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NPG Asia Materials · 2026 · IF 9

PDA@CeMn nanozyme for enhanced myocardial protection via ROS scavenging and inflammation suppression

Zhou Lanmei,Liu Chang,Song Hui,Li Xinyi,Yuan Yiwen,Jiang Na,Duan Wei,Xu Tianzhao,Liu Xinghui

The mortality rate of cardiovascular diseases (CVD) remains alarmingly high. Studies have shown that reactive oxygen species (ROS)-mediated inflammatory responses and oxidative stress are key pathological mechanisms driving CVD. Nanozymes, nanomaterials with enzyme-like activities, offer several advantages over natural enzymes, including enhanced stability and scalability. Previous research has demonstrated that nanozymes containing cerium (Ce) or manganese (Mn) possess excellent ROS-scavenging capabilities. Dopamine, a positive inotropic agent commonly used in clinical practice to improve cardiac function in patients with heart failure, has also been shown to self.

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JOURNAL OF MEMBRANE SCIENCE · 2026 · IF 8.8

Light-trapping Janus nanofibrous membranes with surface-confined PDA for photothermal membrane distillation

Jun Yu,Jingjing Lei,Jingge Ju,Yanfei Chen,Weimin Kang

A Janus nanofibrous membrane was fabricated via sequential electrospinning. • Fiber light trapping enhanced solar absorption for photothermal conversion. • PDA deposition was optimized to balance mass transfer and photothermal heating. • The membrane achieved 1.97 L m −2  h −1 flux and >99.99% salt rejection. • Stable PMD performance was maintained during 70 h continuous operation. Solar-driven photothermal membrane distillation (PMD) is a promising approach for sustainable desalination, but its practical application is still limited by temperature polarization, membrane wetting, and the trade-off between photothermal conversion and vapor transport. Herein, a polydopamine (PDA)@Janus nanofibrous membrane with asymmetric hydrophilic/hydrophobic architecture was developed by sequential electrospinning and in situ oxidative polymerization of dopamine. The membrane consisted of a hydrophobic polydimethylsiloxane (PDMS)@polystyrene (PS)/thermoplastic polyurethane (TPU) support layer and a hydrophilic poly(m-phenylene isophthalamide) (PMIA)/polyamic acid (PAA) functional layer, with PDA nanoparticles uniformly deposited on the hydrophilic fiber surfaces to construct a fiber-based light-trapping photothermal architecture. The interconnected nanofibrous network promoted multiple light reflections, while the surface-confined PDA coating enhanced light absorption within the measured UV-visible range without substantially blocking the interconnected vapor transport pathways. By systematically regulating dopamine concentration and polymerization time, the PDA deposition morphology, surface wettability, pore structure, mechanical properties, and photothermal performance were effectively optimized. The optimized PDA@Janus-2.0-12 membrane exhibited a water contact angle of 49.21 ± 2.6°, a tensile strength of 7.70 ± 0.6 MPa, and a stable photothermal response under simulated solar irradiation. Under 1.0 kW m −2 solar irradiation with 35 g L −1 NaCl feed, the membrane achieved a permeate flux of 1.97 ± 0.05 L m −2  h −1 with a salt rejection of >99.99%, while maintaining an average photothermal conversion efficiency of 88.67%. The membrane also maintained stable desalination performance during 70 h of continuous PMD operation. Furthermore, the membrane retained a flux of 1.58 ± 0.04 L m −2  h −1 even at a NaCl concentration of 150 g L −1 , demonstrating excellent tolerance to highly saline feeds. These results demonstrate that the synergistic combination of fiber-based light trapping, PDA interfacial photothermal conversion, and asymmetric Janus architecture effectively balances solar energy utilization, vapor transport, and long-term structural stability, providing a promising strategy for solar-driven desalination of high-salinity NaCl brines; further evaluation toward practical complex high-salinity wastewater will be required in future work. Download: Download high-res image (398KB) Download: Download full-size image

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Advanced Materials Technologies · 2025 · IF 6.2

Bi2WO6@PDA Nanosheet with Near-Infrared Induced Emission for Combinational Photothermal/Photodynamic Therapy

Jia-lin Han,Ming-rui Chen,Si-jia Hao,Nian Li,Fu-bin Wen,Kunyan He,Tao Jin

Traditional tumor treatments have the disadvantages of high side effects, single modality, and high damage to healthy tissues. The combination of photothermal and photodynamic therapy (PTT and PDT) shows great potential in tumor treatment. However, it is a challenge to perform both effective PTT and PDT with a single NIR laser irradiation. In this study, photo-responsive bismuth tungstate (Bi 2 WO 6 ) nanosheets are synthesized by a hydrothermal method, and polydopamine (PDA) with photothermal effect are coated on the surface of Bi 2 WO 6 by in situ polymerization. This nanocomposite has excellent photothermal, photodynamic response under single laser irradiation. Through 808 nm laser irradiation, using the photothermal properties of PDA and the good photocatalytic properties of Bi 2 WO 6 , Bi 2 WO 6 @PDA (0.5 mg mL −1 ) can rapidly heat up (>50 °C) and produce reactive oxygen species, and the killing rate of 4T1 cells reaches ≈90%. The Bi 2 WO 6 @PDA shows good biocompatibility during in vitro cytotoxicity. Thus, Bi 2 WO 6 @PDA can be used for combined PTT and PDT therapy under single NIR laser, providing a reference for multimodal combinational anti-tumor approaches.

CAS / MDL: 10035-06-0 1185-53-1
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DYES AND PIGMENTS · 2025 · IF 4.2

Orthogonal polydiacetylene (PDA) derivatives based optical chemsensors for the selective detection of cyanide

Ke Sun,Zhongquan Zhu,Guowei Li,Yizhi Shao,Heng Xia,Hui Deng,Jianjun Zhang,Jiangang Gao,Gaopeng Shi,Yangyang Xu

Due to its widespread usage but high toxicity, the detection of cyanide has drawn special attention. However, in many works usually only one colorimetric or fluorescent detector was put forward for chemical sensing. Here in this contribution, two kinds of polydiacetylene (PDA) derivatives substituted by either o -hydroxybenzaldehyde or dicyanovinyl group were designed and explored for the optical sensing of cyanide. Firstly, these two PDA derivatives were polymerized in the form of vesicle individually and showed chromatic transition from blue to purple or red after the addition of cyanide into the aqueous solution. Then polyvinylidene fluoride membrane was chosen to incorporate the PDAs to form strip-based solid sensors, which could exhibit obvious blue-to-red colorimetric response upon exposure to cyanide aqueous solution with different concentrations in an orthogonal way. Interestingly, these two PDA derivatives remained blue phase in the presence of many common anions, thus demonstrating excellent selectivity for the distinguishment of cyanide. Besides the experimental characterization methods, such as UV–visible absorption and Raman spectroscopy, to study the underlying chemical mechanism, the principal component analysis method was also applied for the multivariate statistical analysis in combination with RGB (Red, Green, Blue) values to obtain a deep insight into the chromatic sensing of PDAs.

研究领域: 化学传感 · 材料科学
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS · 2024 · IF 4.9

Tetraaniline-modified Co-MOF-PDA for anti-corrosive reinforcement of waterborne epoxy coating

Dan Sun,Qilong Chen,Yi He,Yang Bai,Changhua Li,Rui Gou,Chuanfang Zhang,Xinbo Xu,Haichao Zhang

The main aim of this study was to exploit the advantages of dopamine and tetraaniline (TA) to enhance the physical barrier properties and active anti-corrosion performance of composite coatings ; in this study, the growth of polydopamine on the surface of Co-MOF enhanced its compatibility with waterborne epoxy, and Co-MOF-PDA-TA (MP-TA) was successfully synthesised by adding dopamine and tetraaniline via Michael addition , confirmed through characterisation methods such as Fourier-transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy. MP-TA can be added as a nanofiller additive to water-based epoxy coatings, and a detailed study on the corrosion resistance of the prepared composite coatings showed that the composite coating containing 0.50wt% MP-TA/WEC exhibits good anti-corrosion performance with an impedance modulus at low frequency (0.01 Hz) of 7.253 × 10 9 Ω cm 2 because TA not only prolongs the time required for corrosion ions to reach the interface but also forms a passivation film on the steel surface. Moreover, the reduced TA can be oxidised to EB or even LEB by releasing two electrons, which further promotes the formation of a passivation film, providing a good pathway for the application of MP-TA as a multifunctional additive.

研究领域: 材料科学 · 腐蚀与防护
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ACS Applied Polymer Materials · 2024 · IF 4.4

PVDF/Fe3O4@pDA@Ag Nanofiber Membranes with Multicore–Shell Structure for EMI Shielding

Keduo Yan,Lan Xu,Adnan Ahmed

Due to the rapid development of information technology and the trend toward miniaturization of electronic equipment, the research on electromagnetic interference (EMI) shielding materials is rapidly moving toward low-dimensional, core–shell, and lightweight directions, with a wide range of application prospects in various fields. In this study, using pDA as a binder, poly(vinylidene difluoride) (PVDF)/Fe3O4@pDA@Ag nanofiber membranes (NFMs) with a multicore–shell structure were prepared by in situ growth of Ag nanoparticle (NP) layers on the fiber surface of electrospun PVDF/Fe3O4 NFMs fabricated in batch. Compared to PVDF@pDA@Ag NFM, the average EMI shielding efficiency (SE) of PVDF/Fe3O4@pDA@Ag NFM reached 82.31 dB because of the increased hysteresis and multireflection losses inside the NFM caused by the moderate addition of Fe3O4 NPs. In addition, the synergistic effect of Fe3O4 and Ag NPs increased the microwave attenuation and impedance matching of composite NFM, further enhancing its EMI SE.

CAS / MDL: 1336-21-6
研究领域: 材料科学 · 电子工程
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FASEB JOURNAL · 2026 · IF 4.3

Oridonin‐Loaded PDA@Gel@GO Nanocapsules Modulate NLRP3 and Epithelial Repair in Colitis

Wenbo Yuan,Qirui Zhao,Jing Hua,Lingyao Xu,Yufan Wang,Tongtong Xu,Zuchao Du,Liping Wu,Daxiang Cui

Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by sustained mucosal inflammation and epithelial barrier dysfunction, closely associated with aberrant NOD‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasome activation. Targeted oral therapies that simultaneously suppress inflammation and promote mucosal repair remain limited. We developed an orally administrable nanomicrocapsule system (PDA@Gel@GO) for colon‐targeted delivery of oridonin, a natural diterpenoid with anti‐inflammatory activity. The system was constructed by encapsulating galactosylated carboxymethyl chitosan–based oridonin nanomicelles (GO) within gelatin microspheres, followed by polydopamine coating to enhance gastrointestinal stability and mucosal adhesion. In a dextran sulfate sodium (DSS)‐induced UC mouse model, PDA@Gel@GO exhibited preferential accumulation in inflamed colonic tissues and significantly improved body weight loss, disease activity index, and colon shortening. Mechanistic studies demonstrated that PDA@Gel@GO treatment suppressed NLRP3 inflammasome activation, as evidenced by reduced expression of NLRP3, ASC, caspase‐1, and IL‐1β, accompanied by attenuation of oxidative stress and restoration of intestinal barrier proteins. Transcriptomic analysis further revealed activation of gene programs associated with epithelial regeneration, cell cycle progression, and DNA repair, suggesting coordinated inflammation resolution and mucosal repair. Collectively, this study presents a macrophage‐targeted, multilayered nanomicrocapsule platform that enhances the therapeutic efficacy of oridonin through precise colon targeting and integrated anti‐inflammatory and tissue‐protective effects, providing a promising strategy for precision treatment of UC. Mechanism of galactosylated carboxymethyl chitosan nanomicelle oral microcapsules delivering oridonin in alleviating colitis via targeting the NLRP3 inflammasome.

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TRIBOLOGY INTERNATIONAL · 2026 · IF 6.9

Multifunctional PDA@Fe nanoparticles enable a synergistic-adhesive and supportive lubricating film underwater

Chaobao Wang,Binlu Zhang,Jianzhe Huang,Jiale Chen,Yuyang Xi,Xinqi Zou

The mussel-inspired adhesion of polydopamine (PDA) provides a possibility for the formation of transferring lubrication films underwater. However, the inherent softness of PDA film limits its application in heavy-load lubrication situation. Therefore, a series of PDA@Fe core–shell nanoparticles were synthesized and their wettability and lubrication performance were evaluated. Compared to bare 304 stainless steel, the water contact angle of the PDA@Fe nanoparticle-coated surface is reduced from 86° to 48°. Tribological tests on steel–steel friction pairs show that, compared with deionized water, the PDA@Fe suspension reduces the friction coefficient and wear rate by up to 28.5 % and 56.6 %, respectively. Furthermore, EDS analysis reveals that PDA@Fe nanoparticles adhere to the worn surface and form a synergistic-adhesive and supportive lubricating film, in which Fe nanoparticles provide mechanical support and enhance PDA adhesion through ionic chelation. PDA, in turn, contributes hydration lubrication. This synergy results in highly efficient friction and wear reduction, suggesting that the multifunctional PDA@Fe nanoparticles offer an eco-friendly and durable solution for water-lubricated systems.

CAS / MDL: 62-31-7
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ACS Applied Materials & Interfaces · 2020 · IF 8.758

Synthesis of PDA-Mediated Magnetic Bimetallic Nanozyme and Its Application in Immunochromatographic Assay

Xiaocui Lai,Ganggang Zhang,Lifeng Zeng,Xiaoyue Xiao,Juan Peng,Ping Guo,Wei Zhang,Weihua Lai

Immunochromatographic assay (ICA) is widely applied in various fields. However, severe matrix interference and weak signal output present major challenges in achieving accurate and ultrasensitive detection in ICA. Here, a polydopamine (PDA)-mediated magnetic bimetallic nanozyme (Fe3O4@PDA@Pd/Pt) with peroxidase-like activity was synthesized and used as a probe in ICA. The magnetic property of Fe3O4@PDA@Pd/Pt enabled effective magnetic enrichment of targets, thereby reducing the matrix interference in the sample. PDA coating on the magnetic bimetallic nanozyme was employed as a mediator and a stabilizer. It improved the catalytic ability and stability of the magnetic bimetallic nanozyme by providing more coordination sites for Pd/Pt growth and functional groups (−NH and −OH). In addition, the Pd/Pt bimetallic synergistic effect could further enhance the catalytic ability of the nanozyme. A method was developed by integrating Fe3O4, PDA, and Pd/Pt into Fe3O4@PDA@Pd/Pt as a probe in ICA. With the proposed method, human chorionic gonadotropin and Escherichia coli O157:H7 were successfully detected to be as low as 0.0094 mIU/mL in human blood serum and 9 × 101 CFU/mL in the milk sample, respectively. This method may be readily adapted for accurate and ultrasensitive detection of other biomolecules in various fields.

研究领域: 生物医学工程 · 分析化学
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DIAMOND AND RELATED MATERIALS · 2021 · IF 3.315

Thermal conductivity and electrical insulation properties of h-BN@PDA/silicone rubber composites

Xiaoyu Zhang,Juan Yi,Yanan Yin,Yiheng Song,Chuanxi Xiong

In recent years, with the increasing demands of portable and high-speed electronic devices, highly integrated equipment attracts people's attention more and more. However, it is a great challenge to guarantee the long-term stability of electronic products at high temperatures. Hexagon boron nitride (h-BN), which owned excellent thermal conductivity and insulation properties , was preferred for electronics. For better compatibility of inorganic fillers and silicone rubber, a biological modification by coating polydopamine (DA) on h-BN was adopted. Herein, the composites based on h-BN@PDA and silicone rubber were fabricated. Compared with h-BN/silicone rubber composites , the thermal conductivity of h-BN@PDA/silicone rubber composites increased and volume resistance of materials had been decreasing. When the amount of h-BN@PDA fillers was 30 wt%, the thermal conductivity of h-BN@PDA/silicone rubber composite increased to 0.95 W m −1  K −1 . The volume resistivity of 30 wt% h-BN@PDA/silicone rubber composite reached 2.5 × 10 11  Ω·cm, which was the lowest one among others, which still exceeded requirements of electronic materials.

CAS / MDL: 110-82-7 62-31-7 77-86-1
研究领域: 材料科学 · 电子工程
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REACTIVE & FUNCTIONAL POLYMERS · 2020 · IF 3.333

Fabrication of PDA@SiO2@rGO/PDMS dielectric elastomer composites with good electromechanical properties

Leipeng Liu,Ying Lei,Zhicheng Zhang,Jinru Liu,Shenghua Lv,Ziyi Guo

Since dielectric elastomers (DEs) can undergo muscle-like actuation under external electric fields, they show promising applications in fields such as actuators, generators, and biomimetic robots. However, traditional DEs require strong electric fields and pre-stretching to deliver useful deformation, limiting their practical applications. Herein, a novel method for preparing polydimethylsiloxane (PDMS) composites with high actuation under low electric field without pre-stretching is reported. In this method, polydopamine (PDA) is used to modify sandwich-structured silicon dioxide@graphite oxide hybrids (PDA@SiO 2 @GO). The inclusion of the SiO 2 layer improves the dielectric constant and reduces the dielectric loss of the composite, while the PDA shell improves the dispersibility of the filler. The PDA@SiO 2 @rGO/PDMS composite containing 5 wt% PDA@SiO 2 @GO exhibits a large actuated strain of 14.23% under an electric field of 33.19 kV/mm without pre-stretching; this value is 465% larger than that of pure PDMS and superior to those of most reported DEs composites. The results provide a promising new route to prepare high-performance DEs.

研究领域: 材料科学 · 智能材料 · 仿生机器人
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CELLULOSE · 2018 ·Vol. 26 ·期 2 ·1355-1366 · IF 3.809

PDA-assisted one-pot fabrication of bioinspired filter paper for oil–water separation

Tang Xinde,Wang Xuefei,Tang Chao,Ma Jianpeng,Zhang Suyuan,Li Zhanfeng,Dong Fuying

Abstract Inspired by the robust and durable adhesion of mussels, highly hydrophobic filter paper was fabricated by a polydopamine (PDA)-assisted one-pot procedure using silica nanoparticles and silane coupling agent (hexadecyltrimethoxysilane, HDTMS) as coating materials at ambient temperature. The surface chemistry, morphology, and hydrophobicity of the coated filter paper were measured by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, atomic force microscope, scanning electron microscopy, and water contact angle. The capacity, durability, and recyclability of the coated filter paper were evaluated by the separation of oil–water mixtures and emulsions. The coated filter paper is highly hydrophobic with a water contact angle of > 130°. The coatings with enhanced adhesion to the substrate resisted mechanical abrasion without significant loss of hydrophobicity, which suggested that PDA plays a crucial role in improving the adhesion of silica nanoparticles to the paper surface. The coated filter paper showed high oil–water separation efficiency up to 95%, and maintained high hydrophobicity after recycling over 10 cycles. The coated filter paper that is based on a simple, low cost, and environmentally friendly procedure exhibits potential for applications in oil-recovery and oil–water separation materials. Graphical Abstract

研究领域: 材料科学 · 环境科学
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