Biomaterials Science
·
2021
·Vol. 9
·期 20
·6830-6841
·
IF 6.843
Liming Ruan,Gao Song,Xueya Zhang,Tianqi Liu,Yanfang Sun,Junlan Zhu,Zhiyong Zeng,Guohua Jiang
The development of multifunctional nanoformulations (NFs) include several features in a single nanosystem for these devices to overcome the disadvantages of inefficiency and undesirable toxicity of traditional therapies and provide new opportunities in the management of tumors. Herein, multifunctional CaO2@Mn-PDA NFs with a core–shell structure, integrating the photothermal conversion properties of Mn-PDA, the chemodynamic properties of doped Mn ions, and relieving hypoxia in the tumor microenvironment (TME) were developed. The as-fabricated CaO2@Mn-PDA NFs were embedded in microneedles (MNs) for transdermal delivery into tumor sites, leading to the generation of a new minimally invasive and synergistic therapeutic strategy against skin melanoma. Under near-infrared (NIR) light irradiation, the CaO2@Mn-PDA NFs exhibited a synergistic therapeutic effect, including photothermal therapy (PTT), chemodynamic therapy (CDT), and modulating hypoxia due to their high photothermal conversion efficiency, boosted intracellular production of reactive oxygen species, excellent chemodynamic reactions, etc. Therefore, the developed MN platform, which can build implanted multifunctional characteristics for on-demand NIR-induced synergistic therapy, have a bright future in tumor suppression.
研究领域:
生物医学工程
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纳米技术
·
癌症治疗
·
药学
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 45
·21759-21766
·
IF 6.97
Tao Zhang,Zhenqi Jiang,Ting Xve,Shan Sun,Juan Li,Wenzhi Ren,Aiguo Wu,Pintong Huang
Constructing nanocarriers with high drug loading capacity is a challenge, which limits the effective delivery of drugs to solid tumors. Here, we reported a one-pot synthesis of hollow nanoparticles (NPs) encapsulated by doxorubicin (DOX) and modified with polydopamine (PDA) to form PDA@DOX NPs for breast cancer treatment. PDA@DOX NPs demonstrated exceptionally high capacity (53.16%) for loading DOX. In addition, when PDA@DOX NPs were administered systemically, they exhibited responsive aggregation in the tumor sites and demonstrated a good controlled release effect for DOX due to the weak acidic environment of the tumor sites and targeting near-infrared (NIR) light irradiation. The PDA outer layer absorbed the near-infrared (NIR) light and facilitated simultaneous generation of heat energy for destroying the tumor cells to release the drug upon NIR irradiation. Moreover, this NIR-activated combined/synergistic therapy exhibited remarkably complete tumor growth suppression in a breast cancer mouse model. Importantly, NPs exhibited a good ultrasound performance both in vitro and in vivo, which could monitor the treatment process. In conclusion, this NIR-activated PDA@DOX NP system is demonstrated as a good US-guided combination (chemotherapy + PTT) therapy platform with high loading capacity and controlled drug release characteristics, which is promising for the treatment of breast cancer.
研究领域:
癌症治疗
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纳米医学
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生物医学工程
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药学科学
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医学影像
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jinhong Cai,Shuhan Liu,Qiuling Zhong,Yifeng Shang,Zhengrong Chen,Yi Yao,Bo Zhou,Feiying Yin,Jinmin Zhao,Li Zheng
An ideal wound dressing has both efficient antimicrobial and anti-inflammatory properties, as well as the potential to regulate the immune microenvironment for the treatment of chronically infected wounds. Herein, a novel multifunctional hydrogel wound dressing (HPZ8) was developed for wound healing by incorporating polydopamine Zeolite Imidazole Framework 8 (PDA-ZIF8) nanoparticles into a dynamic cross-linked network consisting of hydrazide-modified hyaluronic acid (HA-CDH) and oxidized hyaluronic acid (HA-CHO). The results suggested that the HPZ8 hydrogel could be injected into the wound to form a barrier, facilitating tissue adhesion and rapid hemostasis. After loaded with PDA-ZIF8 nanoparticles, the hydrogel exhibited excellent antioxidant and photothermal antimicrobial properties, which could effectively scavenge ROS, reduce oxidative stress and eliminate bacterial infections. Especially, near-infrared (NIR) irradiation strengthened the photothermal therapy (PTT). Besides, HPZ8 hydrogel could release zinc ions to promote cell migration, angiogenesis and M2 polarization of macrophages, accelerating macrophage transition from inflammation to proliferation stages, thus promoting infected wound healing. Therefore, the HPZ8 multifunctional hydrogel dressing has application prospects for the therapy of chronic infected wounds.
研究领域:
生物材料
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伤口愈合
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纳米技术
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生物医学工程
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免疫学
✓ 已验证
产品关联
DOI
高影响因子
Bio-Design and Manufacturing
·
2022
·Vol. 5
·期 2
·233-248
·
IF 5.887
Su Tingshu,Zheng Ao,Cao Lingyan,Peng Lingjie,Wang Xiao,Wang Jie,Xin Xianzhen,Jiang Xinquan
Following dental implantation, the characteristic bacterial milieu of the oral cavity may lead to peri-implant inflammation, which can negatively impact osseointegration and cause implant failure. To improve soft tissue sealing around the implant, enhance osseointegration, and improve implant success rates, this paper proposes a composite multifunctional coating (PHG) prepared using gelatin and polydopamine/hydroxyapatite nanoparticles, investigates the effects of this novel coating on cell adhesion, proliferation, antibacterial activity, osteogenic differentiation, and evaluates its immune-related properties. The PHG coating was proved to have satisfactory hydrophilicity and wettability for cell attachment. Furthermore, it improved the expression of adhesion-related genes and proteins in human gingival fibroblasts, indicating its adhesion-promoting effect. Additionally, bone marrow mesenchymal stem cells exhibited strong osteogenic differentiation potential and mineralization on PHG-coated surfaces. Notably, the PHG coating exhibited antibacterial activity against Streptococcus mutans , as well as anti-inflammatory effects, potentially via the regulation of macrophages. Therefore, the proposed PHG coating may promote soft tissue sealing and bone bonding, providing a potential strategy for the surface modification of dental implants.
研究领域:
牙科学
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生物材料
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组织工程
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免疫学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Tao Dong,Guangze Sun,Wanjian Liu,Yunze Long,Aihua Liu
Acute respiratory infections (ARIs) are among the leading causes of morbidity and mortality worldwide, with Mycoplasma pneumoniae (M. pneumoniae) and Chlamydia pneumoniae (C. pneumoniae) being major pathogens responsible for community-acquired respiratory infections. Rapid and accurate diagnosis is critical for improving patient outcomes and effectively controlling disease transmission. Herein, we report a novel dual-channel lateral flow immunoassay (DC-LFIA) platform based on the Co3O4@polydopamine (PDA) nanocomposite with outstanding extinction coefficient, oxidase-like activity, and magnetic properties for the simultaneous detection of specific IgM antibodies (Ab) against these two pathogens in human serum. The magnetic properties of the Co3O4@PDA nanocomposite enable rapid enrichment of trace target Abs from large-volume serum samples, with a high extinction coefficient for direct colorimetric visualization and an excellent oxidase-like catalytic activity for signal enhancement. On the basis of the multifunctional Co3O4@PDA nanocomposite, rapid dual-mode detection of serum Abs was achieved within 12 min. By the direct colorimetric mode, the visual limit of detection (vLOD) for M. pneumoniae Ab and C. pneumoniae Ab reached 2 and 1 ng/mL, respectively, while the oxidase-like catalyzing signal amplification mode further lowered the vLODs to 0.2 and 0.1 ng/mL, accordingly. Additionally, the signal normalization using a 3D-printed device significantly enhanced assay accuracy and reproducibility. When applied to 96 clinical serum samples, compared to commercial kits, this multifunctional Co3O4@PDA-based DC-LFIA demonstrated superior performance, providing a reliable approach for simultaneous antibody detection in respiratory infection diagnosis. Overall, this work contributes a valuable diagnostic tool to the field of rapid detection of ARIs.
研究领域:
免疫学
·
临床检验医学
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纳米生物技术
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传染病学
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诊断学
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转化医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2018
·
IF 0
Yang Zhang,Guohua Jiang,Wenjie Hong,Mengyue Gao,Bin Xu,Jiangying Zhu,Gao Song,Tianqi Liu
Herein, an NIR-responsive polymeric microneedle (MN) system incorporated with metformin-loaded and polydopamine/lauric-acid-coated (PDA/LA-coated) hollow mesoporous SiO2 has been developed for transdermal delivery of antidiabetic drug (metformin). First, an antidiabetic drug was loaded within hollow mesoporous SiO2 nanoparticles (HMSNs) by a diffusion method. Then, PDA as photothermal conversion agent and lauric acid (LA) as phase change material (PCM) were coated onto the HMSN to form NIR-responsive drug nanocarriers. Finally, these metformin-loaded and PDA/LA-coated HMSNs were encapsulated into poly(vinylpyrrolidone) (PVP) MNs. After insertion into skin tissue, LA could melt with the photothermal conversion of PDA under NIR light, thus enabling release of encapsulated metformin from MNs. The in vivo release behavior of metformin from MNs into skin was further studied to investigate its hypoglycemic effect on diabetic rats. Compared with the subcutaneous injection of metformin, the bioavailability of MN–NIR groups was 95.8 ± 2.7%. The antidiabetic drug can be precisely released by adjustment of exposure time and power densities of NIR light.
研究领域:
药学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Shuangqin Tian,Xin Shi,Shujie Wang,Yi He,Bifang Zheng,Xianhong Deng,Ziqin Zhou,Wenbin Wu,Kai Xin,Lihong Tang
With the ever-increasing challenge of heavy metal pollution, the imperative for developing highly efficient adsorbents has become apparent to remove metal ions from wastewater completely. In this study, we introduce a novel magnetic core–shell adsorbent, Fe 3 O 4 @UiO-66-PDA. It features a polydopamine (PDA) modified zirconium-based metal–organic framework (UiO-66) synthesized through a simple solvothermal method. The adsorbent boasts a unique core–shell architecture with a high specific surface area, abundant micropores, and remarkable thermal stability. The adsorption capabilities of six metal ions (Fe 3+ , Mn 2+ , Pb 2+ , Cu 2+ , Hg 2+ , and Cd 2+ ) were systematically investigated, guided by the theory of hard and soft acids and bases. Among these, three representative metal ions (Fe 3+ , Pb 2+ , and Hg 2+ ) were scrutinized in detail. The activated Fe 3 O 4 @UiO-66-PDA exhibited exceptional adsorption capacities for these metal ions, achieving impressive values of 97.99 mg/g, 121.42 mg/g, and 130.72 mg/g, respectively, at pH 5.0. Moreover, the adsorbent demonstrated efficient recovery from aqueous solution using an external magnet, maintaining robust adsorption efficiency (>80%) and stability even after six cycles. To delve deeper into the optimized adsorption of Hg 2+ , density functional theory (DFT) analysis was employed, revealing an adsorption energy of -2.61 eV for Hg 2+ . This notable adsorption capacity was primarily attributed to electron interactions and coordination effects. This study offers valuable insights into metal ion adsorption facilitated, by magnetic metal–organic framework (MOF) materials.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2017
·
IF 4.162
Shuo Li,Qiong Wu,Pinyi Ma,Yue Zhang,Daqian Song,Xinghua Wang,Ying Sun
A novel surface plasmon resonance (SPR) biosensor based on hollow gold nanospheres (HGNPs) and an improved sandwich assay was developed to detect rabbit IgG. The electromagnetic coupling between the HGNPs and Au film, and the notable plasmonic fields spread over the inner and outer surfaces of HGNPs, led to the considerable amplification of the SPR signal. [email protected] 3 O 4 /reduced graphene oxide ( [email protected] 3 O 4 /rGO) was introduced to bind detection antibody (Ab 2 ) to form the improved sandwich structure. Ag nanoparticles were excited to produce SPR and their hot electrons were doped on graphene thin films, which amplified the response of biomolecules. Magnetic nanoparticles (Fe 3 O 4 ) simplified the collection of Ab 2 [email protected] 3 O 4 /rGO. An external layer of polydopamine (PDA) permitted the efficient immobilization of Ab 2 without activation via abundant functional groups and protected the nanoparticles from etching or agglomeration. In addition, because of its large mass, Ab 2 [email protected] 3 O 4 /rGO also played a key role in the further amplification of the SPR response signals. This novel SPR biosensor exhibited an effective response to the rabbit IgG at the different concentrations ranging from 0.019 to 40.00 μg mL −1 . This value is 132 times lower than that observed for a traditional SPR biosensor based on Au-3-mercaptopropionic acid and 8 times lower than that obtained from an Ab 2 sandwich assay, which indicates that the SPR sensor has high sensitivity. In addition, the designed biosensor showed satisfactory recoveries to detect the rabbit IgG spiked in serum samples. Therefore, the novel SPR biosensor with high sensitivity and acceptable recovery has potential for practical applications.
研究领域:
纳米技术
·
生物传感器
·
分析化学
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Jingguang Wang,Yutao Lin,Tao Wang,Zhenze Xie,Wenxin Guo,Chang Du
Cancer treatment techniques often struggle to simultaneously address the issues of significant impact from cancer heterogeneity, poor resistance to drugs, and non-selective drug toxicity. Therefore, cancer treatment strategies based on nanoplatforms with multiple responsive properties have attracted wide attention due to their broad applicability and minimal side effects on normal cells. Herein, we constructed a nano iron-based metal–organic framework loading Pt and coated with polydopamine (Fe-MOF-NH 2 @Pt@PDA) using the solvothermal method for multimodal cancer therapy. The Pt and Fe could leverage the unique weak acidity and overexpression of hydrogen peroxide in the tumor cell to generate reactive oxygen species (ROS) for chemodynamic therapy (CDT). Additionally, Pt and Fe gave its peroxidase-like activity to produce oxygen, improving the hypoxic environment in the tumor microenvironment. Due to Pt, Fe-MOF-NH 2 @Pt@PDA achieved excellent sonodynamic therapy (SDT) under ultrasound (US) stimulation. Under US, more ROS were generated, enhancing the anticancer effect of CDT. Moreover, Fe-MOF-NH 2 @Pt@PDA produced an excellent photothermal effect under 808 nm near-infrared (NIR) irradiation for photothermal therapy (PTT). Furthermore, Fe-MOF-NH 2 @Pt@PDA exhibited good biocompatibility. Taken together, the nano Fe-MOF-NH 2 @Pt@PDA with synergistic CDT, SDT, and PTT combined treatment was a promising biomaterial for non-invasive clinical cancer therapy.
研究领域:
纳米医学
·
肿瘤学
·
材料科学
·
生物医学工程
·
诊疗学
·
生物化学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Penghui Wang,Jiongming You,Guang Liu,Qiming Wang,Linjie Zhang,Xinwu Lu,Jinbao Qin,Zhihui Dong,Bingcheng Yi,Qun Huang
Biomaterial-assisted therapeutic strategies enable precise modulation to direct endogenous cellular responses and harness regenerative capabilities for nerve repair. However, achieving effective cellular engagement during nerve remodeling remains challenging. Herein, a novel composite nerve guidance conduit (NGC), the GelMA/PLys@PDA-Fe@PLCL conduit is developed by combining aligned poly( l -lactide-co-caprolactone) (PLCL) nanofibers modified with polydopamine (PDA), ferrous iron (Fe 3 ⁺), and polylysine (PLys) with aligned methacrylate-anhydride gelatin (GelMA) hydrogel nanofibers. PDA films exhibit strong adhesion and metal coordination properties, allowing Fe 3 ⁺ irons to chelate with phenolic hydroxyl groups of dopamine derivatives, forming a metal-phenolic network on PLCL. PLys molecules are then grafted onto PDA-Fe 3 ⁺ coating via Schiff base and Michael addition reactions. This multifunctional coating enhances surface roughness and zeta potential of PLCL nanofibers, imparts superhydrophilicity with anisotropic wetting behavior, and maintains wet tensile properties of substrates. In vitro studies show that the PLys@PDA-Fe coating significantly promotes aligned distribution of Schwann cells, improves cell adhesion and differentiation, and demonstrates notable antioxidant and anti-inflammatory properties. When implanted into nerve defects in rats, the multifunctional coating conduit combined with aligned GelMA hydrogel effectively accelerates axonal regeneration, remyelination, and angiogenesis, leading to enhanced motor function recovery. Overall, the GelMA/PLys@PDA-Fe@PLCL conduit presents a promising strategy for advancing peripheral nerve repair.
研究领域:
生物材料
·
组织工程
·
神经科学
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Xiaoyi Li,Xueshan Zhao,Ruiqi Liu,Hui Wang,Shuang Wang,Bing Fan,Chenggong Hu,Haibo Wang
Conductive hydrogel sensors have attracted attention for use in human motion monitoring detection, but integrating excellent biocompatibility, mechanical, self-adhesive, and self-healing properties, and high sensitivity into a hydrogel remains a challenge. In this work, a novel multifunctional conductive particle was designed and added to a polyacrylamide (PAM) matrix to prepare the hydrogel. It is worth noting that with the addition of polydopamine@poly(3,4-ethylenedioxythiophene) (PDA@PEDOT), the PAM/PDA@PEDOT hydrogel (PAPP hydrogel) showed excellent mechanical properties and high adhesion strength on different substrate surfaces. Meanwhile, the PAPP hydrogel shows outstanding self-healing properties, the mechanical properties of PAPP hydrogel broken from the middle recovered 92% tensile strength and 95% elongation at break after 12 h, respectively. Furthermore, assembled as strain wireless sensors, the PAPP sensor displays high sensitivity, where the gauge factor (GF) is 2.82, which can be used to accurately detect human facial micro-expressions and movements. Overall, the PAPP hydrogel with excellent mechanical, self-adhesive, and self-healing properties, and high sensitivity, demonstrated promise for use in wearable devices and bionic skins.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
可穿戴设备
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2025
·
IF 4.5
Fan Zhang,Yi-liang Zou,Rui Lou,Jing-hui Yang,De-xiang Sun,Nan Zhang,Yong Wang
Environment-friendly dielectric materials with high energy density and charge–discharge efficiency are urgently required in dielectric capacitors. Here, we prepared the cellulose acetate (CA)-based sandwich-structured composite films by solution casting technique. To reduce the conductivity of MXene and upgrade the compatibility between filler and matrix, MXene was modified by polydopamine (PDA) to obtain MXene@PDA (M@P) hybrid filler, and then it was added into CA matrix to manufacture CA/M@P as the middle layer to significantly improve dielectric constant, while poly(vinylidene fluoride) (PVDF) with excellent insulation property was designed as the outer layers. The results indicate that the strong hydrogen bonding interaction between layers is conducive to the dense internal structure of the composite films, and a prominently strengthened discharged energy density (12.53 J/cm 3 ) and efficiency (72.12%) at 625 MV/m are reached in composite film containing 1 wt% M@P, with ultrahigh stability during the 10 6 consecutive charge-discharge measurements. Furthermore, the composite films also exhibit good mechanical properties. This work suggests the practicability of CA in substituting petroleum-based polymers in the dielectric capacitors.
研究领域:
材料科学
·
高分子科学
·
电气工程
·
纳米技术
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）