO4 oxidation processes.
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