MOLECULAR PHARMACEUTICS
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2023
·
IF 4.9
Rui Chang,Rongrong Fu,Yujiao Huang,Jibing Zhang,Changshun Feng,Rui Wang,Hui Yan,Guangyong Li,Xiaohong Chu,Fengjiao Yuan,Dianlong Jia,Jun Li
Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) constitutes a promising antitumor drug, tumor resistance to TRAIL has become a major obstacle in its clinical application. Mitomycin C (MMC) is an effective TRAIL-resistant tumor sensitizer, which indicates a potential utility of combination therapy. However, the efficacy of this combination therapy is limited owing to its short half-life and the cumulative toxicity of MMC. To address these issues, we successfully developed a multifunctional liposome (MTLPs) with human TRAIL protein on the surface and MMC encapsulated in the internal aqueous phase to codeliver TRAIL and MMC. MTLPs are uniform spherical particles that exhibit efficient cellular uptake by HT-29 TRAIL-resistant tumor cells, thereby inducing a stronger killing effect compared with control groups. In vivo assays revealed that MTLPs efficiently accumulated in tumors and safely achieved 97.8% tumor suppression via the synergistic effect of TRAIL and MMC in an HT-29 tumor xenograft model while ensuring biosafety. These results suggest that the liposomal codelivery of TRAIL and MMC provides a novel approach to overcome TRAIL-resistant tumors.
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高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Baoyang Lu,Yao Lu,Yangping Wen,Xuemin Duan,Jingkun Xu,Shuai Chen,Long Zhang
A novel chiral L-alanine-modified 3,4-ethylenedioxythiophene (EDOT) precursor, (2S)-(2,3-dihydrothieno[3,4- b ][1,4]dioxin-2-yl)methyl 2-( tert -butoxy carbonylamino)propanoate (EDOT-Boc-Ala), was synthesized and electropolymerized in CH 2 Cl 2 –Bu 4 NBF. The corresponding polymer, poly((2S)-(2,3-dihydrothieno[3,4- b ][1,4]dioxin-2-yl)methyl 2-( tert -butoxy carbonylamino)propanoate) (PEDOT-Boc-Ala) film showed good redox activity and stability. The electrochemical behavior, structural characterization, chirality, solubility, spectroscopic properties, thermal stability, and morphology of PEDOT-Boc-Ala film were investigated. Both doped and dedoped PEDOT-Boc-Ala film could well dissolve in strong polar solvents such as dimethyl sulfoxide, tetrahydrofuran, and acetone, etc. The determination of specific rotation showed that the electropolymerization of EDOT-Boc-Ala did not influence its conformation and the polymer exhibited an enhanced specific rotation ([α] 20.0 = -191.08°) in comparison with that of the monomer ([α] 20.0 = -30.77°). Moreover, the amperometric biosensor based on PEDOT-Boc-Ala film (as immobilization matrix of biologically-active species) was successfully fabricated and employed to determine the concentration of vitamin C.
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CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Dongdong Yang,Shun Dong,Jianqiang Xin,Chen Liu,Peitao Hu,Liansen Xia,Changqing Hong,Xinghong Zhang
Carbon aerogel (CA) has been generally regarded as a potential electromagnetic wave (EMW) absorber, but unsatisfactory microwave absorption, mechanical and anti-oxidation properties are still the primary challenges for its application. Herein, a novel C/SiOC composite aerogel (CSA) was successfully synthesized by a simple copolymerization of dual sols, ambient pressure drying and thermal treatment process for the first time. The morphology and performance of the as-prepared CSA could be tailored just by controlling the initial ratio of silane and phenolic resin (PR) to adjust the content of SiOC in CSA, whose density was in the range of 0.252 to 0.294 g·cm −3 with a low thermal conductivity from 0.061 to 0.067 W·m −1 ·K −1 . Notably, the EMW absorption capacity of CSA was greatly enhanced with the increase of SiOC content, with the optimal reflection loss (RL ) value of −67.85 dB and effective absorption bandwidth (EAB) of 6.88 GHz, which was dramatically improved than CA (–22.89 dB, 5.34 GHz) and mainly ascribed to the optimized impedance matching characteristics and strong attenuation capacity. Meanwhile, compared with CA (2.63 MPa) with a density of 0.248 g·cm −3 , the mechanical properties of CSA (3.30–5.12 MPa) were also remarkably improved, and the maximum compression strength was nearly doubled. Furthermore, CSA obtained superior oxidation resistance than CA and exhibited excellent flame-retardant properties. All the results indicated that CSA could be considered as a highly promising candidate for applications in extreme environments due to its lightweight, high strength and outstanding microwave absorption capacity along with good oxidation resistance, superior thermal insulation performance and high flame retardancy.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2023
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IF 3.8
Fuping Tian,Xinchi Zhang,Yingying Sheng,Xiao Chen,Xiang Wang,Changhai Liang
The liquid phase selective hydrogenation of cinnamaldehyde has been investigated over the catalysts Co-C- T ( T = 400–700 °C), which were derived from the carbonization of the MOF precursor Co-BTC at different temperatures in inert atmosphere. Co-C-500 exhibited a higher conversion (85.3%) than those carbonized at other temperatures, with 51.5% selectivity to cinnamyl alcohol, under a mild condition (90 °C, 4 h, 2 MPa H 2 , solvent: 9 ml ethanol and 1 ml water). The high catalytic activity of Co-C-500 can be ascribed to the large specific surface area of the catalyst, the uniformly dispersed metallic cobalt nanoparticles , and the more defect sites on the carbon support. Moreover, Co-C-500 showed excellent reusability in 5 successive cycles, mainly related to the uniformly dispersed cobalt nanoparticles embedded in carbon support.
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JOURNAL OF ELECTRONIC MATERIALS
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2023
·Vol. 52
·期 7
·4484-4494
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IF 2.1
Zhang Chenyu,Tang Jiancheng,Ye Nan,Chen Jing
The construction of anode materials for alkali-ion batteries with high capacity and a long life span is significant and remains challenging. With the increasing interest in vanadium sulfide, V 3 S 4 possesses unique a structure and shows great promise for application in alkali-ion batteries, such as lithium-ion batteries (LIBs), sodium-ion batteries (SIBs), and potassium-ion batteries (PIBs). However, it still faces the problems of large volume changes and low electronic conductivities, which limits its practical application. Herein, ultrafine V 3 S 4 nanocrystals evenly integrated within three-dimensional (3D) porous N-doped carbon (N–C) by V–C bond are rational designed to address these issues. The interconnected N–C coating provides bi-continuous electron/ion transport pathways. Also, the 3D porous structure ensures a large surface area, as well as robust structural integrity, boosting reaction kinetics. Moreover, the strengthened interface coupling not only enhances the electron transfer at the interface, but also markedly strengthens structural stability. As expected, the as-prepared electrode showed superior lithium storage capacity, including a high specific capacity of 1021 mA h g −1 at 0.1 A g −1 , superior rate performance of 698 mA h g −1 at 2.0 A g −1 and excellent cycling stability and prolonged cycling stability of 635 mA h g −1 capacity retention over 2000 cycles at 2 A g −1 . Additionally, it also shows good electrochemical performance as an anode material for SIBs and PIBs. This work demonstrates the superiority of ultrafine crystal confined in a 3D porous carbon network to boost the electrochemical performance in various fields.
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RARE METALS
·
2023
·Vol. 42
·期 8
·2592-2600
·
IF 8.8
Chen Jing,Chen Xuan-Le,Lu Rou,Li Yong,Pan An-Qiang
Molybdenum dioxide has aroused a wide concern as anode material for lithium-ion batteries (LIBs) due to its high theoretical capacity and high density. However, it still faces the problems of large volume changes and low electronic conductivities, which limits its practical application. Herein, necklace-like N-doped carbon nanofibers encapsulating MoO 2 nanospheres (MoO 2 @NCNFs) with Mo–C bonding have been designed to address these issues. The rational design carbon coating structure can not only enhance the electron transfer, but also markedly strengthen structural stability. As expected, the as-prepared electrode showed superior lithium storage capacity, including a high specific capacity of 1120 mAh·g −1 at 0.1 A·g −1 , and good rate performance of 502 mAh·g −1 at 4.0 A·g −1 and a prolonged cycling stability of 490 mAh·g −1 capacity retention over 3000 cycles at 4.0 A·g −1 . Graphical abstract
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Materials Today Chemistry
·
2023
·
IF 7.3
S.Y. Fan,X.L. Xu,W.J. Wu
The utilization of quasi-solid conducting medium possessing superior interfacial properties represents a significant approach in tackling the issue of leakage and stability in supercapacitors . However, preserving the conductivity of ions like Li + and enabling their adaptability to high-temperature environments pose significant challenges to the improvement of water-locking capacity. Herein, a bimodal cross-linked hydrogel with a mesoporous structure has been developed based on the polyacrylamide-lithium chloride (PAM-LiCl) hydrogel system using polyethylene glycol (PEG). This hydrogel not only exhibits a high water-binding capacity but also facilitates the migration of Li-ions. Using activated carbon as the electrode material, the assembled quasi-solid state supercapacitor devices achieve a single electrode specific capacitance of 32.6 F/g at 0.1 A/g and an energy density of 1.77 W h/kg by varying the ratio of acrylamide and polyethylene glycol (AM/PEG). The findings of this study demonstrate that utilizing a bimodal cross-linked hydrogel can enable the operation of a supercapacitor at high temperatures above 140 °C.
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DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 26
·9084-9089
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IF 4
Xiaodong Feng,Lihui Liu,Yeming Wang,Chaoqun Zhang,Gang Liu,Yuyang Tian,Guangshan Zhu
A hierarchical metal–organic framework, H-mMOF-1 (representing hierarchical medi-MOF-1), was successfully synthesized by the coassembly of MOF starting reagents and a triblock copolymer surfactant F127. The obtained H-mMOF-1 retained its microporous structure but also exhibited mesopores with a size range from 3 to 10 nm. The mesopores were able to accommodate protein Cyt c with a loading capacity of 160 mg g−1. The surfactant-assisted synthesis of hierarchical MOFs provides promising applications for enzyme immobilization.
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Nature Photonics
·
2023
·Vol. 17
·期 8
·694-701
·
IF 35
Mutailipu Miriding,Han Jian,Li Zhi,Li Fuming,Li Junjie,Zhang Fangfang,Long Xifa,Yang Zhihua,Pan Shilie
Phase-matching of light waves is a critical condition for maximizing the efficiency of nonlinear frequency conversion processes in nonlinear optical crystals; however, phase-matching, commonly achieved by tuning birefringence, is often difficult to achieve over a wide wavelength range. Here, full-wavelength phase-matching crystals that can avoid phase-mismatching across the entire optical transparency range are proposed. The anisotropic strength of bonding in the dimension of energy is confirmed theoretically to be the key to the full-wavelength phase-matching ability. We demonstrate that a crystal of guanidinium tetrafluoroborate (C(NH 2 ) 3 BF 4 ) can be phase-matched throughout its entire optical transparency range and is able to generate harmonic light as short as ~193.2 nm, which is close to its deep-ultraviolet cut-off edge. Importantly, this crystal is stable, cheap and efficient compared with commercially available nonlinear optical crystals for generation of 266 nm light. This work lays the foundation for finding a new class of crystals in which the phase-matching wavelength fully covers its optical transparency range, and also provides a high-performance crystal for generating light at 266 nm—the fourth-harmonic of a commercial 1,064 nm laser.
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JOURNAL OF INORGANIC BIOCHEMISTRY
·
2023
·
IF 3.9
Yan-Yan Li,Shuang-Shuang Long,Lu Yu,Ao-Kun Liu,Shu-Qin Gao,Xiangshi Tan,Ying-Wu Lin
The sequence and structure of human cytochrome c ( h Cyt c ) exhibit evolutionary conservations, with only a limited number of naturally occurring mutations in humans. Herein, we investigated the effects of the naturally occurring S47F/A mutations on the structure and function of h Cyt c in the oxidized form. Although the naturally occurring S47F/A mutations did not largely alter the protein structure, the S47F and S47A variants exhibited a small fraction of high-spin species. Kinetic studies showed that the peroxidase activity of the variants was enhanced by ∼2.5-fold under neutral pH conditions, as well as for the rate in reaction with H 2 O 2 , when compared to those of wild-type h Cyt c . In addition, we evaluated the interaction between h Cyt c and human neuroglobin ( h Ngb) by isothermal titration calorimetry (ITC) studies, which revealed that the binding constant was reduced by ∼8-fold as result of the mutation of the hydrophilic Ser to the hydrophobic Phe/Ala. These findings provide valuable insights into the role of Ser47 in Ω-loop C in sustaining the structure and function of h Cyt c .
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CARBON
·
2023
·
IF 10.9
Jiali Chen,Lei Wang,Bin Shen,Wenge Zheng
Recently, highly efficient electromagnetic attenuation materials are crucial for the development of modern electronics and telecommunications. Meanwhile, biomass-derived carbon materials have attracted widespread attention due to their availability and renewable characteristics. In this study, a composite with Co/C particles embedded in carbon networks was synthesized by pyrolysis of cotton fiber coated with ZIF-67, which are showing tunable and higher electromagnetic interference (EMI) shielding effectiveness (SE) than pure carbon networks. The remarkable performance originated from the aligned carbon networks and the Co/C particles connected by the carbon networks. The former can achieve the regulation of EMI SE by changing the angle between the fiber orientation direction and the direction of the incident EM-wave electric field, while the latter can play a role in catalytic graphitization and enhance the shielding performance. When decreasing the pyrolysis temperature and filling the composite powder with 30 wt% in the paraffin matrix, the minimum reflection loss (RL min ) can reach −58.8 dB at 5.12 mm. In addition, the effective absorption band (EAB) of the composite can cover the C-Ku band by adjusting the thickness from 3 to 7 mm. This work provides a potential guideline for efficient biomass-based electromagnetic attenuation materials.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Xiang Qin,Yunkang Ji,Lijuan Nong,Chendi Wang,Huiting Li,Chunyu Xie,Lijun Ji,Aiping Zhu
C/Ti 3 C 2 /(001)TiO 2 hollow microspheres were prepared by combining the template method, self-assembly and hydrothermal method . Anatase TiO 2 nanosheets with rich oxygen vacancies formed on the microspheres and exposed active (001) facets due to the spherical surface. TC was removed 92.3% by C/Ti 3 C 2 /(001)TiO 2 -HMs within 160 min, 28.4% by TiO 2 and 49.5% by (001)TiO 2 /Ti 3 C 2 under the same condition. The high removal efficiency of C/Ti 3 C 2 /(001)TiO 2 -HMs could be because the oxygen vacancies exposed on the surface of (001)TiO 2 afforded more active sites, extended the light absorption range and promoted the generation of electron-hole pairs. The composite C/Ti 3 C 2 /(001)TiO 2 structure could suppress the recombination of electron-hole pairs and prolong their lifetime. The degradation pathway of TC was discussed. The TC removal efficiency of C/Ti 3 C 2 /(001)TiO 2 -HMs was confirmed by treating the wastewater from the Slender West Lake. The production principle of oxygen vacancy could be used for preparing MXene composites with excellent catalytic properties and the C/Ti 3 C 2 /(001)TiO 2 -HMs could be a potential choice for treating wastewater.
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