Molecular Catalysis
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2025
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IF 4.9
Jinghui Lyu,Tao Liu,Shihao Wang,Jun Wei,Jinke Yao,Yiyong Zhao,Han Wu,Xianghao Zhang,Peikun Li,Zhizheng Wang,Qunfeng Zhang,Dahao Jiang,Qingtao Wang,Guofu Zhang,Chengrong Ding,Xiaonian Li
TS-1 zeolite is a catalyst known for its high selective oxidation performance and broad industrial applications. The titanium atom in the TS-1 often acts as the active center in catalytic reactions, especially in oxidation reactions, so increasing the titanium content in TS-1 is of great significance in chemical reactions and catalytic applications. This paper explores a Novel Boron Extraction and Titanium Incorporation Strategy to enhance the titanium content within the TS-1 framework. During the dry gel preparation process, boron species were introduced in situ into the framework of the TS-1 to form a framework boron-titanium-silicon TS-1-B with tetra-coordinated or tri-coordinated positions. TS-1-B is then treated with acid to remove the framework boron, while an appropriate amount of titanium precursor is introduced to fill the vacancy left by the removal of the framework boron. The results of XRD, FT-IR, UV–Vis, BET, NH 3 -TPD, XRF, and XPS showed that the titanium content of the tetracoordinate framework in the TS-1 was improved. The catalytic performances of TS-1-B, TS-1-BS, and TS-1-BST were comparatively evaluated through two representative reactions: propylene epoxidation and the direct synthesis of hydrogen peroxide from H₂ and O₂.
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Biomaterials Advances
·
2025
·
IF 6
Yi Zhu,Yiting Lou,Mengyuan Zhang,Jiafei Sun,Boxin Zhang,Yuting Ye,Zhewei Li,Junqing Lu,Ben Wan,Gang Wu,Qianhui Li,Ping Sun
The regeneration of critical-sized bone defects is severely hampered by a dual challenge: insufficient vascularization and limited osteogenic activity at the injury site. Histatin-1 (Hst1), a salivary peptide with known pro-angiogenic and regenerative activities, is a hopeful candidate for bone regeneration, yet its dual function in osteogenesis and angiogenesis remains underexplored. Here, we systematically elucidated this dual function. In vitro , Hst1 was demonstrated to stimulate the osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs) through the activation of the Wnt/β-catenin signaling pathway. Concurrently, Hst1 promoted tube formation through paracrine signaling. In vivo , the hydrogel formulated from oxidized sodium alginate (OSA), gelatin (GE), and adipic acid dihydrazide (ADH) was employed to ensure the sustained delivery of Hst1. This Hst1-loaded hydrogel was applied to a 5-mm critical-sized cranial defect in rats. Compared to the Control group, Hst1-loaded hydrogel significantly enhanced bone regeneration, with the bone volume fraction (BV/TV) increasing to 20.0 % ( vs. 8.2 % for Control). This was accompanied by a marked increase in vascularization, as evidenced by a 3.0-fold rise in vessel density. In conclusion, this study reveals the dual pro-regenerative function of Hst1 in simultaneously promoting osteogenesis and angiogenesis, demonstrating that harnessing Hst1 within a sustained-release hydrogel is a powerful therapeutic strategy for achieving vascularized bone regeneration.
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MICROVASCULAR RESEARCH
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2025
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IF 2.7
Xiao Xu,Xiaohu Ge,Hongbo Ci,Maitiseyiti Abulaihaiti,JianPing Yang,YangYang Li,Feng Zhu
Background Thromboangiitis obliterans (TAO, Buerger's disease) is a chronic inflammatory disorder that affects small and medium-sized vessels in the limbs. Although the pathogenesis of TAO remains incompletely understood, elevated levels of plasminogen activator inhibitor-1 (PAI-1) have been associated with cardiovascular diseases. This study investigates the mechanism by which PAI-1 activates the NF-κB/NLRP3 inflammatory pathway in vascular endothelial cells through hypoxia-inducible factor-1α (HIF-1α), contributing to the progression of TAO. Methods Proteomic analysis was performed on plasma samples from 5 TAO patients and 5 healthy controls to identify differentially expressed proteins (DEPs). In vitro, human umbilical vein endothelial cells (HUVECs) were subjected to 1 % hypoxia to mimic TAO conditions. Interventions included PAI-1 knockdown using lentiviral vectors and treatment with the HIF-1α agonist dimethyloxalylglycine (DMOG). Cell viability was assessed using the CCK-8 assay, apoptosis was measured by flow cytometry, and inflammatory factor levels were detected by enzyme-linked immunosorbent assay (ELISA). Protein expression was analyzed by Western blotting. In vivo, a TAO rat model was established by sodium laurate injection. The severity of limb ischemia was evaluated using gross lesion grading and infrared thermography, while pathological changes were assessed by hematoxylin and eosin (H&E) staining and Masson's trichrome staining. Results Elevated levels of PAI-1, HIF-1α, and key molecules in the NLRP3/NF-κB pathway were observed in both TAO rats and hypoxic HUVECs. PAI-1 knockdown significantly improved limb ischemia and suppressed the NLRP3/NF-κB pathway in TAO rats. Compared with the DMOG intervention group, combined treatment with PAI-1 knockdown and DMOG effectively alleviated ischemic symptoms, increased body weight, and reduced the expression of HIF-1α and inflammatory pathway molecules in TAO rats. Conclusion PAI-1 promotes the progression of TAO by activating the NF-κB pathway via HIF-1α. Targeted inhibition of PAI-1 represents a potential therapeutic strategy for TAO.
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MATERIALS & DESIGN
·
2025
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IF 7.9
Jingxia Chen,Jing Xu,Huixin Lv,Jiaxin Luo,Zhen Ci,Yangfan Pei,Yihan Wang,Xiuyu Liu,Sicong Ren,Sheng Chen,Siyu Chen,Ting Zhu,Jingjie Zhai,Yanmin Zhou
Jawbone defects pose significant challenges for oral implantation and restoration. Guided bone regeneration is the most common strategy for bone augmentation. However, inadequate efficiency of osteogenesis remains a persistent issue. Periosteum serves as a potential source of osteogenesis, but insufficient mesenchymal stem cells (MSCs) in periosteum often exist due to the lack of initial bone support. Inadequate blood supply near the submembranous osteogenic region also impedes the osteogenesis process. This paper proposes a dual cross-linked natural protein-derived hydrogel, GelMA-fibrinogen/NELL-1(GFN), which optimizes both physical and biological factors to stabilize the elevated maxillary sinus membrane (MSM) (an anatomical structure involved in osteogenesis in maxillary posterior dental region, resembling periosteum) and support the osteogenic space. The results showed stem cells derived from the membrane could migrate to GFN and exhibit robust proliferation capability. Under osteogenic induction, the adequately expanded MSM-derived MSCs enhanced osteogenic differentiation under the synergetic guidance of fibrinogen and Nell-1 through TGF-β/HIF-1α/β-catenin signaling pathway. In vivo experiments showed that GFN could promote bone formation with double-layered cortical bone structures in maxillary sinus region, which provides a new direction for construction of bone grafting materials.
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DESALINATION
·
2025
·
IF 9.8
J.Y. Chen,X.N. Ren,X.W. Gao,Z.X. Yang,G.G. Cheng,X.H. Hu,D.T. Bui
The development of next-generation desiccant materials is essential for achieving energy-efficient atmospheric water harvesting and air dehumidification under hot and humid conditions. Conventional desiccants such as silica gel and zeolites are limited by high regeneration temperatures, low water uptake, or poor hydrothermal stability, while salt-based sorbents suffer from deliquescence and leakage. To address these challenges, this study presents a LiCl@TpPa-1 covalent organic framework (COF) composite that integrates the structural robustness of TpPa-1 with the hygroscopic functionality of lithium chloride. Structural and thermodynamic analyses confirmed that LiCl incorporation enhances water affinity without compromising crystallinity or stability, enabling low-temperature regeneration below 70 °C. The composite was successfully coated onto aluminum heat exchanger fins using an optimized polymeric binder, yielding a uniform, durable sorption layer. System-level testing demonstrated a more than threefold improvement in moisture removal and a 2.5-fold increase in thermal coefficient of performance (COP) compared to silica gel under tropical conditions. This study goes beyond material-level characterization by bridging the gap between laboratory synthesis and practical application. The composite was successfully coated onto aluminum heat exchanger fins using an optimized polymeric binder, forming a uniform and durable sorption layer. System-level testing under realistic operating conditions demonstrated more than a threefold enhancement in moisture removal and a 2.5-fold increase in the thermal COP compared to silica gel under tropical climates. The material also exhibited excellent cyclic stability with negligible capacity loss after repeated dehumidification–regeneration cycles. These results highlight LiCl@TpPa-1 as a promising desiccant for sustainable, low-grade heat-driven dehumidification and water-harvesting technologies.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2025
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IF 8.4
Jiantao Zhu,He Wen,Xiaofei Liu,Shuai Zhang,Jinkun Wang,Chunbo He,Wei Han,Yinghong Han,Dongying Yang,Na Song
Global climate change has been a serious issue, and the innovation of CO 2 reduction technologies has become a universal consensus and trend. The preparation of hierarchical porous metal-organic frameworks (MOFs) is an effective approach to improve CO 2 adsorption performance due to the accelerating the diffusion of gas flow and exposing more adsorptive pore surface. In this study, an innovative synthesis method that enlarges the pore size of HKUST-1 through utilizing nitrogen doped graphene quantum dots (NGQDs) was developed to induce defect formation during its self-assembly process. The mesoporous and total pore volume of HKUST-1@NGQDs-3 was 0.27 and 0.48 cm 3 /g, respectively, which was 58.8 % and 23.1 % higher than those of pure HKUST-1. The HKUST-1@NGQDs-3 exhibited high CO 2 adsorption capacity of 4.03 mmol/g at 1 bar, elevated up to 53.8 % compared to pristine HKUST-1 owing to its mesoporous structure. Importantly, the CO 2 /N 2 selectivity was significantly improved up to 31.7 % at 1 bar compared to HKUST-1. Additionally, the isosteric heat of adsorption for HKUST-1@NGQDs was lower than that of pure HKUST-1, facilitating the regeneration of adsorbent. This work presents a simple and efficient strategy for the developing MOFs-based composites for enhanced CO 2 capture.
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Experimental and Therapeutic Medicine
·
2025
·Vol. 31
·期 1
·1-8
·
IF 2.3
Jeng-Yuan Yao,De-Tian-Yu Tzeng,Cai-Hong Feng,Gong-Man Xiao,Tian-Ni You,Ru-Yu Zheng
Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.
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Advanced Science
·
2025
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IF 14.1
Huimin Yuan,Senlin Li,Shuai Liu,Hong Zhou,Yue Xu,Wenhui Li,Mengxuan Wang,Mengheng Wang,Mengzhu Zheng,Wenxi Shi,Xin Li,Yiting Feng,Ming Xiang
Type 1 diabetes (T1D) is an autoimmune disorder marked by the injury of pancreatic β cells, during which sympathetic neurons in the endocrine region of pancreas are lost, whereas those in the exocrine regions surrounding islets remain intact. This abnormal sympathetic nervous signaling may disrupt the balance of the neuroendocrine-immune network and contribute to the development of T1D, although its underlying molecular mechanisms are still elusive. Here, single-cell omics and whole-tissue immunostaining reveal a decrease in pancreatic sympathetic nerve density in T1D patients and T1D mouse models. Surgical and chemical desensitization of the sympathetic nervous system exacerbates T1D, while macrophage depletion mitigates this effect. Mechanistically, diminished norepinephrine (NE) release impairs β2-adrenergic receptor (β2-AR)-PKA-CREB1 signaling in islet macrophages, leading to downregulation of the adaptor caspase recruitment domain family member 9 (CARD9). Loss of CARD9 decreases SLC6A8-mediated creatine uptake, shifts macrophages toward a pro-inflammatory phenotype, and promotes sympathetic axon ferroptosis driven by decreased neurotrophic factor and anti-inflammatory factor release. Conversely, β2-AR agonist formoterol restores PKA-CREB1-CARD9 activation, preserves creatine metabolism, and maintains anti-inflammatory macrophage polarization. These findings define a novel sympathetic-macrophage-creatine metabolic axis governed by CARD9 that links neural signals to immune and metabolic regulation in T1D, highlighting neuroimmune interactions as targets for therapies.
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Foods
·
2025
·Vol. 14
·期 21
·3787
·
IF 5.1
Jinlong Luo,Siyu Liao,Fengjiao Ding,Yuqiao Dai,Zhongying Liu,Ting Yang,Tuo Zhang,Shimao Fang,Yan Li,Lulu Pu,Ke Pan,Wanping Fang,Qiang Shen
‘Qiancha 1’ is an excellent raw material for manufacturing white tea. The effects of different drying parameters on the quality performance of ‘Qiancha 1’ white tea remain poorly understood, which restricts the precise regulation of the quality of ‘Qiancha 1’ white tea. In this research, we systematically investigated the influence of drying temperature (65 °C, 75 °C, and 90 °C) and drying duration (1 h, 2 h, and 3 h) on its non-volatile and volatile compositions, using sensory evaluation, E-tongue, and non-volatilomic and volatilomic analyses. The results showed that the tea sample dried at 65 °C for 3 h had a sweet, mellow, and fresh flavor and scored 95 points, but high-temperature drying (90 °C) could promote increased bitterness and decreased sweetness. High-temperature drying was closely related to a caramel-like and milk-like flavor, which promoted an increase in the content of terpenoids, heterocycle compounds, and esters. During drying, the flavonoid and phenolic acid content increased markedly, contributing to bitterness and astringency, while nucleotides, amino acids, and their derivatives decreased, leading to a reduced umami intensity. A total of 37 key taste-active metabolites were identified, including bitter compounds (e.g., alkaloids), sweet compounds (e.g., phenolic acids), and umami compounds (e.g., nucleotides), whose dynamic changes directly influenced the taste profile of white tea. High-temperature drying promoted an increase in the content of volatile metabolites, such as terpenoids, heterocyclics, and esters, while low-temperature and long-duration drying was beneficial for preserving volatile metabolites like heptanal. 2-Methoxy-3-(1-methylethyl)-pyrazine was determined as the volatile compound with the highest rOAV, providing a sweetness and caramel-like flavor. Overall, the metabolomic analysis revealed that the content of flavonoids and phenolic acids increased after the drying process, which was related to the bitter and astringent taste of the tea liquor. The content of nucleotides, amino acids, and their derivatives decreased after drying, which caused the umami of the tea liquor to weaken. This study provides a theoretical basis for the optimization of the ‘Qiancha 1’ white tea drying process.
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PROCEEDINGS OF THE COMBUSTION INSTITUTE
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2025
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IF 5.2
Meng Yang,Chang Liu,Chenglong Tang,Zuohua Huang
Hypergolic ionic liquids have wide range of potential applications in the propulsion field due to their low toxicity, high thermal stability, and safe handling; however, their high costs and unclear hypergolic ignition mechanisms have limited their development to date. In this work, nitromethane (NM), as an additive, was blended with 1-ethyl-3-methylimidazolium dicyanamide ([EMIm][DCA]) to obtain a new fuel with low viscosity and cost. The hypergolic ignition behaviors of [EMIm][DCA]/NM blends reacting with white fuming nitric acid (WFNA) were then investigated through drop tests. Two high speed cameras and a time-resolved infrared camera were used to record the macro and micro hypergolic ignition processes and the reaction region’s temperature evolution. The effects of the Weber number and NM blend ratio ( α ) on the hypergolic probability and ignition delay time (IDT) of the [EMIm][DCA]/NM blends were investigated. The results show that with increasing impact velocity, more smoke-like vapor and tiny droplets were formed, which promotes the hypergolic ignition probability and decreases the IDT. As increasing NM blend ratios, the hypergolic ignition performance is initially similar to pure [EMIm][DCA] ( α ≤ 30 %) and then decreases rapidly ( α > 30 %). This indicates that when α ≤ 30 %, fuels with excellent hypergolic ignition characteristics can be obtained, whose raw materials costs may be up to ∼25 % lower than pure [EMIm][DCA]. Finally, a hypothesized pre-ignition pathway of [EMIm][DCA]/NM was proposed based on the experimental data and physical characteristics of the system.
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CELL PROLIFERATION
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2025
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IF 5.6
Changsen Bai,Jialei Hua,Donghua Meng,Yue Xu,Benfu Zhong,Miao Liu,Zhaosong Wang,Wei Zhou,Liming Liu,Hailong Wang,Yang Liu,Lifang Li,Xiuju Chen,Yueguo Li
Glutaminase-1 (GLS1) has garnered considerable interest as a metabolic target in cancer due to its heightened involvement and activity. However, the precise fate of glutaminolysis catalysed by GLS1 in cancer cells remains elusive. We found that GLS1 knockout led to significant suppression of cancer cell proliferation, which can be reversed or partially restored by supplementation of glutamate or non-essential amino acids that can be converted into glutamate. The addition of spliceosomal KGA or GAC ameliorates cancer cell growth in vitro and in vivo, providing both simultaneously completely reverse the effect. The primary metabolic fate of glutamate produced through glutaminolysis in cancer cells is mainly used to produce glutathione (GSH) for redox homeostasis, not entering the tricarboxylic acid cycle or synthesising nucleotides. GSH monoethyl ester (GSH-MEE) effectively rescues the inhibition of cancer cell proliferation caused by GLS1 knockout. Deletion of GLS1 results in an elevation of reactive oxygen species (ROS) and malondialdehyde (MDA), a reduction of NADPH/NADP + ratio, and an augmented susceptibility of cells to ferroptosis. Glutathione Peroxidase 4 (GPX4) and GPX1 exhibit complementary roles in redox regulation, with GLS1 knockout promoting GPX4 degradation. Pharmacological inhibition of GLS1 synergises with GPX4 inhibitor to suppress tumour growth. Dual targeting of GPX4 and GPX1 presents a potent anti-cancer strategy. This metabolic mechanism facilitates a deeper comprehension of the abnormal glutamine metabolism in cancer cells, establishing a theoretical basis for the potential clinical utilisation of GLS1 inhibitors and presenting novel perspectives for advancing combinatorial therapeutic approaches.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
Qianwen Cao,Luyao Liu,Xiaoge Ma,Chaomin Zhong,Mengqi Tang,Mengge Liu,Ling-Bo Qu,Bo Wei,Xia Xu
1, 8-Cineole (Cin), a cyclic monoterpenoid derived from tea trees and eucalyptus species, exhibits diverse pharmacological properties. Yet, its therapeutic impact and underlying mechanism against Staphylococcus aureus (S. aureus) pneumonia remain to be elucidated. In this study, metabolomics based on UPLC-MS/MS was integrated with network pharmacology, molecular biology, and molecular docking to investigate the effects of Cin. The findings demonstrated that Cin markedly reduced mortality and lung bacterial load, lessened pulmonary damage while suppressing the levels of proinflammatory factors, including tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in the bronchoalveolar lavage fluid (BALF) of infected mice. Additionally, 19 metabolites, primarily involved in tryptophan metabolism and arginine biosynthesis, were notably modified by Cin via suppressing the enzymatic activity of indoleamine 2, 3-dioxygenase 1 (IDO1) and inducible nitric oxide synthase (iNOS), thereby attenuating the inflammatory response. Notably, knockdown of IDO1 or iNOS significantly diminished the anti-inflammation effect of Cin. In conclusion, our study validates the therapeutic potential of Cin against S. aureus pneumonia via anti-inflammation by downregulating IDO1 and iNOS. Our results provide a theoretical basis of natural substances applied in bacterial pneumonia treatment.
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