Human Cell
·
2025
·Vol. 38
·期 6
·1-17
·
IF 3.1
Li Qingsheng,Liu Yuxi,Zhang Lin,Zheng Yi,Feng Xiaofan,Wang Yanjie
The occurrence of tumor metastasis is associated with the phenotype of tumor-associated macrophages (TAMs). Within the tumor microenvironment, TAMs undergo metabolic reprogramming. Aerobic glycolysis contributes to TAM polarization into an M2-like phenotype. Cedrol is a component extracted from herbal medicines. Anti-cancer activities of cedrol have been reported, however, its effect on the metabolic reprogramming and pro-metastatic ability of TAMs remains unclear. Here, we found that cedrol reduced THP-1-derived macrophage polarization into M2-like phenotypes. Cedrol impaired the promoting effects of TAMs on the migration and invasion of lung cancer cells. Tumor metastasis in C57BL/6 mice was reduced following cedrol treatment, accompanied by decreases in M2-like TAMs in the lung tissues. Cedrol treatment decreased glucose consumption and lactate production and downregulated glycolysis-associated gene expression. A glycolytic inhibitor (2-DG) was utilized to confirm that suppression of glycolysis in TAMs limited the metastasis of lung cancer cells. MYC was identified as a downregulated gene in cedrol-treated TAMs based on the mRNA sequencing analysis. MYC overexpression could reverse the effects of cedrol on TAMs. Cedrol treatment reduced MYC expression at least partly via the PI3K-Akt pathway. These findings suggest that cedrol exerts anti-tumor effects by inhibiting TAM polarization into an M2-like phenotype by modulating MYC-mediated aerobic glycolysis, indicating cedrol as a potential drug for lung cancer treatment.
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 28
·期 46
·65243-65254
·
IF 4.223
Chen Tao,Cao Zhonghong
To explore the relations between the number of accident deaths (NCD) and various factors in construction safety, a multiple linear regression model was established, based on the panel data of economy, construction labor, and the number of accident deaths in 31 provinces (regions) of China from 2009 to 2018. The results show that the average total profits and taxes (TPAT), and the death rate of ten thousand people (DR) are positively correlated with NCD, while the labor productivity (LP) is negatively correlated with it. Under the condition that other factors remain unchanged, NCD increases by 0.02 per a hundred million CNY. However, if DR increases by one ten thousand, NCD will increase by 8.66 on average. On the contrary, when LP increases by a hundred million CNY per ten thousand people, NCD decreases by 0.19. The model also predicts NCD in different provinces and cities from 2019 to 2020 with the method of quadratic exponential smoothing. As well, practice results show that the model is effective and practical.
研究领域:
安全工程
·
建筑工程
·
应用统计学
·
公共安全
·
劳动经济学
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高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2012
·Vol. 113
·期 2
·939-945
·
IF 1.604
Chen Yan,Yang Liting,Wu Jiahui,Ma Lijun,Finlow David E.,Lin Shaoquan,Song Keming
A series of new modified epoxy resin (EP) cured products were prepared from epoxidized soybean oil and commercial epoxy resin, with methyl nadic anhydride as curing agent and 1-methylimidazole as promoting agent. The thermal properties of the resins were characterized by DMA and TG; DSC was used to determine the curing process. Fourier transform infrared spectroscopy was utilized to investigate their molecular structures and scanning electron microscopy was used to observe the micro morphology of their impact fracture surfaces. Tensile and impact testing was employed to characterize the mechanical properties of the cured products. The combination of commercial EP with 20 wt% ESO resulted in a bioresin with the optimum set of properties: 130.5 °C T
g , 396.9 °C T
50 % , 74.89 MPa tensile strength, and 48.86 kJ m −2 impact resistance.
研究领域:
高分子材料
·
复合材料科学
·
生物基聚合物
·
材料化学
·
热固性树脂
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DOI
高影响因子
Early Childhood Education Journal
·
2014
·Vol. 44
·期 1
·1-9
·
IF 0
Jacobi-Vessels Jill L.,Todd Brown E.,Molfese Victoria J.,Do Ahn
Attention to early childhood mathematics instructional strategies has sharpened due to the relatively poor mathematics performance of U.S. students in comparison to students from other countries and research evidence that early mathematics skills impact later achievement. Early Childhood counting skills form the foundation for subsequent mathematics learning. In this article, we discuss the milestones of counting development and examine preschool classroom mathematics observations through the lenses of two CLASS Dimensions, Concept Development and Instructional Learning Formats. Recommendations for effective instructional strategies around counting and suggestions for incorporating mathematics instruction into storybook reading are provided.
研究领域:
学前教育学
·
发展心理学
·
基础教育研究
·
数学教育
·
儿童认知发展
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DOI
IONICS
·
2015
·Vol. 21
·期 7
·1937-1943
·
IF 1.754
Rao Mumin,Li Xiaogang,Liao Youhao,Li Xiaoping,Li Weishan
A novel gel polymer electrolyte (GPE) based on an electrospun polymer membrane of polyimide (PI) activating with poly(vinylidene fluoride- co -hexafluoropropylene) (PVDF-HFP) and further coating with nano-Al 2 O 3 was prepared, and its performance for lithium-sulfur (Li-S) cell was investigated. It is found that the Li-S cell using the new GPE enabled achieving a stable discharge capacity of 820 mAh g −1 after more than 100 cycles. This new GPE system with activating with PVDF-HFP and further coating with nano-Al 2 O 3 was capable of upholding the electrolyte solution and can suppress the dissolution of the intermediate products generated during the discharge process and thus improves the performance of Li-S cell.
研究领域:
材料科学
·
储能技术
·
高分子化学
·
电化学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 24
·28192-28203
·
IF 2.478
Qin Yi,Li Xiaohan,Zhao Ting,Zhu Jianfeng,Yang Yanling,Xie Meiqian
Thermoelectric materials convert thermal energy into electricity directly. Constructing nanostructured composite architectures can be an effective strategy to develop thermoelectric performance. SnSe/Ti 3 C 2 composite materials were synthesized through the electrostatic self-assembly method followed by spark plasma sintering. The interfaces introduced by Ti 3 C 2 can scatter carriers effectively, thus increasing the Seebeck coefficients ( S ), finally, a high absolute S value of ~ 296.2 µV K −1 was obtained at 773 K. At the same time, the high-density interfaces of SnSe/Ti 3 C 2 composites enhance the phonon scattering, a low lattice thermal conductivity k lat of 0.54 W m −1 K −1 was obtained. Benefit from the elevated Seebeck coefficient and decreased thermal conductivity, a ZT of 0.1 was obtained at 773 K along the pressing direction, compared with the pure SnSe, the thermoelectric performance improved by 68%. This research will provide a new way for the development of the thermoelectric properties of polycrystalline SnSe.
研究领域:
材料科学
·
热电学
·
纳米复合材料
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高影响因子
JOURNAL OF CHEMICAL SCIENCES
·
2024
·Vol. 136
·期 4
·82
·
IF 1.7
Qin Xiao-Li,Ding Xue-Qing,Li Yu-Qin,Yu Yi-Hao,Xu Fan,Rong Zhou
A method for synthesizing 3-substituted isocoumarins under copper catalysis involves the cyclization reaction of o -bromobenzoic acid and alkynes in DMSO, with the assistance of K 2 CO 3 at 100 °C. It exhibits a wide range of substrate compatibility and excellent tolerance towards diverse functional groups. Graphical abstract A method for synthesizing 3-substituted isocoumarins under copper catalysis involves the cyclization reaction of o-bromobenzoic acid and alkynes in DMSO, with the assistance of K 2 CO 3 at 100 °C. This reaction demonstrates a synthesis yield of 8–81% for 3-substituted isocoumarins.
研究领域:
有机化学
·
有机合成化学
·
催化化学
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DOI
高影响因子
Science China-Materials
·
2026
·
IF 7.7
He Jiaman,Kang Liwen,Zeng Weigang,Shi Wanxin,Ling Qidan,Lin Zhenghuan
Organic-inorganic hybrid metal halides (OIMHs) based on Cu(I) ions show broad application prospects in the field of stimulus-responsive luminescent materials based on their rich structural diversity and highly adjustable electronic state. However, achieving sensitive and broad-temperature-range thermal responses for OIMHs remains a significant challenge, despite the growing interest in smart luminescence materials. In this study, 4-morpholinopiperidine (4-MP) and CuI are used to synthesize a zero-dimensional warm white-light emitting OIMH, namely MPC-W ((C 9 H 20 N 2 O) 4 (Cu 2 I 4 )(Cu 2 I 6 )(H 2 PO 2 ) 2 ), which features hybrid structures of [Cu 2 I 4 ] 2− and [Cu 2 I 6 ] 4− . Owing to the coexistence of three luminescent mechanisms-organic cluster luminescence (CL), self-trapped exciton (STE) emission of [Cu 2 I 6 ] 4− , and cluster-centered (CC) state luminescence of [Cu 2 I 4 ] 2− , MPC-W exhibits temperature and excitation wavelength-dependent dynamic luminescence. When the temperature is increased from 77 to 297 K, the luminescence color of MPC-W can be continuously tuned from blue to cyan, green, yellow-green, and white. In the range of 217–463 K, MPC-W displays an abnormal luminescence enhancement phenomenon with increasing temperature. Additionally, upon chemical stimulus, MPC-W can reversibly transform into a blue-light emitting crystal named MPC-B ((C 9 H 20 N 2 O)Cu 2 I 4 ), and a yellow-light emitting crystal named MPC-Y ((C 9 H 18 N 2 O) 7 Cu 8 I 8 ). These unique dynamic luminescent properties endow MPC-W with great application potential in temperature sensing, optical anti-counterfeiting, and password locks. The work provides a new insight for the development of novel wide temperature-responsive multifunctional intelligent luminescent materials.
The alternative text for this image may have been generated using AI.
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DOI
高影响因子
Discover Food
·
2026
·Vol. 6
·期 1
·155
·
IF 3.6
Xiang Nan,Zhao Yihan,Cheng Yaoyao,Guo Xinbo
With the growing global demand for functional foods and the significant food waste from agricultural byproducts, understanding the nutritional potential of underutilized plant tissues is increasingly critical. While mung bean ( Vigna radiata L. Wilczek) is widely cultivated for its seeds’ nutritional value, its mature pods often discarded due to tough texture. This study systematically analyzed polyphenol profiles (total phenolics and 9 specific compounds) and antioxidant capacities in seeds and pods of six mung bean varieties with distinct colors (Zhonglv No.5 (ZL-5), Zhonglv No.13 (ZL-13), Suhuang No.1 (SH-1), LL655, C36, and C158). All varieties exhibited significantly higher total phenolics in pods than seeds, with SH-1 pods and LL655 seeds reaching the highest 4.19 ± 0.83 and 1.71 ± 0.09 mg GAE/g FW among the studied varieties, respectively. Seeds were dominated by vitexin and isovitexin, while pods had abundant caffeic acid. Comprehensive antioxidant evaluation indicated LL655 and C36 with the highest antioxidant potential separately in seed and pod tissues, making them ideal materials for direct functional food applications. Specifically, abundant phenolics hindered the yellowness of mung bean pods, probably owing to their maintenance and completion on other pigments like chlorophyll or carotenoids. Additionally, SH-1 pods contained high total phenolic content, suggesting the utility as a raw material for functional food by-products. These findings provide a scientific basis for the nutritional value of mung bean pods, therefore may improve the utilization of mung bean tissues and promote the value-added applications in functional foods.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Li Wanzhen,Fan Lixiang,Liu Hua,Gui Lin,Zhu Longbao,Song Ping,Zhao Zuchun,Ge Fei,Zhang Weiwei
Diabetic wounds impose a heavy medical burden on patients due to the persistent high blood sugar environment and susceptibility to bacterial infections, especially multidrug-resistant bacteria. To address this critical issue, we designed and synthesized a photothermally active hydrogel. Epigallocatechin gallate (EGCG) was stabilized within a carboxymethyl chitosan (CMCS) and 2-formylphenylboronic acid (2-FPBA) dual-dynamic network via Schiff base and borate ester bonds to form the EGCG—CMCS (EC) hydrogel, while puerarin (PUE) was encapsulated in polydopamine (PDA) nanospheres to enhance its solubility, yielding the PDA-PUE nanospheres. In the 808 nm NIR band, the nanospheres in this composite indicated a high photothermal conversion efficiency (65.7%) and a regular spherical shape with a particle size of approximately 223 nm. In vitro, PDA-PU@EC + NIR inhibited MDR Escherichia coli (MDR E. coli ) and MDR Staphylococcus aureus (MDR S. aureus ) by greater than 98%, as verified by membrane disruption shown by live/dead staining and scanning electron microscopy. In MDR Staphylococcus aureus -infected diabetic mice, it accelerated wound closure (97% by day 11), reduced inflammatory response (as evidenced by significantly decreased fluorescence intensities of IL−6 to 17 ± 2% and TNF- α to 22% of control levels on day 7), and promoted angiogenesis (with marked upregulation of VEGF and CD31 expression), and promoted collagen deposition, outperforming controls. Biosafety tests confirmed low hemolysis (< 5%) and negligible organ toxicity. This work presented a potentially effective strategy to deal with the complex microenvironment of diabetic wound infections, providing a new way of thinking about the effective combination of natural polyphenols, herbal components and photothermal substances.
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高影响因子
Scientific Reports
·
2026
·
IF 4.9
Jia Yongliang,Zhang Dongdong,Lu Hongxing,Li Yanhong,wang Yuehu
Dental caries is a significant global oral health problem, primarily caused by Streptococcus mutans ( S. mutans ). Although previous studies have indicated that Caesalpinia sappan (CS) exhibits anti-caries properties, its specific anti-caries active compounds remain largely unidentified. This study aimed to identify the potential anti-caries components of CS through an integrated strategy involving bioassay-guided isolation targeting S. mutans , UPLC-MS/MS, network pharmacology, molecular docking, and molecular dynamics simulation. Bioassay-guided isolation led to the identification of 33 compounds in fraction 5 from CS , among which brazilin showed the highest content and effectively inhibited biofilm formation and acid production by S. mutans . Network pharmacology analysis predicted 11 active ingredients in CS , including brazilin, targeting 7 potential targets related to dental caries: AKT1, EGFR, BCL2, PTGS2, MMP9, ERBB2, and HSP90AA1, as well as two pathways—nitrogen metabolism and calcium signaling. Molecular docking revealed strong binding affinities of brazilin to PTGS2, EGFR, MMP9, GtfC, GtfD, and GbpC. Further, molecular dynamics simulation revealed strong stability between brazilin and PTGS2, GtfC. Together, these findings not only clarify the anti-caries chemical constituents of CS and their potential mechanisms of action, but also provide new insights into the bioactive components and mechanisms of natural plant-derived medicines for the prevention and treatment of dental caries.
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DOI
PubMed
高影响因子
Scientific Reports
·
2026
·
IF 4.9
Zhou Kun,Yuan Wei,Zhang Fan
Radix Bupleuri-Radix Paeoniae Alba (RB-RPA) has the potential to ameliorate the immune microenvironment in hepatocellular carcinoma (HCC). The interactions between various cells influence the immune microenvironment. However, the effects of the active components (saikosaponin D (SSD) and paeoniflorin) of RB-RPA on HCC and the cell interactions within its microenvironment warrant further investigations. We established orthotopic mouse models of HCC using Hepa 1–6 cells (a hepatoma cell line) to investigate the infiltration of cancer-associated fibroblasts (CAFs). Following this, we knocked down CLCF1 in the CAFs to explore their interactions with Hepa 1–6 cells. We subsequently treated CAFs with SSD-paeoniflorin. In T-cell activation assays, we overexpressed PD-L1 in Hepa 1–6 cells and co-cultured these cells with T cells. Additionally, we treated HCC mice with SSD-paeoniflorin and induced the overexpression of CLCF1 in vivo. In mice with HCC, tumors were characterized by substantial infiltration of CAFs, which displayed elevated levels of the protein CLCF1. These CAFs play a role in suppressing the HCC immune microenvironment and elevating PD-L1 levels through the production of CLCF1. At the cellular level, SSD-paeoniflorin inhibited the growth of CAFs and the expression of CLCF1 and also suppressed the PD-L1 level in Hepa 1–6 cells through CAF-derived CLCF1. Mechanistically, CLCF1 may promote PD-L1 expression via the JAK/STAT3 signaling pathway. Furthermore, the overexpression of PD-L1 in Hepa 1–6 cells suppressed T cell proliferation and activation. In animal studies, SSD-paeoniflorin improved the HCC immune microenvironment by enhancing the interaction between CAFs and Hepa 1–6 cells through CLCF1. Collectively, SSD-paeoniflorin inhibits CLCF1 secretion in CAFs to downregulate PD-L1 expression in Hepa 1–6 cells and may reactivate the anti-tumor immune microenvironment in HCC.
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PubMed
高影响因子
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