PEST MANAGEMENT SCIENCE
·
2023
·
IF 4.1
Tianze Li,Min Lv,Houpeng Wen,Jiawei Du,Zhen Wang,Shaoyong Zhang,Hui Xu
Background Phytopathogenic fungi can cause a direct loss in economic value of agriculture. Especially Valsa mali Miyabe et Yamada, a devastating phytopathogenic disease especially threatening global apple production, is very difficult to control and manage. To discover new potential antifungal agents, a series of thiosemicarbazone derivatives of 3-acetyl- N -benzylindoles were prepared. Their antifungal activities were first tested against six typically phytopathogenic fungi including Curvularia lunata , Valsa mali , Alternaria alternate , Fusarium graminearum , Botrytis cinerea and Fusarium solani . Then their mechanism of action against V. mali was investigated. Results Derivatives displayed potent antifungal activity against V. mali . Notably, 3-acetyl- N -benzylindole thiosemicarbazone (IV-1: EC 50 : 0.59 μ g mL −1 ), whose activity was comparable to that of a commercial fungicide carbendazim (EC 50 : 0.33 μ g mL −1 ), showed greater than 98-fold antifungal activity of the precursor indole. Moreover, compound IV-1 displayed good protective and therapeutic effects on apple Valsa canker disease. By scanning electron microscope (SEM) and RNA-Seq analysis, it was demonstrated that compound IV-1 can destroy the hyphal structure and regulate the homeostasis of metabolism of V. mali via the ergosterol biosynthesis and autophagy pathways. Conclusion 3-Acetyl- N -(un)substituted benzylindoles thiosemicarbazones (IV-1–IV-5) can be studied as leads for further structural modification as antifungal agents against V. mali . Particularly, these ergosterol biosynthesis and autophagy pathways can be used as target receptors for design of novel green pesticides for management of congeneric phytopathogenic fungi. © 2023 Society of Chemical Industry.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2025
·Vol. 13
·期 35
·29450-29460
·
IF 9.5
Yushen Qian,Mengxue Wu,Anyu Hu,Honghao Deng,Nawal K. Almaymoni,Abdullah N. Alodhayb,Jie Li,Jiahong Pan,Ping Chen,Zhicong Shi
Sodium iron sulfate (Na2+2xFe2−x(SO4)3, NFS) is a promising cathode material for sodium-ion batteries (SIBs) for large-scale energy storage systems due to its low cost and long life. However, NFS is an insulator and cannot reversibly store sodium ions to a large extent. To address this problem, an NFS material integrated with carbon nanotubes (CNTs) is developed in this work. The incorporation of CNTs effectively converts NFS from an insulator to a semiconductor, thereby significantly enhancing the electrochemical performance. The NFS@CNTs material incorporates an alluaudite-type framework that improves electronic conductivity, thereby enhancing rate capability and cycling life. By introducing 10 wt% CNTs, the NFS@CNTs composite achieves a high working voltage of 3.8 V (vs. Na/Na+) and an impressive high-rate specific capacity of 80 mA h g−1 at a rate of 20C. Furthermore, it can retain 81.4% of the initial specific capacity after 20 000 cycles at a rate of 50C, demonstrating an outstanding cycling stability. This work not only provides an in-depth understanding of the potential of NES to be used as a high-rate, long-lasting cathode material for SIBs but also lays the foundation for SIBs in large-scale energy storage applications.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 36
·2307
·
IF 2.8
Zhang Huayushuo,Ma Qian,Gao Pan,Li Bolong,Yang Xiaoxia,Li Chao,Song Mingming,Hou Zhiwei,Jiang Xiaomei
X-ray detection has extensive applications in medical imaging, scientific research, and security inspection. Despite the superior radiation detection properties of lead-based perovskites, including high carrier mobility and superior attenuation efficiency, their toxicity and instability arising from ion migration hinders further development. To address these challenges, a series of halogen-tuned lead-free 3-methylpiperidine bismuth halides, (C 6 H 14 N) 3 Bi 2 I 9 , (C 6 H 14 N) 2 BiBr 5 and (C 6 H 14 N) 2 BiCl 5 (C 6 H 14 N = 3-methylpiperidine) single crystals were grown and systematically characterized. 3-methylpiperidine was selected for its steric effect stabilizing the lattice, and the synergistic tuning through halogen variation enabled a structural transition along with modulation of their properties. Notably, the lateral-structured (C 6 H 14 N) 3 Bi 2 I 9 single-crystal X-ray detector exhibits a sensitivity of 388.05 μC Gy −1 cm −2 , a low detection limit of 71.05 nGy s −1 , and a small dark current drift of 2.16 × 10 –8 nA cm −1 s −1 V −1 . Importantly, this material retains its original morphology after 8 months of storage in ambient conditions. Furthermore, flexible X-ray devices fabricated via spin-coating (C 6 H 14 N) 3 Bi 2 I 9 exhibited a favorable X-ray response with a sensitivity of 121.48 μC Gy −1 cm −2 , as well as excellent mechanical stability. This work reveals that halogen tuning effectively optimizes the structure and performance of Bi-based perovskites, providing valuable insights for advancing them in X-ray detection applications.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Optical Materials
·
2025
·
IF 3.8
Huan Zhou,Meng Cheng,Zhihua Yang,Shilie Pan
Birefringent materials are crucial optical materials that enable the control of polarized light in optical technologies, yet achieving high birefringence in systems dominated by non-π-conjugated units in the deep-ultraviolet (UV) region remains a significant challenge. Herein, a birefringent material, [C(NH2)3]2PO3(OH), was successfully synthesized by integrating π-conjugated [C(NH2)3] units and heteroleptic tetrahedra [PO3(OH)]. The short UV cutoff edge (<200 nm) and large birefringence (0.086 @ 546 nm) make [C(NH2)3]2PO3(OH) a potential deep-UV birefringent crystal. This study provides the experience for the design of deep-UV optical crystals.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Qian Zhang,Qianrui Yang,Tianci Liu,Yuchen Yue,Jingran Zhang,Guifu Zuo
In this work, a novel Faraday cage-type electrochemiluminescence (ECL) biosensor was constructed for the ultrasensitive "turn on" detection of CEA. The capture unit was prepared by immobilizing the Carcinoembryonic antibody Ab 1 onto the functionalized magnetic Fe 3 O 4 nanoparticles, while the detection unit consisted of modified g-C 3 N 4 labeled with antibody Ab 2 . The recognition scaffold was assembled as follows: the capture unit was first fixed onto the magnetic electrode surface; the target CEA was then captured; followed by further hybridized with the detection unit; ultimately forming the Faradaycage biosensor structure. In this configuration, the signal unit became part of the electrode surface, enabling all electrochemiluminophores in the signal unit to participate in the electrode reaction, thereby significantly enhancing the detection sensitivity. Utilizing the proposed Faraday-cage cascade, the ECL intensity increased with the rising CEA concentration. The linear range was from 0.01 to 100 ng/mL, with a detection limit of 0.35 pg/mL. The sensor was validated for its selectivity, stability, reproducibility, precision, and application potential. This Faraday cage-type ECL biosensor shows promising prospects for clinical CEA detection.
✓ 已验证
产品关联
DOI
高影响因子
ChemCatChem
·
2025
·
IF 3.9
KunShan Ouyang,Mengyuan Qu,Liyan Xie,Zhishan Luo,Jianqin Chen,Jianhui Huang
CdIn 2 S 4 /In(OH) 3 heterojunctions were constructed via a scalable ultrasonic spray pyrolysis method combined with H 2 O 2 -enabled in situ etching, in order to address the issues of photocorrosion, scarce active sites, and rapid charge recombination observed in pristine CdIn 2 S 4 . The optimized heterojunction, achieved using 50 µL of H 2 O 2 , demonstrates a significantly enhanced H 2 evolution rate of 736 µmol g −1 h −1 , which is 12 times greater than that of pristine CdIn 2 S 4 , along with stable performance throughout three consecutive catalytic cycles. Structural and chemical analyses verify the formation of a closely integrated heterojunction interface, which facilitates improved charge separation and efficient electron transfer from CdIn 2 S 4 to In(OH) 3 , as further corroborated by electrochemical and photoluminescence studies. A possible mechanism for hydrogen evolution is also proposed. Graphical Constructing CdIn 2 S 4 /In(OH) 3 heterojunctions via in situ etching achieves a 12-fold enhancement in photocatalytic H 2 evolution with excellent stability, by enabling efficient electron transfer and charge separation.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2025
·
IF 1.6
Zhao Fan,Zhang Wei,Chen Yuantao
The zinc-based metal–organic framework (IRMOF-3) was assembled on the surface of Galdieria sulfuraria (Gs) via a one-pot method to fabricate the composite adsorbent Gs/IRMOF-3. Results show that the material achieves optimal adsorption performance at pH = 6. The adsorption process follows the Freundlich isotherm model and pseudo-second-order kinetic model, demonstrating that it is dominated by multi-molecular layer chemical adsorption and represents a spontaneous endothermic process. This study provides a novel strategy for developing efficient and eco-friendly uranyl adsorption materials.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Functional Foods
·
2021
·
IF 4.451
Yaozhong Hu,Jiaxin Gu,Jing Lin,Yi Wang,Feier Yang,Jia Yin,Zhenting Yu,Sihao Wu,Huan Lv,Xuemeng Ji,Shuo Wang
The intervention of EGCG on M1/M2 macrophage polarization was still unclear and should be studied comprehensively. In this context, the intervention of EGCG on macrophage polarization has been investigated to reveal that EGCG promoted M2 polarization of RAW264.7 upon treating with EGCG. A significant inhibitory effect of EGCG on M1 polarization was observed upon stimulating with LPS and IFN-γ. The expression of macrophage phenotype related marker genes (iNOS, COX-2, IL-1β for M1; Arg-1, Ym-1, IL-10 for M2) demonstrated the suppression of M1 polarization and the promotion of M2 polarization in liver, colon, spleen, and brain. Further analysis against peritoneal macrophages verified the increased M2 phenotypes and decreased M1 macrophages, and the similar variation in liver were confirmed by immunohistochemistry (IHC). No significant variation of spleen macrophages was observed with the general macrophages in declined tendency. Bio-distribution of EGCG and its metabolites (EGC, GA) in different organs has been further determined.
✓ 已验证
DOI
高影响因子
ACS Chemical Neuroscience
·
2022
·
IF 5.78
Qianlei Zhao,Tingting Chen,Chao Ni,Yingying Hu,Yan Nan,Wei Lin,Yanli Liu,Feixia Zheng,Xulai Shi,Zhongdong Lin,Jianghu Zhu,Zhenlang Lin
The blood–brain barrier (BBB) is an important physiological barrier of the human body contributing to maintaining brain homeostasis and normal function. Hypoxic-ischemic (HI)-related brain injury is one of the main causes of neonatal acute morbidity and chronic disability. The previous research of our group confirmed that there was serious BBB destruction during HI brain injury. However, at present, the protection strategy of BBB is very limited, and further research on the protection mechanism is warranted. Indole-3-propionic acid (IPA) is a bacterial metabolism with anti-inflammatory and antioxidant properties, having neuroprotective effects and protective effects on the mucosal barrier. However, the role of IPA in BBB is not clear. In this research, we demonstrated the protective effect of IPA on BBB disruption from HI brain injury and hypothesized that it involves the amelioration of inflammation, oxidative stress, and MMP activation, thereby inhibiting apoptosis of rat brain microvascular endothelial cells (rBMECs). We demonstrated that expression levels of several inflammatory markers, including iNOS, TNF-α, IL-6, and IL-1β, were significantly increased from HI damage or OGD injury. However, IPA treatment inhibited the increase significantly. Moreover, we demonstrated that IPA reduced intracellular ROS levels and MMP activation in rBMECs from OGD injury. Further research on the underlying detailed molecular mechanisms suggested that IPA attenuates inflammation by inhibiting NF-κB signaling. Finally, we investigated the mechanism of the relationship between PXR activation and NF-κB inhibition. The results suggested overexpression of PXR in rBMECs could significantly counteract the decrease of junction proteins and downregulate the increased p-IκB-α and p-NF-κB from OGD injury. However, the protective effects of IPA were reversed by antagonists of the PXR. Taken together, IPA might mitigate HI-induced damage of the BBB and the protective effect may be exerted through modulating the PXR signaling pathway.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 6.054
Xia Yao,Xiuyun Sun,Shuyu Jin,Ling Yang,Hongjiang Xu,Yu Rao
A structure-hopping strategy was applied to discover a series of novel 4-aminoquinoline-3-carboxamide derivatives as potent, reversible BTK inhibitors. Compared to the previously described cinnoline scaffold compounds, the 4-aminoquinoline analogues showed significantly improved drug-like properties, especially in their aqueous solubility. The most potent compound, 25, displayed a stronger inhibitory effect on both BTKWT (IC50 = 5.3 nM) and BTKC481S (IC50 = 39 nM). In a rodent collagen-induced arthritis model, compound 25 efficiently reduced paw swelling without a loss in body weight. On the basis of potency, drug-like properties, stability, and noncovalent mode of inhibition, our representative inhibitors could have a promising profile to be treatments for a wide range of autoimmune diseases.
✓ 已验证
DOI
PubMed
高影响因子
BRITISH JOURNAL OF PHARMACOLOGY
·
2022
·Vol. 179
·期 12
·3078-3095
·
IF 9.473
Senlin Li,Hong Zhou,Mengyuan Xie,Zijun Zhang,Jing Gou,Jian Yang,Cheng Tian,Kun Ma,Cong-Yi Wang,Yi Lu,Qing Li,Wen Peng,Ming Xiang
Background and Purpose Tacrolimus a first-line medication used after transplantation can induce β-cell dysfunction, causing new-onset diabetes mellitus (NODM). Regenerating islet-derived protein 3 gamma (Reg3g), a member of the pancreatic regenerative gene family, has been reported to improve type 1 diabetes by promoting β-cell regeneration. We aim to investigate the role of Reg3g in reversing tacrolimus-induced β-cell dysfunction and NODM in mice. Experimental Approach Circulating REG3A (the human homologue of mouse Reg3g) in heart transplantation patients treated with tacrolimus was detected. The glucose-stimulated insulin secretion and mitochondrial functions, including mitochondria membrane potential (MMP), mitochondria calcium, ATP production, oxygen consumption rate and mitochondrial morphology were investigated in β-cells. Additionally, effects of Reg3g on tacrolimus-induced NODM in mice were analysed. Key Results Circulating REG3A level in heart transplantation patients with NODM significantly decreased compared with those without diabetes. Tacrolimus down-regulated Reg3g via inhibiting STAT3-mediated transcription activation. Moreover, Reg3g restored glucose-stimulated insulin secretion suppressed by tacrolimus in β-cells by improving mitochondrial functions, including increased MMP, mitochondria calcium uptake, ATP production, oxygen consumption rate and contributing to an intact mitochondrial morphology. Mechanistically, Reg3g increased accumulation of pSTAT3(Ser727) in mitochondria by activating ERK1/2-STAT3 signalling pathway, leading to restoration of tacrolimus-induced mitochondrial impairment. Reg3g overexpression also effectively mitigated tacrolimus-induced NODM in mice. Conclusion and Implications Reg3g can significantly ameliorate tacrolimus-induced β-cell dysfunction by restoring mitochondrial function in a pSTAT3(Ser727)-dependent manner. Our observations identify a novel Reg3g-mediated mechanism that is involved in tacrolimus-induced NODM and establish the novel role of Reg3g in reversing tacrolimus-induced β-cell dysfunction. Graphical
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 20
·1-10
·
IF 2.8
Liu Hao,Wang Yiping,Wang Jiakang,Yang Ying,Liu Huihui,Wu Jintao,Zhang Jiyang
Temperature stability of the piezoelectric ceramics is critical to its performance in high-power devices. In this research, 5 mol% BiScO 3 (BS) is introduced into 0.05Pb(Mn 1/3 Sb 2/3 )O 3 –Pb(Zr 1− x Ti x )O 3 system. The morphotropic phase boundary (MPB) has been re-located by shifting Zr/Ti ratio systematically for the piezoceramic. Optimal piezoelectric properties with piezoelectric coefficient d 33 of 341 pC/N, electromechanical coupling factor ( k p ) of 0.51, and mechanical quality factor Q m value of 859 are obtained in MPB compositions of 0.05BiScO 3 –0.05Pb(Mn 1/3 Sb 2/3 )O 3 –0.9Pb(Zr 45.5 Ti 54.5 )O 3 ceramic at room temperature. Furthermore, the addition of BiScO 3 effects profoundly on the temperature dependence of the piezoelectric and ferroelectric properties. Comparing to common Pb(Zr, Ti)O 3 -based piezoceramic, the BS-doped ceramic presents elevating ferroelectric polarization with temperature up to 200 °C, as well as stabilized d 33 , k p , and Q m values from room temperature to 120 °C.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）